Obesity is a well-established risk factor for colorectal cancer (CRC), but the association with the tumor microenvironment has been sparsely described. Herein, we examined the relationship between pre-diagnostic anthropometry and CRC risk according to tumor immune cell composition, with particular reference to potential sex differences. The density of different immune cell subsets was assessed by

During the last decades of the twentieth century, Western philosophy saw a renewed interest in religion. This ‘turn to religion’ was in many ways prompted by concrete geopolitical developments, such as the surge of religious fundamentalism or the new visibility of religious expressions and symbols in societies that had long conceived of themselves as profoundly secular. At about the same time, a g

Transcription factor (TF)-based reprogramming of somatic tissues holds great promise for regenerative medicine. Previously, we demonstrated that the TFs GATA2, GFI1B, and FOS convert mouse and human fibroblasts to hemogenic endothelial-like precursors that generate hematopoietic stem progenitor (HSPC)-like cells over time. This conversion is lacking in robustness both in yield and biological funct

We report on aryl ether-free 2,7-diphenylfluorene-based copolymers tethered with quinuclidinium (Qui) cations via hexyl spacers, prepared through superacid catalyzed Friedel Crafts polycondensation and quaternization reactions. The 2,7-diphenylfluorene monomers were prepared by Suzuki coupling and employed to increase polymer backbone stiffness. Corresponding copolymers and anion-exchange membrane

In this article, we propose a novel channel for phenomenological studies of the double-parton scattering (DPS) based upon associated production of charm cc¯ and bottom bb¯ quark pairs in well-separated rapidity intervals in ultraperipheral high-energy proton–nucleus collisions. This process provides direct access to the double-gluon distribution in the proton at small-x and enables one to test the

The sharing economy is an emerging niche for innovation capable of disrupting established socio-technical and economic regimes. Because of this potential to cause radical changes in a wide array of domains, research in multiple disciplines addressing various aspects entailing this phenomenon is proliferating. In this emerging body of literature, the understanding and framing of the sharing economy

An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intratumor heterogeneity (RNA-ITH) has been shown to confound existing expression-based biomarkers across multiple cancer types2–6. Here, we analyze multi-region whole-exome and RNA sequencing

Inclusive J/ψ production is studied in minimum-bias proton-proton collisions at a centre-of-mass energy of s = 5.02 TeV by ALICE at the CERN LHC. The measurement is performed at mid-rapidity (|y| < 0.9) in the dielectron decay channel down to zero transverse momentum pT, using a data sample corresponding to an integrated luminosity of Lint = 19.4 ± 0.4 nb−1. The measured pT-integrated inclusive J/

This paper presents a measurement of ZZ production with the ATLAS detector at the Large Hadron Collider. The measurement is carried out in the final state with two charged leptons and two neutrinos, using data collected during 2015 and 2016 in pp collisions at s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. The integrated cross-sections in the total and fiducial phase spaces ar

We combined x-ray powder diffraction (XRD) and x-ray absorption fine structure spectroscopy (XAFS) to characterize the crystallographic and local atomic structure of nanosized La3+ substituted CoFe2O4 spinel ferrite of composition CoLa0.15Fe1.85O4 synthesized by different synthesis routes: standard ceramic technique, citric acid (citrate) precursor and urea assisted flash auto-combustion process.

Sweden and Japan are developed welfare countries facing serious societal and public health challenges due to demographic ageing. The objective of the present study was to provide a background to environmental challenges in the home, related to demographic ageing. Specific aims were to compare: 1) demography and household composition 2) physical housing stocks 3) indoor accidents and 4) housing ada

Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on R

Pavement data collection is the most expensive and time consuming component of Pavement Management System (PMS). Thus, possible methods of minimizing the need of such data might be critical in reducing pavement condition monitoring costs. Also the ability to relate pavement performance prediction models (frequently roughness based) to hot mix asphalt field performance models (distress based) provi

Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on R

The fact that deep learning based algorithms used for digital pathology tend to overfit to the site of the training data is well-known. Since an algorithm that does not generalize is not very useful, we have in this work studied how different data augmentation techniques can reduce this problem but also how data from different sites can be normalized to each other. For both of these approaches we

Non-invasive characterization of brain structure has been made possible by the introduction of magnetic resonance imaging (MRI). Graph modeling of structural connectivity has been useful, but is often limited to defining nodes as regions from a brain atlas. Here, we propose two methods for encoding structural connectivity in a huge brain graph at the voxel-level resolution (i.e., 850'000 voxels) b

Knowledge of the atomic structure of biomolecules, such as proteins, is paramount to understanding their function and interactions in the human body. For example, knowledge of the atomic structure of a target protein is crucial for developing drugs that bind strongly to it and thus help cure diverse diseases.Macromolecular crystallography is the forefront method for determining the atomic structur