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Single-cell population genetics and dispersal limitation of a bloom-forming microalga

Microalgal range expansions are increasing in frequency and magnitude worldwide mostly due to anthropogenic factors. However, they often remain unnoticed until mass development (algal blooms) occurs due to difficulties in detection when population densities are low. However, population genetic methods offer an approach to investigate these patterns. One such potentially expanding bloom-forming spe

High-resolution global population projections dataset developed with CMIP6 RCP and SSP scenarios for year 2010–2100

We present a novel, global 30 arc seconds (∼1 km at the equator) population projection dataset covering each year from 2010 to 2100 that is consistent with both country level population and gridded urban fractions from the Coupled Model Intercomparison Project 6 (CMIP6). While IPCC population projections until 2100 are available at country level for Socio-Economic Pathways (SSPs), land cover (incl

Associations between long-term exposure to low-level air pollution and risk of chronic kidney disease—findings from the Malmö Diet and Cancer cohort

Background: Associations between air pollution and chronic kidney disease (CKD) have been reported, but studies at low exposure levels and relevant exposure time windows are still warranted. This study investigated clinical CKD at low air pollution levels in the Swedish Malmö Diet and Cancer Cohort in different exposure time windows. Methods: This study included 30,396 individuals, aged 45–74 at e

Atrial Fibrillatory Rate Characterization Extracted from Implanted Cardiac Monitor Data

The aim of this study is to characterize atrial fibrillatory rate (AFR) extracted from a cohort of continuously monitored atrial fibrillation (AF) patients as function of episode duration and onset time. The f-wave signal used to compute the AFR was extracted from a single lead ECG strip of the AF episodes stored in an Implantable Cardiac Monitor (ICM) in a cohort of 99 patients. The f-wave signal

Non-Invasive Characterization of Atrio-Ventricular Properties during Atrial Fibrillation

The atrio-ventricular (AV) node is the primary regulator of ventricular rhythm during atrial fibrillation (AF). Hence, ECG based characterization of AV node properties can be an important tool for monitoring and predicting the effect of rate control drugs. In this work we present a network model of the AV node, and an associated workflow for robust estimation of the model parameters from ECG. The

Changes in RR Series Characteristics during Atrial Fibrillation : An AV Node Simulation Study

The atrioventricular node (AVN) plays an important role in rate control during atrial fibrillation (AF). To further our understanding of the AVN function in AF, we present a model-based study, relating AVN electrophysiological characteristics to changes in RR series characteristics observed during treatment with rate control drugs. The dual-pathway physiology of the AVN was modelled using a networ

Dacarbazine-vindesine versus dacarbazine-vindesine-cisplatin in disseminated malignant melanoma. A randomised phase III trial

In a multicentre phase III study of disseminated malignant melanoma performed in Sweden and Norway, 326 patients were randomised to receive treatment with the combination dacarbazine [DTIC] (D) and vindesine (V) with or without the addition of cisplatin (P). D was given intravenously (i.v.) at a dose of 250 mg/m2 days 1-5 every 4 weeks and V was given i.v. at a dose of 3.0 mg/m2 day 1 weekly. P wa

Imaging of tissue degeneration in knee osteoarthritis using magnetic resonance and synchrotron radiation

Osteoarthritis (OA) is a very common disease, especially in the knee. It is characterized by the breakdown of articular cartilage but involves all parts of the joint. OA is usually diagnosed at a late stage when the articular cartilage has begun to disappear. What happens before these macroscopic alterations is to alarge extent unknown. In this thesis the focus is on articular cartilage and menisc

Structural Changes in Monolayer Cobalt Oxides under Ambient Pressure CO and O2 Studied by In Situ Grazing-Incidence X-ray Absorption Fine Structure Spectroscopy

We have used grazing incidence X-ray absorption fine structure spectroscopy at the cobalt K-edge to characterize monolayer CoO films on Pt(111) under ambient pressure exposure to CO and O2, with the aim of identifying the Co phases present and their transformations under oxidizing and reducing conditions. X-ray absorption near edge structure (XANES) spectra show clear changes in the chemical state

Localized Internationalism : Camping Across Borders in the Early Swedish Boy Scout Movement

This article examines early Boy Scout camps as events of national display and localized internationalism. By detailing how the camp culture of the Swedish Boy Scout movement facilitated transnational integration, the article shows that internationalism as localized practice can be observed in summer camp environments from the early days of the twentieth century. Reports from these early camps high

Tendencies towards integration and disintegration of the entrepreneurial ecosystem: an institution-based view of the dynamics

This empirical study adopts an institutional theory framework to analyze the interactions and complex dynamics of entrepreneurial ecosystems. While previous research investigated interactions between the different actors of the entrepreneurship ecosystem, little attention has been dedicated to understanding the impact of the interactions upon the ecosystem dynamics. Adopting a case study approach

COVID-19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries

Introduction: Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and healthcare systems. Material and methods: This study examines pregnant women with COVID-19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between 1 March and 30 June 2020 an

Bumetanide for autism : Open-label trial in six children

Aim: Bumetanide, a diuretic agent, that reduces intracellular chloride—thereby reinforcing GABAergic inhibition—has been reported to improve core symptoms of autism in children. Given the positive results reported from French trials of bumetanide in children with autism, we decided to evaluate its effects in a small-scale pilot study, in advance of a larger randomised controlled study (RCT). Metho

Cognitive profiles of extremely preterm children : Full-Scale IQ hides strengths and weaknesses

Aim: To study whether a specific cognitive profile can be identified for children born extremely preterm (EPT) by investigating: 1) strengths and weaknesses not revealed by Full-Scale IQ, 2) overlap between different cognitive deficits and 3) proportion of EPT children with multiple deficits. Methods: We analysed data from the 4th version of Wechsler Intelligence Scales for Children in EPT childre