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Routine endomyocardial biopsy (EMB) to detect acute cellular rejection (ACR) late (>1 year) after heart transplantation (HT) remains debated. To gain knowledge on late ACR and thereby approach this issue, we studied the incidence, predictors, and outcome of late ACR. 815 late EMBs from 183 patients transplanted 1988-2010 were retrospectively reviewed until June 30, 2012. Only 4.4% of the routine a

Background: There is a need for increased understanding of the pre-diabetic period in individuals with high risk of type 1 diabetes from the general population. Methods: High-risk children (n = 21) positive for multiple islet autoantibodies were identified by autoantibody screening within the All Babies in Southeast Sweden study. The children and their parents were enrolled in a 2-year prospective

A survey of four co-design tools for joint analysis, simulation, and design of computer-based control systems developed within the Swedish ARTES programme is presented. The tools allow simultaneous treatment of the control aspects and the computing and communication aspects of the control problems. The tools are Jitterbug and TrueTime developed at the Department of Automatic Control LTH, Lund Univ

The paper presents the control server, a real-time scheduling mechanism tailored to control and signal processing applications. A control server creates the abstraction of a control task with a specified period and a fixed input-output latency shorter than the period. Individual tasks can be combined into more complex components without loss of their individual guaranteed fixed-latency properties.

Background and aims: Pharmacotherapy can be an important part of the continuum of care for alcohol use disorder (AUD). The Swedish universal health-care system emphasizes provision of care to marginalized groups. The primary aim was to test associations of neighborhood deprivation and disadvantaged social status with receipt of AUD pharmacotherapy in this context. Design: Data from linked populati

The demand for developing creativity among doctoral students is found in a number of educational policies all over the world. Yet, earlier studies on Swedish doctoral education suggest that doctoral students’ creativity is not always encouraged. Based on a critical hermeneutic approach and cases in four different disciplines, the aim of this study was therefore (1) to explore different shapes of d

One of the key-principles of the iron-sulphur world theory is to bring organic molecules close enough to interact with each other, using the surface of pyrite as a substrate in a hydrothermal setting. The present paper explores the relationship of pyrite and organic matter in a hydrothermal setting from the geological record; in hydrothermal calcite veins from Carboniferous limestones in central I

In the 23-km-diameter Haughton impact structure, Canadian High Arctic, in sulfate-rich bedrock, widespread hydrothermal sulfide mineralization occurred in breccias formed during the impact. The sulfides exhibit extreme sulfur isotopic fractionation relative to the original sulfate, requiring microbial sulfate reduction by thermophiles throughout the crater. This evidence of widespread microbial ac

Limestone samples from the Cambro-Ordovician Durness Group were crushed, aciddigested and searched for evidence of micrometeorites. Eleven melted micrometeorites were extracted from the magnetic fraction of samples from the Balnakeil and Croisaphuill formations near the top of the group. Other formations in the Durness Group did not yield micrometeorites. Only melted spherules with a distinctive d

Impact-generated hydrothermal systems are commonly proposed as good candidates for hosting primitive life on early Earth and Mars. However, evidence of fossil microbial colonization in impact-generated hydrothermal systems is rarely reported in the literature. Here we present the occurrence of putative fossil microorganisms in a hydrothermal system of the 89 Ma Dellen impact structure, Sweden. We

On Earth, the deep subsurface biosphere of both the oceanic and the continental crust is well known for surviving harsh conditions and environments characterized by high temperatures, high pressures, extreme pHs, and the absence of sunlight. The microorganisms of the terrestrial deep biosphere have an excellent capacity for adapting to changing geochemistry, as the alteration of the crust proceeds

A Devonian siltstone from Orkney, Scotland, shows survival of biomarkers in high-velocity impact experiments. The biomarkers were detected in ejecta fragments from experiments involving normal incidence of steel projectiles at 5-6 km s-1, and in projectile fragments from impact experiments into sand and water at 2-5 km s-1. The associated peak shock pressures were calculated to be in the range of

The 39-2Ma Haughton impact structure on Devon Island comprises a thick target succession of sedimentary rocks, mainly carbonates. The carbonates contain pre-impact organic matter, including fossil biological markers. Haughton is located in an area where no major thermal event has affected the sedimentary succession after heating caused by impact. This makes Haughton uniquely suitable for studies c

In a series of experiments the pyrolytic effects of the heating induced during the hypervelocity impact (HVI) of small projectiles of high TOC mudrock were observed. Impacts at these high speeds (km s-1) release sufficient energy to vaporise metal projectiles, and the temperatures created greatly exceed the pyrolysis temperatures typically employed during laboratory studies of the thermal alterati

The Ordovician Lockne impact structure is located in central Sweden. The target lithology consisted of limestone and black unconsolidated shale overlaying a Precambrian crystalline basement. The Precambrian basement is uranium-rich, and the black shale is both uranium- and organic-rich. This circumstance makes Lockne a good candidate for testing the occurrence of U-Th-rich bitumen nodules in an im

Melt fragments in melt breccias from the Gardnos impact crater, Norway, contain abundant carbon. A high proportion of the carbon present in the original melt was preserved. The stripping of hydrogen from carbon during melting prevents later hydrocarbon formation, hence the carbon is fixed in place rather than volatilized. Underlying lithic breccias that were not melted record hydrocarbon generatio

The response of organic matter to high-temperature events is important to astrobiology, as it governs the survival of carbon during several processes that may be critical to the origin and spread of life. Impact cratering is a widespread high-temperature process. The behaviour of carbon during impact events is not well understood. But there is the potential to examine other examples of the respons

Graphitic carbon is a widespread precipitate in terrestrial and extraterrestrial samples. However it has a range of possible origins, which can be difficult to distinguish, including the in situ alteration of organic matter, thermal alteration of hydrocarbons, and precipitation from C-O-H fluids. Petrographic characteristics help to understand the origin of the graphite, including relationships wi