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Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurposing is a promising strategy. Here, we used two independent in silico prediction tools including machine
This essay demonstrates that the origin of modern Russian national conservatism lies in the Soviet underground anti-communist and anti-liberal movement, which developed under the strong influence of the theorists of integral traditionalism, fascism, and the Nouvelle Droite. Vladimir Putin's political ontology, based on the idea of the tragedy of Russia and Europe caused by the weakening of their s
Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappro
This experimental study explored how adopting a deceptive stance affects linguistic processes during real-time production of multi-sentence texts in speaking and writing. Language production involves planning, monitoring and editing – processes that give rise to and are shaped by fluctuations in processing demands. Deception is assumed to influence these processes as speakers and writers manage co
The thesis explores the migration experiences of Syrian refugees who arrived in Sweden and Denmark by crossing the Mediterranean Sea in small, precarious boats. It aims to illuminate how these refugees managed the risks they faced during their journey to Europe and the meanings they associated with these risks. The research focuses on the socio-cultural and individual contexts within which risk is
Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC). To explore the ability of GPACs to induce monocyte activation, we compared two GPAC species, Parvimonas micra and Peptoniphilus harei, with E. coli, a major cause of bloodstream infections. We stimulated w
Background and Aim: Central venous catheters are vital in the peri- and postoperative period for patients undergoing abdominal surgery but are associated with risks such as catheter related infections. Signs of infection, like tenderness and induration at the insertion site, are important to recognize, as they may precede catheter-related infections, but are often neglected. The aim was to compare
A carbon starvation-responding lac fusion of the marine Vibrio sp. strain S14 was used as a reporter strain in order to identify genes critical in the regulation of the carbon starvation response. Interestingly, sequence data together with an altered phenotype with respect to the accumulation of guanosine 3',5'-bispyrophosphate (ppGpp) imply that one of the genes (csrS) identified by this approach
The physiological status of carbon-starved cells of the marine Vibrio sp. strain S14 has been investigated by the analysis of their immediate response to carbon and energy sources. During the first minute after glucose addition to 48-h-starved cells, the pools of ATP and GTP increased rapidly, and the [ATP]/[ADP] ratio reached the level typical for growing cells within 4 min. The total rates of RN
In order to evaluate the role of the stringent response in starvation adaptations of the marine Vibrio sp. strain S14, we have cloned the relA gene and generated relaxed mutants of this organism. The Vibrio relA gene was selected from a chromosomal DNA library by complementation of an Escherichia coli ΔrelA strain. The nucleotide sequence contains a 743-codon open reading frame that encodes a poly
Carbon starvation induces the development of a starvation- and stress- resistant cell state in marine Vibrio sp. strain S14 (CCUG 15956). The starved cells remain highly responsive to nutrients during prolonged starvation and exhibit instantaneous severalfold increases in the rates of protein synthesis and RNA synthesis when substrate is added. In order to elucidate the physiological basis for the
The response of marine Vibrio sp. strain S14 (CCUG 15956) to long-term (48-h) multiple-nutrient starvation (i.e., starvation for glucose, amino acids, ammonium, and phosphate simultaneously) can be described as a three-phase process. The first phase, defined as the stringent control phase, encompasses an accumulation of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and decreases in RNA and prote
