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Popular Abstract in Swedish Regleringen av esofagus och den nedre esofagussfinkterns motilitet har rönt intresse på grund av dess betydelse vid vissa sjukdoms-tillstånd såsom gastroesofageal reflux och akalasi. Den nedre esofagussfinktern har vidare använts som modell för farmakologiska och fysiologiska studier av viss typ av autonom neurotransmission, s k icke-adrenerg, icke-kolinerg (NANC) neuroThe inhibitory neuromuscular control of the human and cat lower oesophagus was investigated by morphological, functional, and biochemical methods. A supply of nerve fibres and myenteric cell bodies, containing nitric oxide synthase (NOS), haem oxygenase (HO)-2, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase activating peptide (PACAP) was observed. The highest density of nerve

Popular Abstract in Swedish De senaste årens framsteg inom bioteknologin har medfört att det utvecklas allt fler proteinbaserade läkemedel. Detta innebär att vi har fått bättre mediciner mot allvarliga sjukdomar, men tyvärr måste proteiner nästan alltid tas med spruta, och ofta krävs långa behandlingar med dagliga injektioner. Det finns även andra grupper av läkemedelssubstanser som ökar i omfattnControlled-release formulations reduce the frequency of injections and better maintain plasma concentrations within the therapeutic window. Poly(D,L-lactide-co-glycolide) (PLG) is currently the most frequently used biodegradable polymer for this application. In order to be able to control the release rate, it is vital to know the underlying release mechanisms. A novel method for measuring the diff

Perovskite research has quickly gone from non-existent to one of the biggest reseach areas in Photo- voltaics. There are still many questions to be solved regarding the stability, environmental impact, reproducible large area devices, efficiency and module fabrication cost of Perovskite Solar Cells, PSCs, before commercial up-scaling. Scientists all over the world are working towards solutions and

Background and aims: TCF7L2 is both an activator and an inhibitor of transcription and the most highly associated type 2 diabetes gene known to date. It influences beta cell survival and function, i.e. incretin hormonal effects, insulin processing and secretion. However, its target genes in pancreatic islets are not fully described and the molecular mechanism whereby it propagates its effects on i

NETs (neutrophil extracellular traps) have been described as a fundamental innate immune defence mechanism. During formation of NETs, the nuclear membrane is disrupted by an as-yet unknown mechanism. In the present study we investigated the role of human cathelicidin LL-37 in nuclear membrane disruption and formation of NETs. Immunofluorescence microscopy revealed that 5 μM LL-37 significantly fac

The bioactivity, biological fate and cytotoxicity of nanomaterials when they come into contact with living organisms are determined by their interaction with biomacromolecules and biological barriers. In this context, the role of symmetry/shape anisotropy of both the nanomaterials and biological interfaces in their mutual interaction, is a relatively unaddressed issue. Here, we study the interacti

In this thesis we discuss the assembly of thermoresponsive microgel particles into small clusters, and their use as colloidal molecules with specific and directional interactions. The underlying goal is to use these particles as advanced building blocks for new types of self- assembled structures with novel or vastly improved properties, and as model particles for investigating fundamental problemIn this thesis we discuss the assembly of thermoresponsive microgel particles into small clusters, and their use as colloidal molecules with specific and directional interactions. The underlying goal is to use these particles as advanced building blocks for new types of self- assembled structures with novel or vastly improved properties, and as model particles for investigating fundamental problem

Eukaryotic cells employ the RNA interference (RNAi) machinery in the cytosol to downregulate gene expression. Short 21-nucleotide microRNAs (miRNAs) associate with the so-called RNA induced silencing complex (RISC) and hybridize with the target gene’s mRNA, preventing it from being translated into protein. Employing the RNAi machinery with synthetic small interfering RNAs (siRNAs) that mimics the

IGF-1 is an essential regulator of fetal growth and brain development. Preterm birth in the human is followed by a rapid decrease in serum levels of IGF-1 and decreased levels of IGF-1 have been associated with development of severemorbidity. A recent clinical trial indicated that supplementation with IGF-1 prevented development of severe intraventricular hemorrhage (IVH) in extremely preterm infa

