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Myeloid leukemia of Down syndrome has a better prognosis than sporadic pediatric acute myeloid leukemia. Most cases of myeloid leukemia of Down syndrome are characterized by additional cytogenetic changes besides the constitutional trisomy 21, but their potential prognostic impact is not known. We, therefore, conducted an international retrospective study of clinical characteristics, cytogenetics,

Within innate immune signaling pathways, Interleukin-1 receptor (IL-1R&)-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors (TLR) and the IL-1R. Whereas human IRAK4-deficiency was shown to lead to severe immunodeficiency in response to pyogenic bacterial infection during childhood, little is known about the role of human IRAK2. We here identified a non-syno

In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of ALK mutations in neuroblastoma clonal evolution.

Background: Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression is crucial for evaluating the long-term benefits of disease-modifying treatments. We examined associations among changes in Alzheimer’s disease (AD) stages and outcomes that are important to patients and their care partners including activities of daily livin

We present new data for the ∼3.0 Ga Maniitsoq Norite Belt of the Akia Terrane, West Greenland, with the aim of understanding its petrogenesis. The Maniitsoq Norite Belt is hosted in regional tonalite-trondhjemite-granodiorite (TTG) and dioritic orthogneisses, intruded by later sheets of TTG and granite pegmatites, and comprises two main rock types: plagioclase-rich “norites” and pyroxene-rich “mel

Background: The prevalence of autism in Denmark has been increasing, reaching 1.65% among 10-year-old children, and similar trends are seen elsewhere. Although there are several factors associated with autism, including genetic, environmental, and prenatal factors, the molecular etiology of autism is largely unknown. Here, we use untargeted metabolomics to characterize the neonatal metabolome from

The study of brain development in humans is limited by the lack of tissue samples and suitable in vitro models. Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device. The approach, named microfluidic-controlled stem cell regionalization (MiSTR), exposes pluripotent stem cells to signaling gradients that mimic developmental patterning.

Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, while PAK4 gene depletion delays MMTV-PyMT driven tumors. Importantly, PAK4 prevents senescence-like gr

Radiolabeled targeting agents have emerged as valuable tools for the treatment of disseminated cancer. Monoclonal antibodies (mAbs) are widely employed as carriers for diagnostic and therapeutic radionuclides due to their exceptional specificity and affinity. However, their prolonged circulatory half-life can diminish diagnostic efficacy and increase radiation exposure to non-target tissues in the

Heat stress events will be more frequent and intense in the future. These events will challenge the capacity of organisms to exhibit sufficient metabolic flexibility to adapt to such variations. To better understand the acclimation processes implemented in response to acute warming, with an integrative approach we examined in vivo metabolic rate and cardiac mitochondrial respiration in the Rhône s

This paper reports and demonstrates a packetponder for access/metro node consolidation and aggregation using common-form-factor pluggables (CFFP), which can simplify edge network architectures.

Språk- och litteraturcentrum Författarskolan Kurslitteratur för FSPA01 Skrivandets pedagogik: praktiska och teoretiska förhållningssätt, 3 hp, ht 2025 (Fastställd i Sektionsstyrelse 2, SOL-Centrum, 2 juni 2025) Hoel, Torlaug Løkensgard (2001), Skriva och samtala: lärande genom responsgrupper, Lund: Studentlitteratur (278 s.) Nyberg, Fredrik (2016), Den mjuka texten, Göteborg: Göteborgs universite

https://www.sol.lu.se/media/utbildning/dokument/kurser/FSPA01/20252/Litteratur_FSPA01_HT25_1.pdf - 2025-11-20

In July 2024, the Swedish government submitted the report ”An Appropriate Protection of Society – Some Reforms to Criminal Law and Penal Enforcement Legislation" (Ett ändamålsenligt samhällsskydd – Vissa reformer av straff- och straffverkställighetslagstiftningen, SOU 2024:48). The aim of the government inquiry was to strengthen public safety, increase protection for the victim of crime, and

