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CHEK2*1100delC is not an important high-risk gene in families with hereditary prostate cancer in southern Sweden

Objective. CHEK2* 1100delC is a frame-shifting germ-line mutation which abolishes the function of cell-cycle-checkpoint kinase 2 (chk2) and hence impairs the cells' response to DNA damage. This variant occurs in approximate to 1% of the general Western population but has been reported to be more common among patients with breast and prostate cancer. The aim of this study was to investigate the sig

Modelling regional climate change effects on potential natural ecosystems in Sweden

This study aims to demonstrate the potential of a process-based regional ecosystem model, LPJ-GUESS, driven by climate scenarios generated by a regional climate model system (RCM) to generate predictions useful for assessing effects of climatic and CO2 change on the key ecosystem services of carbon uptake and storage. Scenarios compatible with the A2 and B2 greenhouse gas emission scenarios of the

In vitro fertilization (IVF) in Sweden: Risk for congenital malformations after different IVF methods.

BACKGROUND: The possible excess of congenital malformations in infants born after in vitro fertilization (IVF) has been much discussed in the literature, with controversial conclusions. This population based study is aimed at analyzing the presence of congenital malformations in a large group of infants born after IVF and to compare malformation risk both with that of all infants born and accordin