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BACKGROUND: Protein S is an important regulatory protein of the coagulation cascade. The risk for venous thrombosis associated with protein S deficiency has been uncertain because all previous risk estimates used phenotypic evaluation alone, which can be ambiguous.OBJECTIVE: To quantitate the risk for thrombosis associated with a characterized protein S gene mutation that causes a Gly295-->Val sub
Föreskrifter för utbildningen pÃ¥ forskarnivÃ¥ vid Samhällsvetenskapliga fakulteten FÖRSÄTTSSIDA STYRDOKUMENT Riktlinjer för utbildning på forskarnivå vid Samhällsvetenskapliga fakulteten Typ av styrdokument: Riktlinjer Definition av typen av styrdokument: Enligt universitetets riktlinjer för styrdokument (STYR 2024/1601) fastställer riktlinjer hur någon ska eller bör handla inom det område rik
Popular Abstract in Swedish Datorgrafik handlar om att övertyga betraktaren. En huvuduppgift är att generera verklighetstrogna bilder utifrån tredimensionella modeller. Med hjälp av datorer simuleras hur dessa modeller interagerar med ljus. Betraktaren skall helst inte reflektera över om bilden han ser är ett fotografi eller en helt och hållet genererad bild. I denna avhandling presenteras algoritModern graphics hardware pipelines create photorealistic images with high geometric complexity in real time. The quality is constantly improving and advanced techniques from feature film visual effects, such as high dynamic range images and support for higher-order surface primitives, have recently been adopted. Visual effect techniques have large computational costs and significant memory bandwid
Popular Abstract in Swedish Inom sjukvården används strålning för att behandla cancer. Vid strålbehandling är det viktigt att man i förväg vet precis hur strålningen ska ges till patienten för att resultatet av behandlingen skall bli bra. Ett hjälpmedel som används för detta är ett datorprogram (dosplaneringssystem) som, med utgångspunkt från patientens anatomi, beräknar hur varje enskild patient Gel dosimetry is a new dosimetry method applied in radiation therapy. Gel dosimeters consist of a radiation sensitive gel, which can integrate absorbed doses from several radiation sources or beams. The dose to the gel can be evaluated by magnetic resonance imaging (MRI), a procedure that is the focus of the present thesis. A robust tool for the evaluation of the nonuniformity in MRI has been dev
AbstractThe overall aims of this thesis were to use echocardiography to non-invasively, delineate early structural andfunctional changes following orthotopic heart transplantation (OHT), and to define reference values in the contextof gender and bridging with mechanical circulatory support.Several factors might affect myocardial function in OHT patients rendering the use of normal values fortranst
Uppsatsen behandlar i huvudsak tre mer eller mindre avgränsade problem med anknytning till återbäringsinstitutet i 17 kap ABL. Ett grundläggande problem med regleringen av värdeöverföringar är att de ofta upptäcks långt efter att de genomfördes, vilket ger upphov till en viss typ av problem. Den första problemställningen som behandlas rör värderingsfrågor. De frågetecken som finns i denna del rörThis paper essentially describes three more or less defined issues related to the institution “Value transfers” in Section 17 in the Swedish Companies Act (2005:551). An underlying problem with the regulation of value transfers is that a value transfer often is revealed much later than the transaction took place, which causes a certain type of problems. The first issue described concerns valuatio
Plasmodium berghei is the causative agent of rodent malaria and is widely used as a model system to study the liver stage of Plasmodium parasites. The entry of P. berghei sporozoites into hepatocytes has extensively been studied, but little is known about parasite-host interaction during later developmental stages of the intracellular parasite. Growth of the parasite far beyond the normal size of
Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of monoclonal CD5+ B cells with low surface immunoglobulins (IG). About 40% of CLL clones utilize quasi-identical B cell receptors, defined as stereotyped BCR. CLL-like stereotyped-IG rearrangements are present in normal B cells as a part of the public IG repertoire. In this study, we collected details on the representation an
To resist infections, robust defense mechanisms of the airways are essential. Retinoic acid promotes differentiation and maintains the phenotypic characteristics of bronchial epithelium. In addition, it induces the expression of the antibacterial growth factor midkine (MK). In the present study, we explored the expression and antibacterial activity of MK in an airway context. MK was detected in br
Zircon crystals from a locally charnockitized Paleoproterozoic high-K metagranite from the Kerala Khondalite Belt (KKB) of southern India have been investigated by high-spatial resolution secondary ion mass spectrometry analysis of U-Th-Pb and rare earth elements (RE), together with scanning ion imaging and scanning ion tomography (depth-profiled ion imaging). The spot analyses constrain the magma
During development, information about the three-dimensional shape and mechanical properties of the body is laid down in the synaptic connectivity of sensorimotor systems through adaptive mechanisms. This functional adaptation occurs through alteration of connection properties. Here, we characterize the differences between strong and weak connections in the nociceptive withdrawal reflex in adult de
The brain lesions in spontaneously hypertensive stroke-prone rats (SHRSP) are characterised by multifocal microvascular damage, breakdown of the blood-brain barrier, massive extravasation of plasma constituents and severe brain oedema, with consequent spongy and cystic tissue destruction in the cerebral cortex and basal ganglia as well as loosening of the white matter. In this paper we analyse in
A dolerite sill cutting slightly older basalt in west-central Sweden shows a strong chemical variation (54%
Prominent features of HD neuropathology are the intranuclear and cytoplasmic inclusions of huntingtin and striatal and cortical neuronal cell death. Recently, synaptic defects have been reported on HD-related studies, including impairment of neurotransmitter release and alterations of synaptic components. However, the definite characteristics of synapse dysfunction and the underlying mechanisms re
Objectives: The overall aim of the Swedish Breast Reconstruction Outcome Study was to investigate national long-term outcomes after mastectomy with or without breast reconstruction. The current report evaluates breast reconstruction (BR) patterns in Sweden over time. Materials and methods: This is a cross-sectional, registry-based study where all women operated with mastectomy 2000, 2005, 2010 wer
Background: Early trials have reported a beneficial effect from tamoxifen treatment in patients with unresectable pancreatic cancer, in particular in women. However, the presence and prognostic significance of female hormone receptors in pancreatic or other periampullary cancers has not yet been described. Methods: Immunohistochemical screening of normal and malignant pancreatic tissue revealed t
In modern gas turbine engines, the first stage vane endwall endures high thermal load with the increase of the turbine inlet temperature and the uniformity of the temperature distribution at combustor outlet. Moreover, the endwall secondary flow forces the coolant flow toward the suction side, resulting in hot regions along the pressure side endwall. In the worst case, hot regions lead to thermal
The possibility that nitric oxide synthase (NOS) inhibitors influence dynorphin immunoreactivity following hyperthermia was examined in a rat model using a pharmacological approach. Previous reports from our laboratory show that hyperthermia induces an upregulation of NOS in several brain regions that seems to be instrumental in causing cell injury. Recent reports suggest that nitric oxide (NO) ca
