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Epoxide hydrolases are essential enzymes that convert epoxides into 1,2-diols, contributing to detoxification, metabolism, and signaling in a wide range of organisms. In this study, we employed hybrid quantum mechanics/molecular mechanics (QM/MM) calculations to investigate the catalytic mechanism of potato epoxide hydrolase 1 (StEH1), specifically focusing on the hydrolysis of trans-stilbene oxid
Quantum refinement (QR) is an approach in which the empirical restraints used in standard structural refinement to ensure that the details of the structure, e.g. bond lengths and angles, make chemical sense are replaced by more accurate quantum mechanical calculations for a small but interesting part of the structure. QR has previously been used for X-ray and neutron crystallography, cryogenic
Herein, we present a case of severe immune-related adverse events (irAEs), myocarditis with myositis, and myasthenia gravis overlap syndrome (IM3OS) in a patient receiving an immune checkpoint inhibitor (ICI), as adjuvant therapy after surgery for muscle-invasive bladder cancer. An 80-year-old woman who had undergone a total cystectomy for bladder cancer presented with ptosis, diplopia, and paraly
Aluminum is a promising carbon-free energy carrier, but advancing its use requires detailed understanding of its combustion behavior at the single-particle level. Measuring the transient surface temperatures of burning aluminum droplets is particularly challenging due to their small size, extreme temperatures, and fast dynamics. In this work, we demonstrate a multispectral pyrometry approach based
High-brightness electron bunches drive fundamental research in particle physics and photon science. Key to achieving a high brightness is to have a low transverse emittance, which ensures that the bunch can be tightly focussed. In radiofrequency accelerators a low initial emittance can be rapidly degraded due to space charge forces, which are greatly diminished once the electron bunch attains a re
Radio-frequency particle accelerators are engines of discovery, powering high-energy physics and photon science, but are also large and expensive due to their limited accelerating fields. Plasma-wakefield accelerators (PWFAs) provide orders-of-magnitude stronger fields in the charge-density wave behind a particle bunch travelling in a plasma, promising particle accelerators of greatly reduced size
For plasma-wakefield accelerators to fulfill their potential for cost effectiveness, it is essential that their energy-transfer efficiency be maximized. A key aspect of this efficiency is the near-complete transfer of energy, or depletion, from the driver electrons to the plasma wake. Achieving full depletion is limited by the process of re-acceleration, which occurs when the driver electrons dece
Detailed knowledge of particle-beam properties is of great importance to understand and push the performance of existing and next-generation particle accelerators. We recently proposed a phase-space tomography method to reconstruct the five-dimensional (5D) phase space, i.e., the charge density distribution in all three spatial directions and the two transverse momenta. Here, we present the first
FLASHForward is an experimental facility at DESY dedicated to beam-driven plasma-accelerator research. The X-2 experiment aims to demonstrate acceleration with simultaneous beam-quality preservation and high energy efficiency in a compact plasma stage. We report on the completed commissioning, first experimental results, ongoing research topics, as well as plans for future upgrades.
Economic policy instruments are commonly used to address environmental problems. This study examines the historical development of the carbon tax in Sweden. By using the concept of epistemic culture, this study shows how carbon emissions, rather than energy use alone, emerged as an object of taxation. While the leading politicians saw the carbon tax as an innovative instrument for demonstrating cl
Soil microorganisms regulate carbon (C) cycling, and their growth and respiration are strongly dependent on temperature. Yet it remains unclear how warming alters microbial thermal traits, community structure, and the balance between microbial respiration and growth, particularly in subtropical ecosystems where high temperatures coincide with low soil moisture, potentially constraining microbial a
In the years between 1915 and 1921, Harvard professor of Slavic Languages Leo Wiener (1862–1939) published a controversial and now largely forgotten series of philological studies which sought to prove that that all textual sources testifying to the languages, laws, customs, and beliefs of the ancient Germanic peoples had been forged in the eighth century C.E. by a group of Arabicized Goths in the
Background: General practitioners (GPs) do not see men with localised urinary tract infection (UTI) very often which limits their possibility of developing expertise in the area. To gain knowledge of male patients' experiences and perspectives on localised UTIs, qualitative research is needed.Aim: To explore expectations, experiences and symptoms in men with localised urinary tract infection in prBackgroundGeneral practitioners (GPs) do not see men with localised urinary tract infection (UTI) very often which limits their possibility of developing expertise in the area. To gain knowledge of male patients’ experiences and perspectives on localised UTIs, qualitative research is needed.AimTo explore expectations, experiences and symptoms in men with localised urinary tract infection in primar
