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The glomerular structure of the primary olfactory neuropil has long been thought to play an important role in odour coding. In insects, the number of glomeruli in the antennal lobe is limited in most species to fewer than 100 compared with more than 1,000 in vertebrates, making it possible to identify individual glomeruli. A complete three-dimensional atlas of the glomeruli within the antennal lob

We have recently shown that 17β-estradiol (E2) and the synthetic G protein-coupled receptor 30 (GPR30) ligand G-1 have antiapoptotic actions in mouse pancreatic islets, raising the prospect that they might exert beneficial effects also in human islets. The objective of the present study was to identify the expression of GPR30 in human islets and clarify the role of GPR30 in islet hormone secretion

Background: Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium. Syndecan 3 seems to prevail in the human uterus among heparan sulphate proteoglycans, showing the most significant increase during labour. The aims of the present study were to investigate syndecan 3 and connexin 43

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in many different organ systems, activation of leukocytes and production of pro-inflammatory cytokines. The heterodimer of the cytosolic calcium-binding proteins S100A8 and S100A9 (S100A8/A9) is secreted by activated polymorphonuclear neutrophils (PMNs) and monocytes and serves as a seru

Convincing data has suggested that four and a half LIM domain 2 protein (FHL2) serves a key function in cancer cell metastasis and that microRNA (miR)-340-5p can regulate cancer cell migration. The current study hypothesized that targeting FHL2 expression by miR-340-5p in colon cancer may attenuate colon cancer cell migration and invasion. FHL2 expression was therefore assessed in colon cancer mic

The morphological structure of the nervous system is ultimately the basis of its function. Analyses of the anatomical layout of brain areas, single neuron morphologies, and the synaptic connectivity of neurons are therefore essential for a comprehensive understanding of the computational processes implemented in neuronal networks. Insect brains have long served as models to examine neuronal circui

Objective: Constant exposure of pancreatic islets to high levels of glucose or free fatty acids can lead to irreversible beta-cell dysfunction, a process referred to as glucotoxicity or lipotoxicity, respectively. In this context a role for nitric oxide generated by pancreatic islet has been suggested. The present investigation examined whether the route of glucose administration, i.e., given oral

The quality of powder is determined by its functionality such as dissolution, encapsulation and flowability. The functionality of powder is in turn determined by their primary properties such as morphology and composition which need to be studied. Hence morphology and surface composition has been largely investigated in spray dried powders and individually dried particles. On the contrary, there i

Popular Abstract in Swedish Glatt muskulatur är nödvändig för funktionen hos de flesta inre organ såsom blodkärl, tarmar, gallblåsa, livmoder, urin och luftvägar. I artärer bildar glatta muskelceller ett cirkulärt lager, som skiljs från blodet genom ett tunt endotelcellslager. Muskelns främsta uppgift är att kontrollera blodkärlens diameter, och därmed blodflödet till de vävnader som de försörjer.Intracellular Ca²⁺ is a key regulator of vascular contractility, and thereby of blood perfusion and pressure. Ca²⁺ signals are essential also for cell migration, proliferation and regulation of numerous enzymes. Besides producing vascular contraction smooth muscle cells may also modulate to a synthetic phenotype and proliferate as an initial stage in the atherosclerotic proce

α-Synuclein is an intrinsically disordered protein implied in still not-well-known healthy function and also found as the main component of aggregates in Lewy bodies and Lewy neurites, hallmarks of the Parkinson’s disease. In both of cases, the interaction with lipid membranes is crucial. In this study we propose the investigation of the interaction between α-Synuclein and model systems made of DO