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Atmospheric aerosol particles have substantial influence on climate and air quality. However, the anthropogenic influence on the atmospheric aerosol is still poorly known. This limits the understanding of past and future climate changes. Additionally, both epidemiological and toxicological studies indicate adverse health effects of inhaled aerosol particles. In order to study the effect of atmosph
Popular Abstract in Swedish Forskning kring biomarkörer har revolutionerat cancersjukvården. Några av de mest kända exemplen är PSA-testet som kan användas för att identifiera patienter med ökad risk för prostata cancer eller de nya antikroppsbehandlingarna, t.ex mot HER2 (trastuzumab/Hercepin) eller CD20 (rituximab/Rituxan), som gör att man nu ofta kan förlänga eller bota patienter som tidigare hThe goal of biomarker discovery is to identify disease defining molecules, which could be used to improve early detection and/or to predict survival and response to treatment. This thesis is about the transcription factor SOX11, a protein discovered in the context of mantle cell lymphoma in 2008, which shows great potential to be used as a clinical relevant biomarker. The aim of this thesis is to
Abstract in UndeterminedSubject-specific finite element models have been used to predict stress-state and fracture risk in individual patients. While many studies analysed quasi-axial loading configurations, only few works simulated sideways load configurations, such as those arising in a fall. The majority among these latter directly predicted bone strength, without assessing elastic strain predi
The membrane is often considered as the heart of the proton exchange membrane fuel cell (PEMFC), and it is of pivotal importance for the involved transport phenomena and performance of the entire PEMFC. The Nafion(R) membrane is the most commonly used type of membrane in PEMFCs. In this paper, the nano-scale structure of the Nafion(R) membrane is reconstructed using dissipative particle dynamics.
In the present work, fiber-based frequency-modulated light scattering interferometry (FMLSI) is developed and employed for studies of optical properties and dynamics in liquid phantoms made from Intralipid(®). The fiber-based FMLSI system retrieves the optical properties by examining the intensity fluctuations through the turbid medium in a heterodyne detection scheme using a continuous-wave frequ
Apolipoprotein M (ApoM) is a 25-kDa HDL-associated apolipoprotein and a member of the lipocalin family of proteins. Mature apoM retains its signal peptide, which serves as a lipid anchor attaching apoM to the lipoproteins, thereby keeping it in the circulation. Studies in mice have suggested apoM to be antiatherogenic, but its physiological function is yet unknown. We have now determined the 1.95
In order to allow different software applications, in constant evolution, to interact and exchange data, flexible file formats are needed. A file format specification for different types of content has been elaborated to allow communication of data for the software developed within the European Network of Excellence "NANOQUANTA", focusing on first-principles calculations of materials and nanosyste
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by tremor, muscle rigidity and bradykinesia, which is primarily due to the degeneration of nigrostriatal dopaminergic neurons. Currently, patients are primarily treated with L-dopa and other drugs that enhance dopaminergic function. Those are effective during the first years, but eventually the majority of patients
Lipid membrane and lipopolysaccharide (LPS) interactions were investigated for a series of amphiphilic and cationic peptides derived from human heparin cofactor II (HCII), using dual polarization interferometry, ellipsometry, circular dichroism (CD), cryoTEM, and z-potential measurements. Antimicrobial effects of these peptides were compared to their ability to disorder bacterial lipid membranes,
The immobilization of functional biomolecules to surfaces is a critical process for the development of biosensors for disease diagnostics. In this work we report the patterned attachment of single chain fragment variable (scFv) antibodies to the surface of metal oxides by the photodeprotection of self-assembled monolayers, using near-UV light. The photodeprotection step alters the functionality at
We have studied the geometry and singlet-triplet energy difference of two mono-nuclear Ni2+ models related to the active site in [NiFe] hydrogenase. Multiconfigurational second-order perturbation theory based on a complete active-space wavefunction with an active space of 12 electrons in 12 orbitals, CASPT2(12,12), reproduces experimental bond lengths to within 1 pm. Calculated singlet-triplet ene
Background: Conventional radiography is insufficient for diagnosis in a small but not unimportant number of hip fractures, and secondary imaging with computed tomography (CT) or magnetic resonance imaging (MRI) is warranted. There are no convincing observer variation studies performed for conventional radiography or CT in occult fractures, and no large materials for MRI. Purpose: To assess observe
Dose conversion coefficients relating the kerma free-in-air to effective dose have been studied. In order to do so a sampling scheme encompassing all the risk organs and tissues was developed for the Alderson RANDO phantom. Preliminary results are shown for some specific organs irradiated with a point source in the laboratory.