Detta projektet har gjorts tillsammans med Staffanstorps kommun med syfte att ta fram en svensk och säsongsanpassad salladsbuffé till alla kommunens skolor från förskoleklass till klass 9. I kommunens kostpolicy står det att de strävar efter att ha en hög andel av säsongsanpassade livsmedel och ökad andel lokalt producerade livsmedel. I detta arbete har det tagits fram underlag till en svensk och

Sexualitet har länge varit föremål för kontroll, kategorisering och reglering. I vårt nutida västerländska samhälle har vi lagar som reglerar vilka sexuella handlingar som är acceptabla och vilka som inte är det, och vissa typer av sexualitet är även sjukdomsklassade. De senaste åren har viss form av sex diskuterats intensivt i svenska nyhetsmedier; nämligen pornografi. Diskussionen berör frågor oThe aim of the study is to examine discourse on pornography in Swedish news media. The methodological point of departure is Critical Discourse Analysis, as presented by Fairclough. The empirical material consists of 69 articles, editorials and chronicles publicized in Swedish news media between July 2013 and March 2017. The primary theoretical point of departure of the study is Fairclough’s critic

Title: Inbound Marketing – A strategy for success? A qualitative study based on high involvement products from the perspective of consumers and Mercedes-Benz Seminar date: 2018-06-01 Course: FEKH29 Business Administration: Bachelor Degree Project in Marketing Undergraduate Level Author: Alice Beckman, Clara Michélsen, Julia Torstensson Advisor: Clara Gustafsson Key words: Inbound Marketing, The b

Vad spelar Arktis för roll i klimatförändringarna? Denna avlägsna, och glest befolkade, del av världen utgör faktiskt en viktig del av klimatsystemet. Arktis spelar en betydande roll i kolets kretslopp; vilket innefattar såväl koldioxid och metan, två av de viktigaste växthusgaserna. Förändringar i koncentrationer av växthusgaser påverkar hur mycket värme som hålls kvar i jordens atmosfär. VåtmarkMethane is one of the most important greenhouse gases, and the Arctic region plays an important role in its dynamics. Due to limited observations in this remote and often harsh environments, large uncertainties surround the role of the Arctic region in a warming climate. In this thesis, I examine the performance of the three low-cost solid state sensors, Figaro sensors TGS2600-B00, TGS2611-C00 an

Uppsatsens syfte är att undersöka hur och varför lagstiftningen kring påföljden livstidsstraff vid mord har förändrats under de senaste 15 åren, 1999-2014, i Sverige samt de bakomliggande tankegångarna. Uppsatsen presenteras ur ett rättshistoriskt perspektiv. För att kunna ge en bättre bakgrund har en kort historisk bakgrund presenterats som sedan övergår i uppsatsens avhandling gällande de senaThe purpose of this essay is to investigate how and why the legislation concerning the sentence of life imprisonment for murder has changed in Sweden over the past 15 years, 1999-2014, and the thought process behind the changes. The investigation will be presented from a legal historical perspective. In order to explain the development a short historical background has presented the thoughts behi

Ett väl fungerande skattesystem utgör basen för finansieringen av välfärdssystemet. Skatteflykt ger upphov till skattebaserosion, ett fenomen som ger upphov till stora kostnader, såväl för Sverige som för andra stater och försvårar finansieringen av välfärdssystemet. Generalklausuler utgör ett verktyg mot skatteflykt. I Sverige finns sedan många år tillbaka en generalklausul mot skatteflykt i skatThe basis for the funding of welfare systems is a well-functioning tax system. Tax base erosion, founded in tax avoidance, imposes significant costs for both Sweden and other countries and it risks obstructing the funding of the welfare system. General Anti-Avoidance Rules (GAARs) is an instrument for countering tax avoidance. For many years, Sweden has had a GAAR in the Swedish Anti-Avoidance Act

The 1st of July 2018, a new legislation regarding rape came into force, based on consent and voluntary participation. Considerations regarding a consent-based legislation has been ongoing and disputed, not least during the last century and twice before the question has been investigated in the 1998 sex crime committee and the 2008 sex crime investigation. Since the change it is no longer required