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Inhibition of polyamine synthesis influences contractility of intestinal smooth muscle in culture

Smooth muscle strips from guinea pig ileum were cultured for 5 days and then tested for contractile properties to investigate whether endogenous polyamines influence excitation-contraction coupling. Inhibition of spermidine and spermine synthesis by culture in the presence of the adenosylmethionine decarboxylase (EC4.1.1.50) inhibitor CGP-48664 (1-10 microM) decreased spermidine and spermine level

Country of birth and socioeconomic disparities in utilisation of health care and disability pensions - a multilevel approach

Popular Abstract in Swedish Det är känt att låg socioekonomisk position (t.ex., låg inkomst, kort utbildning) och civilstånd, (t.ex., ensamstående) kan försämra hälsan. Den sämre hälsan medför ett ökat sjukvårdsbehov, och i ett jämlikt samhälle borde därför sjukvårdsutnyttjandet vara större bland de med låg socioekonomisk position och bland de som är ensamstående. Av samma anledning bör en högre fBesides individual characteristics, people born in the same country may present a related pattern of health status and health care utilisation, perhaps because they share a number of socioeconomic and cultural characteristics in addition to their common geographic origin and language. Rather than using simple ethnical or geographical categories, we apply multilevel regression analysis with individ

Effects of 2,3-butanedione monoxime on activation of contraction and crossbridge kinetics in intact and chemically skinned smooth muscle fibres from guinea pig taenia coli

The effects of 2,3-butanedione monoxime (BDM) were studied in smooth muscle fibres from guinea pig taenia coli. In intact muscle, active force during contractions induced by high-K+ was inhibited by about 10% in 1 mM BDM and by approximately 70% in 10 mM BDM. Intracellular [Ca2+] during contraction, measured with the fura-2 technique, was reduced in the presence of BDM. The reduction in force and

The Possibility of Resonance-Enhanced Two-Photon Ionization of Ne and Ar Atoms in Astrophysical Plasmas

We consider possible schemes for the resonance-enhanced two-photon ionization (RETPI) of Ne and Ar atoms under the action of bichromatic radiation of intense resonance lines of HI, HeI, and HeII in a radiation-rich astrophysical plasma. The ionization rate is comparable to or exceeds the recombination rate in rarified astrophysical plasma, which leads to the accumulation of singly ionized ions wit

Young children's representations of peers' distress: Associations to children's social functioning and acceptance of distressed peers

Children's mental representations of situations involving another child's distress were examined in two studies. Study 1 examined 3- to 7-year-old children's (n = 44) ideas about what victims and bystanders would think, feel and do in hypothetical situations. In Study 2, 7- to 8-year-olds (n = 40) described their own cognitive response to situations in which they were confronted with another's dis

Exercise may induce reversible low bone mass in unloaded and high bone mass in weight-loaded skeletal regions

Exercise during growth and adolescence increases bone mineral density (BMD) in weight-loaded skeletal regions. The development of BMD in unloaded or minimally loaded regions during activity is unclear. We measured BMD in one unloaded, one partly loaded and one highly loaded skeletal region in 67 active soccer players, mean age 22.7 years (range 17-35 years), 128 former soccer players, mean age 54.

Tunneling spectroscopy of modulated two-dimensional electron systems

We discuss the tunneling between two parallel modulated two-dimensional electron systems in tilted magnetic fields. The electronic states are described in terms of the magnetic crystal momentum, and tunneling events connect the states whose momenta differ by a shift due to the in-plane component of the field. We use this fact to develop a theory of how the features of the artificial two-dimensiona

A simple analysis of thermodynamic properties for classical plasmas: II. Validation

The generalized hole corrected Debye-Huckel theory (Penfold et al J. Stat. Mech. (2005) P06009) is implemented. Predictions of thermodynamic functions and simple structural properties compare favourably with results from closure of the Ornstein-Zernike integral equation in the mean spherical approximation, and with Monte Carlo simulation of the charged hard sphere primitive model. A strictly nonel

Supination-eversion fractures of the ankle joint: changes in incidence over 30 years

The sex- and age-specific incidence has been calculated for ankle fractures from the first part of the 1950s and compared with the 1980s, a 30-year interval. The fractures were also classified according to Lauge-Hansen. Altogether 1784 fractures were found. During that time interval ankle fractures had become more common, particularly those with extensive skeletal involvement, such as the stage IV