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Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin and is characterized by intraneuronal inclusions and widespread neuronal death at the late stage of the disease. In research, most of the emphasis has been on understanding the cell death and its mechanisms. Until recently, it was believed that the vast majority, if not all, of the symptoms in HD are a direc
Some elements have toxic effects on the human body and there is thus a need to control their levels in human organs and tissues. Moreover, it is important to increase our knowledge of relationships between observable toxic effects and element concentrations in man and his environment. Monitoring and basic occupational and environmental research rely on measurements directly in humans as well as sa
In October 2004, a free-living Stock Dove (Columba oenas) was found infected with Trichomonas spp. in the district of Soest, North Rhine- Westphalia, Germany. A huge buccal nodular lesion caused an occlusion of the esophagus and an external swelling. The bone of the mandibula was already softened and nearly solubilised. The microscopical examination of a wet swab sample from the carcass detected T
The very large multiplicity of charged particles encountered in lead on lead collisions in the WA98 experiment at the CERN SPS provided new experimental challenges. Tracking detectors read out with high granularity were developed to achieve accurate position information in two dimensions, with the aim of reconstructing tracks with a minimum of combinatorial difficulties. A tracking system based on
The properties of water in biological systems have been studied for well over a century by a wide range of physical techniques, but progress has been slow and erratic. Protein hydration-the perturbation of water structure and dynamics by the protein surface-has been a particularly rich source of controversy and confusion. Our aim here is to critically examine central concepts in the description of
Atmospheric mercury species/fractions were measured near a chlor-alkali plant in Sweden during August 28 to September 4, 2001. The concentration of total gaseous mercury in the plume from the plant was measured using TEKRAN and GARDIS instruments. Gaseous elemental mercury was measured using a light detection and ranging (LIDAR) technique. From vertical LIDAR sweeps through the plume from the chlo
Previous photorefractive results from harbour seals indicated the presence of a multifocal lens. This was surprising because the evolution of multifocal lenses has served to compensate for chromatic aberration in animals with colour vision, which harbour seals as monochromats should not be capable of. To gain insight into the lens optics of these animals, we extended our photorefractive measuremen
Infants gradually learn to predict the motion of moving targets and change from a strategy that mainly depends on saccades to one that depends on anticipatory control of smooth pursuit. A model is described that combines three types of mechanisms for gaze control that develops in a way similar to infants. Initially, gaze control is purely reactive, but as the anticipatory models become more accura
A numerical investigation to determine the velocity and heat transfer characteristics of multiple impinging slot jets in rib-roughened channels in the presence of cross-flow has been carried out. Fluid flow is modeled using an explicit algebraic stress model. A simple eddy diffusivity and a generalized gradient diffusion hypothesis are applied for the modeling of turbulent heat fluxes. The computa
Results related to time-mean pressure distributions around a circular cylinder in cross-flow are presented and discussed briefly with special emphasis on the effect of relative pressure hole size and the position of separation. Experiments cover Reynolds numbers from $0.2 imes 10^3$ to $2.1 imes 10^5$.
Abstract is not available
Popular Abstract in Swedish Tjocktarmcancer är en av de vanligaste cancerformerna i västvärlden. I Sverige drabbas årligen ca 5000 människor. Ungefär 10% av fallen går att härleda till ärftliga faktorer medan den övervägande delen orsakas av miljöfaktorer. Kända riskfaktorer är fysisk inaktivitet, fetma och rökning. Risken för cancer påverkas dock mest av den kost vi äter. Allmänt kan sägas att enSphingomyelin (SM) is present both in eucaryotic cells and the diet. Sphingomyelinase (SMase) hydrolyses SM and generates ceramide that has been implicated in the regulation of cell growth, differentiation and apoptosis. Previously a SMase with alkaline pH optimum was identified in the intestinal tract. The thesis studied the distribution pattern, the species difference and the clinical implicatio
In this grounded theory study, the authors interviewed caregivers andpatients in end-of-life cancer care and found Balancing to be a fundamentalprocess explaining the problem-solving strategies of most participants and offering a comprehensive perspective on both health care in general and end-of-life cancer care in particular. Balancing stages wereWeighing— sensing needs and wishes signaled by pa
The aim of this work is to propose a framework for providing QoS routing in MANETs. The proposed framework uses local information of nodes such as node's speed, buffer, and power to select path for routing. Deploying these information, more stable paths are selected and hence QoS routing parameter could be satisfied. Moreover, routing performance has been improved, especially in terms of end-to-en
The site–site Ornstein–Zernike equation with a simple mean spherical closure is used to study electrostatic interactions of proteins. Using a Debye–Hückel approximation for the correlation functions of the bulk electrolyte and a simple basis expansion for the protein–salt direct correlation functions, we obtain a very simple variational expression for the electrostatic component of the excess chem
The question of what makes ‘Nordic’ music distinctive is a matter of some dispute. Does it exist? Or, in what ways is it able to manifest itself? Like nationality, it is a construction of identity that emerges through discourses on music and on Nordicness. Essentially it is an open signifier, as concepts of Nordicness can be identified either with something dark, cold and obscure or as something r
