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This chapter discusses the purification of islets and cells from islets. The pancreatic islets that are composed of several hormone-producing cells can be isolated by collagenase digestion of the pancreas. The yield of islets relative to the total number is usually small. Sufficient number of islets for a variety of functional and biochemical studies can be obtained by gradient centrifugations or
Recent studies in Arabidopsis (Arabidopsis thaliana) have reported conflicting roles for NAC DOMAIN CONTAINING PROTEIN 17 (ANAC017), a transcription factor regulating mitochondria-to-nuclear signaling, and its closest paralog NAC DOMAIN CONTAINING PROTEIN 16 (ANAC016), in leaf senescence. By synchronizing senescence in individually darkened leaves of knockout and overexpressing mutants from these
A search for charged leptons with large impact parameters using 139 fb-1 of s=13 TeV pp collision data from the ATLAS detector at the LHC is presented, addressing a long-standing gap in coverage of possible new physics signatures. Results are consistent with the background prediction. This search provides unique sensitivity to long-lived scalar supersymmetric lepton partners (sleptons). For lifeti
Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of graft vs. host disease for children and young adults undergoing hematopoietic stem cell transplant (HSCT). However, international protocols rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks and cohort isolation or food
Background: Irradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several in vivo studies. Few cell lines have been investigated in vitro, and previous results are inconsistent. Assuming that oxygen depletion accounts for the FLASH sparing effect, no sparing should appear for cells irradiated with low doses in normoxia. Methods: Seve
Background: Treatment of mentally disordered offenders (MDOs) is challenging as their behavior and clinical conditions can be traced to a complex constellation of major mental disorders, substance use and antisocial lifestyle. Finding subgroups of these offenders, which could guide treatment and risk assessment, is desirable. There are few long-term, prospective studies of risk factors for persist
The high polymorphism of Major Histocompatibility Complex (MHC) genes is generally considered to be a result of pathogen-mediated balancing selection. Such selection may operate in the form of heterozygote advantage, and/or through specific MHC allele–pathogen interactions. Specific MHC allele–pathogen interactions may promote polymorphism via negative frequency-dependent selection (NFDS), or sele
Stock exchange trading increasingly has been highlighted as a possible cause of gambling disorder, typically in rapid and excessive “day trading” which may cause over-indebtedness and mental health problems. The COVID-19 pandemic has been suspected to increase online gambling and gambling problems. In a number of recent media reports, day trading has been reported to increase during COVID-19, poss
The density and modulus of elasticity (MOE) distribution can provide information on the effectiveness of parametric and non-parametric methods in calculating the characteristic value of MOE. In this study, we aim to determine the optimal distribution model of the actual measured data of the lumber. We also estimate the lumber’s MOE characteristic value and compare the difference in density and MOE
This chapter deals with the application of adhesives in timber engineering, including wood-based products. This work is aiming to describe the general subjects in wood gluing technology, which are characteristic to wood substrates. Firstly, an overview of the basic needs and prerequisites is given, followed by a brief overview of the characteristics of the wood material. An introduction to the gen
Glued-in rods are important connecting and reinforcing elements in modern timber engineering used in new and existing timber structures. The complex stress distribution along the bondline between rod and wood depends on the type and properties of the adhesive and the type of load application. In this chapter, different models for the determination of the shear stress distribution along the bondlin
Det stora träbyggandet har varit i blickfånget sedan våra byggregler ändrades i mitten av 1990-talet. En tydlig utveckling har skett vad gäller flervåningsbyggandet i trä. Användningen av trä i infrastrukturer som broar och vindkraftverk har också ökat, även om användningen av trä i sådana bärande utomhuskonstruktioner i allmänhet är blygsam. Genom att modifiera trä på kemisk väg kan många av de s
Presentation av pågående projekt.
Background and AimsP-Coumaric acid (PCA) is one the compound that has free radical scavenging effects. This study investigates the protective effect of PCA on tissue damage in DOX-induced nephrotoxicity.MethodsThirty two Wistar rats were divided into control, PCA, DOX (15 mg/kg, i.p.) and DOX plus PCA (100 mg/kg, orally) groups. DOX-induced nephrotoxicity was indicated by marked increase in blood
Acute as well as chronic pain syndromes are common after whiplash trauma and exercise therapy is proposed as one possible intervention strategy. The aim of the present systematic review was to evaluate the effect of exercise therapy in patients with Whiplash-Associated Disorders for the improvement of neck pain and neck disability, compared with other therapeutic interventions, placebo interventio
BackgroundEarly life factors influence the number of nephrons a person starts life with and a consequence of that is believed to be premature kidney ageing. Thus, we aimed to identify early life factors associated with cystatin C and creatinine-based estimated glomerular filtration (eGFR) rate equations and urine -albumin-to-creatinine ratio after a follow-up of 46–67 years.MethodsThe study includ
Svensk-kinesiska forskningssamarbeten ökar, men att förhålla sig till Kina kräver kunskap, transparens och kompass. Det skriver Tommy Shih och Sylvia Schwaag Serger vid Lunds universitet.
Performance is the yardstick by which the quality of individual and collective human effort is assessed. Everywhere, performance shapes the lives of people and organizations according to its logic and demands. The quest for performance has spread to societies worldwide; it has become of central importance for our perception of our activities and our understanding of the world. Such importance call
