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Graft polymerization of glycidyl methacrylate onto the pore surface of polyacrylamide macroporous gel was implemented in DMSO-aqueous solution using diperiodatocuprate(III) complexes as an initiator. The grafting densities up to 410% were achieved. The graft polymerization was confirmed by gravimetrical methods and FTIR. The graft polymerization of polymer inside the pores of the macroporous gel r
Immunotherapy has brought hope for cancer treatment, but its clinical success remains limited. Recently, overexpression of the transcription factors PU.1, IRF8 and BATF3 (PIB) was shown to induce direct reprogramming of tumor cells into antigen-presenting type 1 conventional dendritic cells (cDC1s), a rare subset of immune cells with pivotal role in anti-cancer immunity. This strategy might open a
Aims/hypothesis: Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigger NOD-like receptor pyrin domain containing-3 (NLRP3) inflammasome activation. C4b-binding protein (C4BP), present in serum, binds to IAPP and affect
Microencapsulation by spray drying of oil-in-water (o/w) emulsions provides a means to encapsulate functional lipophilic ingredients. The active ingredient is dispersed in continuous solid phase providing protection. However, the encapsulation efficiency depends on the microstructure and morphology of the dry particles influenced by several mechanisms occurring during processing such as oil drople
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Utvecklingen av nya innovativa chokladprodukter har tagit fart under de senaste åren i takt med att konsumenterna ställer allt högre krav på chokladkvaliteten. Eftersom produktionsprocessen är komplicerad och hållbarhetstiden begränsad uppskattas att man slänger drygt 100 000 ton chokladprodukter varje år i Europa till ett värde av 1.Abstract Fat bloom on chocolate is a major problem for the confectionery industry since the unappetising appearance and negative sensory effects lead to rejection by customers. The presence of fat bloom on chocolate confectionery systems is usually connected to migration of liquid fat due to the difference in composition between filling triacylglycerols (TAGs) and cocoa butter TAGs. The filling T
RNA architectonics offers the possibility to design and assemble RNA into specific shapes, such as nanoscale 3D solids or nanogrids. Combining the minute size of these programmable shapes with precise positioning on a surface further enhances their potential as building blocks in nanotechnology and nanomedicine. Here we describe a bottom-up approach to direct the arrangement of nucleic acid nanost
LUDC-IRC Postdoctoral Program 2020 – Project 3 LUDC-IRC Postdoctoral Program 2020 – Project 3 Role of intracellular C3 in homeostatic autophagy and survival in pancreatic β-cells PI: Anna Blom Co-PI: Erik Renström Purpose and aims To investigate the function of intracellular C3 within pancreatic β-cells, in cytoprotective autophagy. • Firstly, to investigate blood glucose homeostasis in a new nove
https://www.ludc.lu.se/sites/ludc.lu.se/files/blom_project_3.pdf - 2026-10-06
The work presented in this dissertation is concerned with the microstructures and surface roughness of test slabs of Ti-6Al-4V produced by one of powder based Additive Manufacturing (AM) technique namely electron beam melting (EBM). The effects of process parameters of a EBM system and geometry factors of a EBM build such as slabs’ thickness and height etc. on the microstructure and the surface ro
Powder structure and functionality are expected to be closely linked to the composition and drying process. In order to understand the optimization of the quality of a powder, e.g. encapsulation efficiency, or wetting and dispersion properties, monitoring of the particle microstructure is an attractive concept. However, to study the impact of different parameters in formulation and drying process
Här hittar ni de "Prova på aktiviteter" och workshops som ni har möjlighet att anmäla er till under UniStem-eftermiddagen. Populärvetenskapliga bilder av stamceller Ansvarig: Kristofer Hansson, Ellen Suneson (Institutionen för kulturvetenskaper) Antal studenter: ca 15 Beskrivning: Genom TV, tidningar och internet möter allmänheten de biomedicinska forskarnas framsteg inom dagens stamcellsforskning
https://www.stemcellcenter.lu.se/research-school/program-overview/public-engagement/unistem2015/workshops - 2026-10-05
Epilepsy is a severe chronic neurological disorder characterized by recurrent spontaneous seizures. Excitatory/inhibitory (E/I) imbalance, neuronal loss, brain inflammation, and altered adult neurogenesis are some of the characteristic hallmarks of epilepsy. Seizures increase the production of new hippocampal neurons but their function in the epileptic brain is still not fully understood. Elucidat
Collect data faster with new system – Biologibloggen Hoppa till huvudinnehåll Om Biologibloggen Tillgänglighet Kontakt Sök Sök Stäng Meny Biologibloggen Biologiska institutionen | Lunds universitet Collect data faster with new system Finally, our new confocal microscope (Leica SP8 DLS) has arrived in the department and is being installed by Leica technicians. The existing confocal mic (from 2003)
https://biologi.blogg.lu.se/collect-data-faster-with-new-system/ - 2026-10-06
The human melanocortin 4 receptor (MC4r) was successfully expressed in Sf9 cells using the baculovirus infection system. N- and C-terminally His-tagged receptors generated B-max values of 14 and 23 pmol receptor/mg membrane protein, respectively. The highest expression level obtained with the C-terminally His-tagged MC4r corresponded to 0.25 mg active receptor/litre culture volume. Addition of a v
Several millions of people worldwide are affected by bowel diseases and necessitate gastrointestinal surgery. Anastomosis is the union of two healthy ends of the bowel achieved by suture or stapling. One of the most feared complications after surgery are anastomotic leaks which occur in around 10 % of patients. The unintended breakdown of the newly created connection can lead to leakage of digesti
Popular Abstract in Swedish Stroke hos unga vuxna råttor och möss utlöser neurogenes i den skadade regionen striatum samt i den intakta hippocampus, men eftersom stroke framförallt drabbar äldre individer, är det av största vikt att utröna åldrandets effekt på hjärnans mekanismer för återhämtning. Gamla och unga vuxna råttor inducerades med stroke genom transient ocklusion av mellersta hjärnartäreStroke in young adult rodents triggers neurogenesis in the damaged striatum and intact hippocampus. as stroke happens frequently in aged individuals it is of great importance to know whether aging affects brain recovery mechanisms. Aged and young adult rats were subjected to stroke by transient occlusion of the middle cerebral artery and proliferating cells were labeled by intraperitoneal administ
Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated β-amyloid (Aβ) 40/42(43) peptides. Evidence implicates a central role for Aβ in the pathophysiology of AD. Mutations in βAPP and presenilin 1 (PS1) lead to elevated secretion of Aβ, especially the more amyloidogenic Aβ42.
Gut-associated lymphoid tissues (GALT) serve as key priming sites for intestinal adaptive immune responses. Most of our understanding of GALT function and development arises from studies in mice. However, the diversity, structure and cellular composition of GALT differs markedly between mammalian species and the developmental window in which distinct GALT structures develop in large mammals remain
