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Mitochondria are most known as producers of ATP and for their metabolic functions in eukaryotic cells. However, these are not the only roles of these organelles, as they also have the means to communicate with the nucleus. These signals going from mitochondria to the cell nucleus are termed mitochondrial retrograde signaling or regulation (MRR). In Arabidopsis thaliana, the master regulator of MRR
Clinical and experimental results have revealed a fundamental role of calcitonin gene-related peptide (CGRP) in primary headaches. CGRP is widely expressed in neurons both in the central nervous system (CNS) and in peripheral sensory nerves. In the CNS there is a wide distribution of CGRP-containing neurons with the highest levels seen in striatum, amygdale and cerebellum. Moreover, in acute attac
Superporous agarose beads have wide, connecting flow pores allowing large molecules such as plasmids to be transported into the interior of the beads by convective flow. The pore walls provide additional surface for plasmid binding thus increasing the binding capacity of the adsorbent. Novel superporous agarose anion exchangers have been prepared, differing with respect to bead diameter, superpore
Background: Myofibroblasts, proposed as being derived from circulating fibrocytes, are considered to be important cells in thickening of the basement membrane in patients with asthma. We have studied the correlation of tissue fibrocyte levels to basement membrane thickness and the presence of fibrocytes in bronchoalveolar lavage fluid (BALF) in steroid-naive patients with mild asthma and controls.
BACKGROUND: The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial pulsatility and astrocytic aquaporin-4 (AQP4) expression, facilitates much of this brain clearance. During the last decade, several observations hav
We conduct Metropolis Monte Carlo simulations on models of dilute colloidal dispersions, where the particles interact via isotropic potentials of mean force (PMFs) that display a long-ranged repulsion, combined with a short-ranged and narrow attraction. Such systems are known to form anisotropic clusters. There are two main conclusions from this work. First, we demonstrate that the width of the at
Objective: Ependymin-Related Protein 1 (EPDR1) was recently identified as a secreted human batokine regulating mitochondrial respiration linked to thermogenesis in brown fat. Despite that EPDR1 is expressed in human pancreatic β-cells and that glucose-stimulated mitochondrial metabolism is critical for stimulus-secretion coupling in β-cells, the role of EPDR1 in β-cell metabolism and function has
Super-Resolution Structured Illumination Microscopy (SR-SIM) provides resolutions down to 120 nm, allowing visualization of individual herpesvirus capsids (HSV-1) attached to the nucleus (HSV-1 C-capsid diameter is 125 nm). Figure: Imaging of reconstituted capsid-nuclei system confirms specific capsid binding to the NPCs at the nuclear membrane. Representative super-resolution SIM image showing G
Background: The bladder exstrophy-epispadias complex (BEEC) is a congenital malformation of the bladder and urethra. The underlying causes of this malformation are still largely unknown; however, aside from environment, genetics is thought to play an essential role. The recurrent 22q11.2 microduplication is the most persistently detected genetic aberration found in BEEC cases. Methods: We performe
Several significant pathogenic bacteria exhibit surface proteins that bind human antibodies, preventing them from being recognized by the human immune system. These bacteria are thus protected from elimination and can survive in the host organism. One common such bacteria is the Streptococcus pyogenes that exhibits the antibody binding M protein on its surface. Streptococcus pyogenes causes more t
Popular Abstract in Swedish Människans blod cirkulerar runt i kroppen genom dess många blodkärl. Blodkärlen är till största del uppbyggda av två slags celler; endotelceller och glatta muskelceller. Endotelcellerna är placerade innanför de glatta muskelcellerna i blodkärlet och deras uppgift är att forma en barriär mot blodet. De glatta muskelcellernas funktion är att reglera blodflödet genom blodkContraction of blood vessels for the regulation of blood flow and pressure is dependent on vascular smooth muscle cells (VSMC) located in the medial layer of the vascular wall. Adult, differentiated VSMC have a well developed contractile system and a low rate of proliferation. Under the influence of hormones, growth factors, inflammatory mediators and tissue factors, cells may modulate to a ”synth
Matrix metalloproteinase-9 (MMP-9) regulates platelet shedding of CD40L in abdominal sepsis. However, the signaling mechanisms controlling sepsis-induced shedding of CD40L from activated platelets remain elusive. Rac1 has been reported to regulate diverse functions in platelets; we hypothesized herein that Rac1 might regulate platelet shedding of CD40L in sepsis. The specific Rac1 inhibitor NSC237
The possible implication of the gasotransmitters NO and CO for the development of diabetes remains unresolved. Our previous investigations in rodents suggested NO being inhibitory, and CO stimulatory, to glucose-stimulated insulin secretion (GSIS). Here we studied the possible role of these gasotransmitters in both murine and human type 2 diabetes (T2D) by mapping the expression pattern of neural
Background: Absence seizures (petit mal seizures) are characterized by a brief loss of consciousness without loss of postural tone. The disease is diagnosed by an electroencephalogram (EEG) showing spike–wave discharges (SWD) caused by hypersynchronous thalamocortical (TC) oscillations. There has been an explosion of research highlighting the role of astrocytes in supporting and modulating neurona
Selective degradation of mitochondria by autophagy (mitophagy) is thought to play an important role in mitochondrial quality control, but our understanding of which conditions induce mitophagy in plants is limited. Here, we developed novel reporter lines to monitor mitophagy in plants and surveyed the rate of mitophagy under a wide range of stresses and developmental conditions. Especially carbon
Microglial neuroinflammation The inflammatory response in the brain, neuroinflammation, is implicated in many brain disorders. Several studies suggest that neuroinflammation contributes to disease progression. Our main research focus is to investigate the role of neuroinflammation in the diseased and healthy brain. Microglia are the major immune cells in the brain. Therefore, the majority of our p
https://www.neuroinflammation.lu.se/research-areas - 2026-10-05
Optical microscopy The division has a Zeiss Axioplan Universal microscope equipped with differential interference contrast and a High Resolution Microscopy Camera AxioCam MRm Rev. 3 FireWire, Illuminator HBO 100 as well as with a 100W mercury short-arc lamp and a system of filters to allow the fluorescence microscopy observations. The microscope is further equipped with a high-sensitivity SIT vide
https://www.physchem.lu.se/infrastructure/microscopy - 2026-10-05
Pradeep Kumar – new postdoc – Biologibloggen Hoppa till huvudinnehåll Om Biologibloggen Tillgänglighet Kontakt Sök Sök Stäng Meny Biologibloggen Biologiska institutionen | Lunds universitet Pradeep Kumar – new postdoc I am a Postdoctoral Researcher in the Department of Biology, Division of Evolution, at Lund University, working with Professor Jessica Abbott in the SexGen (Genetics of Sex Differenc
https://biologi.blogg.lu.se/pradeep-kumar-new-postdoc/ - 2026-10-05
