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BACKGROUND: Atrial fibrillation (AF) burden is associated with adverse outcomes; in some patients, very low AF burden may not be actionable.OBJECTIVE: This study aimed to model AF burden as a function of monitoring time without AF.METHODS: We included 11,639 US patients (median age 62 years [interquartile range 46‒73], 40.6% male) without permanent/persistent AF, monitored for ≥14 days in 2021 wit
The efficient clearance of IAPP oligomers (IAPPo) by autoantibodies is crucial as increased plasma levels of IAPPo can induce microvascular alterations and Alzheimer's disease (AD)-characteristic amyloid-β deposition in the brain. We have recently demonstrated that plasma immunoglobulin (Ig) A levels against IAPPo, but not IgG, are reduced in an Apolipoprotein E (APOE) ε4 allele dose-dependent man
BACKGROUND: Clinical practice guidelines are intended to help with decision-making. However, their quality differs. Guidelines of low quality are a waste of resources and can cause patient harm. We compared the quality of the Danish, Norwegian, and Swedish guidelines on papillary thyroid cancer (PTC) with those of the American Thyroid Association (ATA, 2015 version).METHODS: Three pairs of apprais
Malignant ventricular arrhythmias (VAs) are a major contributor to mortality in myocardial infarction. Although early revascularization has markedly reduced the incidence of late and secondary VA, the occurrence and fatality rates of VA during the prehospital stage remain high. In ST-segment elevation myocardial infarction, most VAs occur within the first 24 hours, with only a small proportion obs
Pilar leiomyoma is a rare benign tumour that derives from the arrector pili muscle. Due to its rarity, the dermatoscopic features of pilar leiomyoma are scarcely reported in the literature. Herein, we report a further case of pilar leiomyoma that highlights its dermatofibroma-like dermatoscopic features and underscores that, despite advances in noninvasive imaging technologies, histopathology rema
This paper analyses the effects of innovation policy on innovation output. We use a database of Swedish innovations (1970-2001), linked to both approved and non-approved public funding projects, and combine logistic regressions with matching approaches. We address: (1) the characteristics of firms applying for public funding, (2) the effects of public funding on the generation of significant innov
AIMS: Assessment of mitral valve (MV) function and haemodynamics is essential for optimizing surgical repair in children with mitral regurgitation. Patient-specific fluid-structure interaction (FSI) modelling can capture the complex interplay between valvular mechanics and blood flow. In this study, we apply a patient-specific FSI framework to evaluate MV function and haemodynamics in paediatric p
BACKGROUND: During the last decade chemotherapy recommendations have changed for patients with pancreatic adenocarcinoma (PDAC) as novel regimens demonstrate better survival in selected cohorts. Herein we aim to, in a regional cohort, analyse therapy changes and possible survival benefits over a 10-year period.METHODS: Patients in the southern region of Sweden diagnosed with pancreatic cancer betw
In this nationwide cohort study, we assessed the long-term risk of major cardiovascular events following intensive care unit (ICU) treatment for community-acquired sepsis and septic shock, compared to the general population. We included 20313 adults admitted to Swedish ICUs between 2008 and 2019, identified through national healthcare registries, and matched each case to 20 randomly selected popul
BACKGROUND: Pneumonia is a common infection that leads to frequent hospitalizations and primary healthcare visits. Previous smaller studies have indicated high prevalence of undiagnosed diabetes mellitus (DM) and increased subsequent risk of coronary heart disease (CHD) among patients with pneumonia. However, previous studies have not used nationwide data that include diagnoses from primary health
Collaborative innovation has emerged as a way to share risks and costs associated with the innovation process. However, identifying and establishing contact with suitable collaboration partners proves challenging. To overcome this barrier, knowledge brokers, such as innovation agencies or universities, can step in to bridge contacts between innovative firms. This paper provides a long-term case st
Donald Trump kan avskeda ämbetsmän och pressa centralbanken. Men finansmarknaden kan han inte avsätta. Tullreträtten i fjol visar varför marknaden kan fungera som en vakthund för demokratin, skriver Lars Jonung.
Background The objective of this study was to provide a multimodal biomarker characterization of amnestic objective subtle cognitive decline (obj-SCD) in aging and preclinical Alzheimer’s disease (AD). Methods Prospective observational study; data from the Alzheimer’s and Families+ (ALFAs+) cohort, including cognitively unimpaired (CU) individuals with available baseline CSF biomarkers (normal or
Background: Stroke is the second leading cause of death and the third leading cause of disability worldwide, with global economic costs exceeding US $890 billion annually and a projected 50% rise in deaths between 2020 and 2050. So far, stroke has been addressed within the World Health Organization (WHO) Global Noncommunicable Disease (NCD) Action Plan 2023–2030 and the Intersectoral Global Action
Background Obstructive sleep apnea (OSA) frequently coexists with coronary artery disease (CAD) and may contribute to heart failure with preserved ejection fraction (HFpEF). Whether HFpEF-like features are reversible with continuous positive airway pressure (CPAP) therapy remains uncertain. Methods A total of 177 revascularized CAD patients with nonsleepy OSA (Epworth Sleepiness Scale score <10; a
CD8 + T-cell presence and distribution in oropharyngeal cancer (OPC) reflects specific immune phenotypes and are linked to prognosis. Image processing methods such as convolutional neural networks (CNN) may enhance treatment decisions. From standard computed tomography (CT) images, this study evaluates radiomics in combination with machine learning models and CNN for prediction of spatially resolv
Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26;
The development of wide bandgap perovskite solar cells (WBG PSCs) holds significant promise for advancing tandem solar cells. However, the intrinsic rapid crystallization kinetics severely impedes the vertical-oriented growth and homogeneous film formation of perovskite crystals, leading to high defect density and compromised device performance. This work proposes an innovative molecular interfaci
