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BACKGROUND: Conditions exhibiting features of two different autoimmune liver diseases are designated overlap syndromes. Variant forms display some, but not all, characteristics of a distinct autoimmune liver disease. We describe transitions over time between variant forms of PBC, i.e. AMA-negative PBC, autoimmune hepatitis (AIH)-PBC overlap and autoimmune cholangitis (AIC) in a large cohort of PBC

Population-based cancer registries are widely used to provide key information about cancer incidence, survival, determinants of progression and clues about pathogenesis. To substantially expand the limited data on diagnostic accuracy and completeness for lym-phoproliferative (LP) tumors in such databases, we conducted a retrospective investigation of close to 1,000 cases diagnosed during 4 decades

BACKGROUND: Polyglutamine (polyQ) diseases are characterised by the expansion of CAG triplet repeats in specific genes. The accumulated encoded proteins affect the transcription of numerous transcription factors. We investigated whether polyQ diseases reduce the risk of cancer development. METHODS: Data on patients with the polyQ diseases Huntington's disease (HD), spinobulbar muscular atrophy (

This study raises the question of how marriage market relevant status characteristics are distributed among partners in exogamous relationships. The status exchange hypothesis posits that partners in racially and ethnically heterogamous relationships trade status characteristics, mainly education. We address this hypothesis focusing on intermarriages between immigrants and native men (N=606,257) a

During 2015 the struggles of people who searched to enter and move across Europe became increasingly intense with unthinkable numbers of deaths on the sea and other dangerous parts of the various alternative routes to and across Europe. Initially Europe witnessed a popular mobilisation of solidarity and demands for a humane response articulated through government officials as well as in the media.

Butterfly monitoring schemes are recording programs initiated to monitor nationwide butterfly abundance and distribution patterns, often with help from volunteers. The method generates high-resolution data, but may be associated with a degree of habitat sampling bias if volunteers prefer to survey areas perceived to be high-quality butterfly habitats. This can result in habitats becoming underrepr

Palaeomagnetic studies of continuous geological archives and archaeological artefacts are required to reconstruct geomagnetic field changes beyond the range of historical observations. In this thesis I assess the reliability of sedimentary palaeomagnetic data and Holocene dipole field reconstructions. New palaeomagnetic records are presented from a maar crater lake in New Zealand and a post-glacia

Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. T2D research has in recent years invested tremendous efforts in identifying new risk variants for the disease. It has proven t

Background: Physical inactivity presents a major public health challenge and is estimated to cause six to ten percent of the major non-communicable diseases. Studies show that immigrants, especially women, have an increased risk of non-communicable diseases compared to ethnic Swedes. Somali immigrant women have increased rates of overweight and obesity, low fitness levels and low levels of cardior

Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). The aim of this thesis has been to investigate functional and genetic events that

Effekterna av den globala uppvärmningen har visat sig på alla kontinenter och i Sverige har det blivit både varmare och blötare. Risker som kopplas till klimatförändringar i Sverige är torka, värmevågor och översvämningar och dessa risker måste hanteras på alla samhällsnivåer av flera olika aktörer. Stöd och råd för hur samhällsaktörer kan förbereda sig kommer från både Nationellt kunskapscenter f

Issue of the study: Corporate social responsibility (CSR) is becoming a normal part of every corporate’s business. Companies are putting a lot of effort on sustainability and social responsibility due to an increase in regulations and demands from different stakeholders. Though there exists a gap between how much effort the companies put on CSR and how consumers perceive these efforts. Some compan