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Nontypeable Haemophilus influenzae (NTHi) is a remarkably proficient colonizer of the human respiratory tract. The aim of this thesis has been to characterize currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to host tissue and evasion of the host innate immunity. We have shown that the NTHi virulence factor Pr
Outer membrane vesicles (OMV) have the size of nanoparticles and are released from the outer membrane of most Gram-negative bacteria. The OMV reflect the composition of the bacterial outer membrane, including lipids and virulence factors specific for the pathogen, and are involved in pathogenesis and bacterial survival. Moraxella catarrhalis and Haemophilus influenzae are Gram-negative bacterial s
One of the major determinants of the final infarct size during an acute coronary occlusion is the size of the myocardium subjected to ischemia. Identification and quantification of this so-called myocardium at risk in the acute phase of ischemia has been difficult in patients with conventional methods, such as myocardial perfusion single-photon emission computed tomography (SPECT) or electrocardio
Background: Gender differences in palliative care is an under-researched area, both internationally and in Sweden. A regional pilot study by our research group indicated that men have greater unmet palliative care needs prior to referral. Building on these findings, the aim of this study was to examine gender differences in the quality of care received at the end of life within specialized palliat
The role of market-specific factors in driving business model adaptation during international expansion has received limited scholarly attention, particularly among early-stage start-ups in the agricultural biotechnology industry. Therefore, this study asks how market-specific factors influence business model adaptation during internationalization in the agricultural biotechnology sector, thereby
This thesis examines how principles associated with direct democracy are transformed when citizen participation is organised through digital platforms. It compares Riketsröst, an early-stage voting initiative intended for local use in Vellinge, with Malmöinitiativet, an institutionalised municipal e-petition system. The purpose is to analyse how the two cases enable agenda-setting, communication a
It is sometimes said that modern politics has lost track of ideology and vision - that personal charisma and expertise is rewarded more than firm beliefs and connections with an organised movement. In their book Technopopulism: the New Logic of Democratic Politics, Christopher J. Bickerton and Carlo Invernizzi Accetti go beyond such suspicions. Their main argument is that the organisational politi
Abdominal aortic aneurysm (AAA) develops in 3-6% of the population over 65 years and affects mainly men. AAA has a complex etiology involving inflammation, proteolysis, fibrinolysis and coagulation. The general aim of the present thesis was to study the associations between markers of inflammation, proteolysis, fibrinolysis and coagulation with aneurysm size and growth. In paper I associations bet
The underlying question in localization is, where am I? In this thesis a purely image based approach is proposed to solve this problem. In order to create a complete image based system, there are many subproblems that have to be addressed. The localization problem can also be solved in other ways, for example, with a GPS. Two advantages with using images compared to GPS are that no open sky is nee
This thesis describes a number of coherent processes, such as quantum information processing, superradiance and electromagnetically induced transparency, which have been experimentally implemented using rare-earth-ion-doped crystals. The rare-earths are a class of elements that have in common, an atomic structure that allows for very long lifetimes as well as coherence times, both on optical trans
Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. The specificity of the vector is however important to avoid potential off-target effects
Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xen
bstract The real estate sector in Sweden has long been characterized by high entry barriers, strict regulations, and a high demand for large initial capital. These factors make it challenging for new ventures to succeed in the market. With this background, it seems relevant to understand which driving factors can be related to entrepreneurial success. This study researches how specific characteris
Contributor to climate change, cities are the major responsible for a great amount of natural resource consumption and global waste production as a consequence of the ”take, make, dispose" aspects of our linear economic model. In face of this issue, Circular Economy (CE) is a new concept that seeks to decouple economic growth from the consumption of finite resources by shifting the linear eco
Title: Underprissättning på den svenska marknaden - går den att förutspå? Seminar date: 2019-06-04 Course: FEKH89, Bachelor Degree Project in Financial Management, 15 ECTS Authors: Ebba Halvarsson, Erika Langåker och Sigrid Jonsson Advisor: Maria Gårdängen Keywords: Underpricing, Initial public offering, Ex ante, Nasdaq Stockholm, Nasdaq First North, Multiple regression, Asymmetric information Pur
Heart failure is a clinical syndrome characterized by an inability of the heart to meet the metabolic demands of the body. Approximately 1-2% of the population in the western society has the diagnosis, and the 5-year mortality rate is comparable with the common cancer diagnoses. The lack of reliable objective measures of heart failure motivates research in this direction. Blood flow is an essentia
