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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 194604 hits

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Terrorism has for centuries been used as a leverage to attain political, social and economic goals. It is no new phenomena, but since the September 11th attacks of 2001 the American And British governments have instigated a new global ?war? against terrorism. The ?war against terror? discourse that the British and American governments seek to uphold provides a smokescreen from behind which the UK

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Key recommendationsPastureland restoration must be implemented to reduce dependency oncoping mechanisms such as emergency feeding, mechanized transport andintense workloads. These coping mechanisms are increasingly used to dealwith the cumulative effects of encroachments from competing land uses,predator pressure, and the impacts of climate change on snow conditions.Vigorous thinning of dense, man

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Background: Despite a good prognosis, survivors of differentiated thyroid cancer (DTC) may have reduced health-related quality of life (HRQOL) many years after treatment, and it is unclear how suppression of thyroid-stimulating hormone (TSH) may contribute to HRQOL. This study investigated changes in HRQOL in the 5 years following DTC treatment, the association between HRQOL and TSH suppression, a

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Featured Application: Evaluating the effect of train impact velocity, pedestrian position, and station environment on head injury and run-over risk. Application to future safety device design. Introduction: Subway–pedestrian collisions are a significant and growing problem, but they are poorly understood. This study presents the first subway–pedestrian collision model with the aim of evaluating th

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Coronavirus disease 2019 (COVID-19) is a contagious disease that turned into a pandemic and led to seven million deaths around the globe. A herculean effort was made by world scientific community to develop various therapies including vaccines against COVID-19 in record time. Use of nanomedicine was one among the different treatment strategies tried against COVID-19. Nanocarriers were effectively

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Background: About one in ten adults are living with diabetes worldwide. Intake of carbohydrates and carbohydrate-rich foods are often identified as modifiable risk factors for incident type 2 diabetes. However, strong correlation between food variables can make it difficult to identify true associations. The purpose of this study was to identify clusters of carbohydrate-rich foods and analyse thei

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Background: Treating violent behavior in prisons comes with challenges, such as the inability to practice safely with triggering situations and motivational issues. A solution may be the use of Virtual Reality (VR). With VR, specific conditions or needs can be tailored for individual practice, it can enhance motivation and VR has proven to be a safe and effective tool in mental health treatment. O

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This data package contains high accuracy CO2 dry air mole fractions from 58 ICOS and non-ICOS European observatories at in total 132 observation levels, collected by the ICOS Atmosphere Thematic Centre (ATC) and provided by the station contributors. The package is part of the Globalviewplus v8.0 data product, released in 2022 and is intended for use in carbon cycle inverse modeling, model evalua

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Quantification of land surface-atmosphere fluxes of carbon dioxide (CO2) and their trends and uncertainties is essential for monitoring progress of the EU27+UK bloc as it strives to meet ambitious targets determined by both international agreements and internal regulation. This study provides a consolidated synthesis of fossil sources (CO2 fossil) and natural (including formally managed ecosystems

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Impacts of elevated tropospheric ozone on mountain birch leaves reveals higher vulnerability in young leaves compared to old. The leaf recovery after high concentration exposure is affected with lower photosynthetic rate and increased stress-related sesquiterpene emissions.

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This review highlights the importance of model-based approaches in accelerating vaccine manufacturing process development. The challenges of scaling up from laboratory to commercial processes are addressed through the adoption of Process Analytical Technology frameworks and Quality by Design principles. The application of various modeling approaches beyond downstream and upstream processes in vacc

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Riparian buffer zones (RBZs) are an important instrument for environmental policies for water and biodiversity protection in managed forests. We investigate the variation of the cost of implementing RBZs within different property size classes across the size range of non-industrial forest owner properties in Southern Sweden. Using the Heureka PlanWise decision support system, we quantified the cos

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Articular cartilage and meniscus transfer and distribute mechanical loads in the knee joint. Degeneration of these connective tissues occurs during the progression of knee osteoarthritis, which affects their composition, microstructure, and mechanical properties. A deeper understanding of disease progression can be obtained by studying them simultaneously. Time-resolved synchrotron-based X-ray pha

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Spondyloarthritis (SpA) has been associated with comorbidities, e.g., cardiovascular disease. However, little is known about the relation between SpA and chronic obstructive pulmonary disease (COPD). The aim of the study was to compare the prevalence of COPD in SpA to the general population. Patients with prevalent SpA in Skåne, Sweden, on December 31, 2018, were identified based on diagnostic cod

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Pancreatic cancer is often detected at a late stage and usually leads to significant morbidity and deaths1. The 5-year survival rate for those with pancreatic cancer detected at a resectable stage is 25%, compared with a 5-year survival rate of 3% for those with pancreatic cancer that is not resectable2–4. Some 20% of patients have resectable disease at the time of diagnosis, underscoring the nece

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Objective: To identify subgroups of patients with magnetic resonance imaging (MRI)-confirmed degenerative meniscus tears who may benefit from arthroscopic partial meniscectomy (APM) in comparison with non-surgical or sham treatment. Methods: Individual participant data (IPD) from four RCTs were pooled (605 patients, mean age: 55 (SD: 7.5), 52.4% female) as to investigate the effectiveness of APM i

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This article examines forced migrants’ decision-making over time on movement from first country of asylum. Building on 150 in-depth interviews with Syrian refugees (A note on terminology: the term refugee is used colloquially by our participants, other scholars, the legal profession, and international actors to denote most Syrian migrants, yet it often means different things to its users. While ma

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Global environmental change is not just a bio-physical reality. It has affective, relational, and existential dimensions that influence people. Artistic methods can be used in research to communicate about or disseminate global environmental change and explore people’s emotions about and sense-making of global environmental change. While often positioned as a mode of outreach, this presentation re