Popular Abstract in Swedish Kväveoxid (NO) och framför allt kolmonoxid (CO) tillhör de giftigaste gaserna man känner till. Vem har inte läst i kriminalromaner om hur människor stängts in i garage och gasats ihjäl med kolmonoxid från arbetande bilmotorers avgasutsläpp. Under det senaste årtiondet har man kunnat visa att dessa gaser i själva verket bildas i vår egen kropp och att de utgör signalmoleDuring the last decade it has been shown that nitric oxide (NO) and carbon monoxide (CO) are produced in our own body, and that they constitute a novel class of messenger molecules. In 1992 a constitutive NO-producing NO-synthase (cNOS) was found in the islets of Langerhans, and in 1997 we could show for the first time that the islets also contained a CO-producing constitutive heme oxygenase (HO-2

Toll-interleukin-1 (Toll-IL-1) receptor signaling may play a key role in the development of airway hyperreactivity (AHR) and chronic airway inflammatory diseases such as asthma. Previously, we have demonstrated that pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), induce AHR. However, the underlying intracellular signaling mechanisms that lead t

Popular science summary The effect of glucose and incretin proteins on insulin secretion and OPN production Insulin secretion is a sensitive cellular process with ramifications in diabetes mellitus development. Diabetes mellitus is characterized by hyperglycemia, a chronic condition defined by high levels of circulating glucose. Insulin hormone is the primary regulator of glucose absorption from

Mechanisms of Colorectal Cancer Metastasis – Biology Education Skip to content About this blog Contact Accessibility Search Search Close Menu Biology Education Department of Biology | Lund University Mechanisms of Colorectal Cancer Metastasis Colorectal cancer (CRC) is the third most common cancer worldwide, and liver metastasis is a major cause of CRC-related mortality. Our research group at the

https://biologyedu.blogg.lu.se/project-mechanisms-of-colorectal-cancer-metastasis/ - 2026-10-05

Goal direction behavior and its neuronal organization – Biology Education Skip to content About this blog Contact Accessibility Search Search Close Menu Biology Education Department of Biology | Lund University Goal direction behavior and its neuronal organization To navigate effectively, an animal must align its body with its intended target and adjust its course as needed. In insects, this criti

https://biologyedu.blogg.lu.se/goal-direction-behavior-and-its-neuronal-organization-2/ - 2026-10-05

The activation of G Protein-Coupled Receptor 56 (GPR56), also referred to as Adhesion G-Protein-Coupled Ceceptor G1 (ADGRG1), by Collagen Type III (Coll III) prompts cell growth, proliferation, and survival, among other attributes. We investigated the signaling cascades mediating this functional effect in relation to the mitochondrial outer membrane voltage-dependent anion Channel-1 (VDAC1) expres

We report on the influence of selected components and their mixtures on the development of the morphology during drying of single droplets and extend the results to the morphology of whole milk powder particles. Sessile single droplet drying and acoustic levitation methods were employed to study single droplet drying. The influence of carbohydrates (lactose and maltodextrin DE12) and proteins (mic

https://www.ludc.lu.se/sites/ludc.lu.se/files/en_wp_airyscan-detector.pdf - 2026-10-06

Biological membranes and human interfaces are maintained under non-equilibrium conditions, where they are constantly exposed to different stimuli. The aim of this work is to advance our knowledge of human interfaces and evaluate how they respond to stimuli they naturally encounter, such as fluctuations in external humidity conditions, temperature, or UVB irradiation. In the first part of this thes

Background: Atopic dermatitis (AD) is characterized by an increased susceptibility to skin infections. Staphylococcus aureus is reported to dominate in AD lesions and reports have revealed the presence of staphylococcal biofilms. These infections contribute to aggravation of the eczema. Sodium hypochlorite is known to reduce bacterial load of skin lesions, as well as disease severity, in patients