The influence of pH on the acute toxicity of NSAIDs (ketoprofen, diclofenac, naproxen and ibuprofen) towards Daphnia magna (water flea)
Abstract Ketoprofen, naproxen, diclofenac, and ibuprofen are four widelyused anti-inflammatory drugsthat areproduced in several kilotons each year.They end up in natural water recipients which couldvary inpH from around 6.0 to 9.0. Bearing in mind that most of thesepharmaceuticals are weak acids and therefore dissociates in different degree depending on surroundingpH and the chemical’s pKa, we ca