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The aim of this thesis was to evaluate the role of interatrial conduction defects in the genesis of lone paroxysmal atrial fibrillation (AF) using combined approach of non-invasive signal-averaged P-wave ECG, invasive electrophysiological (EP) studies, anatomical studies and animal experiments. Non-filtered signal-averaged P-wave ECG revealed irregularities in orthogonal P-wave morphology and the
Coagulation factor IX (FIX) is a vitamin K-dependent serine protease zymogen that circulates in plasma. Defects in FIX cause the bleeding disorder hemophilia B. FIX contains a Gla module, two Epidermal Growth Factor (EGF) -like modules and a serine protease region. In this thesis, studies have been performed on the N-terminal EGF module, which binds one Ca2+. — The present results show that bindin
A broad, distinctive material presentation is done, which is linked to some variables of psychological value, stating a research for the authenticity of Garborg in viewing him as well a symptom bearer as a symptom solver. An introduction to Garborg is meant to be an invitation, especially to those who are not so well acquainted with him as a person and a writer. Out from a period of about 110 year
This thesis summarizes work in which time-resolved X-ray diffraction has been used to probe crystalline materials, thereby revealing the dynamics of phonons and phase transitions. X-ray diffraction is the standard tool in investigations of structure on the atomic scale. It has been used for a long time, and has successfully helped scientists to find the structure of a wide range of materials. The
In this work, mathematical models have been developed describing drug release from film-coated reservoir systems as well as drug release and polymer dissolution from swelling and dissolving polymer tablets. The model derivation of both systems is based on a mechanistic approach. The model describing drug release from reservoir systems, i.e. from single, film-coated pellets, was validated against e
This dissertation examines the correspondence of the 18th-century German authors Anna Louisa Karsch and Johann Wilhelm Ludwig Gleim. The main emphasis of the present study is to demonstrate how readings of Karsch's and Gleim's correspondence shed light on epistolary culture. Particular attention is paid to the notion of epistolary culture as a relatively unrestrained ?experimental setting? for bou
Many anthropogenically-produced or beneficiated materials contained in “end-of-life” products retain a great proportion of the invested manufacturing work when discarded. Very few such materials are reconstituted and applied in new products at the same material inherent quality level as in their first lifetime – a process known as “closed-loop recycling”. In general, industrial society maintains a
The present study deals with different aspects of the mitsvat mezuzah in Rabbinic literature from the first to the sixteenth centuries, with some emphasis on the medieval sources. Through a charting of statements regarding the mezuzah as an object, and the mitsvat mezuzah and its fulfilment, an overview is given of the development of the mezuzah and the perception of it
In software engineering, the quality of software and in particular the software reliability has to be controlled and improved. Hence there is a need for measuring and controlling the number and appearance of software faults and failures. This thesis presents models for estimation of residual faults after inspections and a model for usage specifications which enables estimation of operational failu
One part of the objective is to analyze how different ventilation systems perform in practice when it comes to supplying and exhausting designed air flow in different outdoor and indoor conditions. The other part is to analyze the design criterias and the energy use of a variable air volume system based on controlled static pressure at the branch duct level and supplying outdoor air only. To inves
The topic of the thesis is control of Homogeneous Charge Compression Ignition (HCCI) engine dynamics. HCCI offers a potential to combine high efficiency with very low emissions. In order to fulfill the potential benefits, closed-loop control is needed. The thesis discusses sensors, feedback signals and actuators for closed-loop control of the HCCI combustion. Closed-loop control of the HCCI combu
Enterprise Systems are one of the most important developments in corporate information systems during the last decade. These integrated information systems are characterized by a number of features which include a very broad scope and functionality, as well as being generic, master data, and business-process orientated. Together, these features make Enterprise Systems unique vis-à-vis other inform
Sleep disordered breathing (SDB) including obstructive and central sleep apnoea/ hypopnoea as well as periodic breathing (PB) is common and is believed to increase risk for mortality in patients with congestive heart failure (CHF). Mandibular advancement device (MAD) has widely been recommended for treatment of obstructive sleep apnoea but the method has never been investigated for treatment of SD
Scandinavian Cardiovascular Journal, 2011, 45(S58), 35.
