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Validation of the modified Skåne emergency department assessment of patient load (mSEAL) model for emergency department crowding and comparison with international models; an observational study

Background: Emergency Department crowding is associated with increased morbidity and mortality but no measure of crowding has been validated in Sweden. We have previously derived and internally validated the Skåne Emergency Department Assessment of Patient Load (SEAL) score as a measure of crowding in Emergency Departments (ED) in a large regional healthcare system in Sweden. Due to differences in

A/H1N1 hemagglutinin antibodies show comparable affinity in vaccine-related Narcolepsy type 1 and control and are unlikely to contribute to pathogenesis

An increased incidence of narcolepsy type 1 (NT1) was observed in Scandinavia following the 2009–2010 influenza Pandemrix vaccination. The association between NT1 and HLA-DQB1*06:02:01 supported the view of the vaccine as an etiological agent. A/H1N1 hemagglutinin (HA) is the main antigenic determinant of the host neutralization antibody response. Using two different immunoassays, the Luciferase I

A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive

Area and reconfiguration time minimization of the communication network in regular 2D reconfigurable architectures

n this paper, we introduce a constraint programming-based approach for the optimization of area and of reconfiguration time for communication networks for a class of regular 2D reconfigurable processor array architectures. For a given set of different algorithms the execution of which is supposed to be switched upon request at run-time, we provide static solutions for the optimal routing of data b

Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression

Background: Patients diagnosed with metastatic breast cancer have poor outcome with a median survival of approximately 2 years. While novel therapeutic options are urgently needed, the great majority of breast cancer research has focused on the primary tumor and less is known about metastatic breast cancer and the prognostic impact of the metastatic tumor microenvironment. Here we investigate the

When the impossible becomes possible : COVID-19’s impact on work and travel patterns in Swedish public agencies

Background: The COVID-19 pandemic has rapidly led to some of the most revolutionary changes in private and professional life around the world. While the extent and duration of these changes are not certain, they have already had a great impact on travel patterns. This is also the case in Sweden, despite its relatively liberal approach to restrictions, which relies on voluntary measures such as soc

Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarised 129Xe diffusion-weighted lung MRI

Enlargements of distal airspaces can indicate pathological changes in the lung, but accessible and precise techniques able to measure these regions are lacking. Airspace Dimension Assessment with inhaled nanoparticles (AiDA) is a new method developed for in vivo measurement of distal airspace dimensions. The aim of this study was to benchmark the AiDA method against quantitative measurements of di

Herbivores reduce seedling recruitment in alpine plant communities

Through changes in climate and other environmental factors, alpine tundra ecosystems are subject to increased cover of erect shrubs, reduced predictability of rodent dynamics and changes in wild and domesticated herbivore densities. To predict the dynamics of these ecosystems, we need to understand how these simultaneous changes affect alpine vegetation. In the long term, vegetation dynamics may d

Low-, medium-, and high-spin states in the N=Z+1 nucleus 63Ga

The fusion-evaporation reaction 28Si+40Ca at 122 MeV beam energy was used to populate excited states in the N=Z+1 nucleus 63Ga. With the combination of the Gammasphere spectrometer and the Microball CsI(Tl) charged-particle detector array, the level scheme of 63Ga was extended by more than a factor of two in terms of number of γ-ray transitions and excited states, excitation energy (Ex>30 MeV), an

Intrauterine vertical SARS-CoV-2 infection : a case confirming transplacental transmission followed by divergence of the viral genome

A 27-year-old woman (gravida 2, para 1) was transported to the regional university hospital in gestational week (GW) 34 + 4 due to a three-day history of fever, abdominal pain and reduced foetal movements. She had developed a dry cough one day prior to the admission (Figure S1). The woman, was slightly overweight (BMI 27 kg/m2 ) but otherwise healthy. She had normal antenatal check-ups and an obst

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Joyful Celestials. Jain Murals of Ellora

This article is the outcome of two research trips to the Jain caves at Ellora, the purpose of which was to photograph the best preserved murals found there, works of art that were largely undocumented in any available literature. The article documents and portrays the best preserved paintings in detail found on the walls and ceiling of one of the smaller caves belonging to the largest Jain cave coThis article is the outcome of two research trips to the Jain caves at Ellora, the purpose of which was to photograph the best preserved murals found there, works of art that were largely undocumented in any available literature. The article documents and portrays the best preserved paintings in detail found on the walls and ceiling of one of the smaller caves belonging to the largest Jain cave co

Swedish predicative oblique case : default or not?

This article describes and discusses an ongoing change of case marking, NOM(inative) > OBL(ique), in certain predicates in Swedish (type “Then you can be I” > “Then you can be me”). This change has gone largely unnoticed hitherto. The discussion is based on a large-scale online survey, conducted in May 2016. It was tested whether the change relates to finiteness or to semantics. The results strong