We present a physiologically stable porcine model designed for sequential assessments of pharmacological effects on mean hemispheric cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO2) at sustained normocapnia. The dynamic influence of continuously administered fentanyl (0.040 mg.kg-1.h-1 i.v.), nitrous oxide (70%) and pancuronium (0.30 mg.kg-1.h-1 i.v.) on these variables was

This paper proposes a simple residual-based panel CUSUM test of the null hypothesis of cointegration. The test has a limiting normal distribution that is free of nuisance parameters, it is robust to heteroskedasticity and it allows for mixtures of cointegrated and spurious alternatives. Our Monte Carlo results suggest that the test has small-size distortions and reasonable power. In our empirical

A spin-echo single-shot echo-planar imaging (SS-EPI) technique with a reduced field of view (FOV) in the phase-encoding direction is presented that simultaneously reduces susceptibility effects and motion artifacts in diffusion-weighted (DW) imaging (DWI) of the spinal cord at a high field strength (3T). To minimize aliasing, an outer volume suppression (OVS) sequence was implemented. Effective fa

Twenty-two patients with recurrent dislocation after primary total hip arthroplasty (THA) were compared with 43 randomly selected, stratified THA patients without dislocation with regard to radiographic cup position; body composition of bone, fat, and muscle (lean body mass) as determined by dual-energy x-ray absorptiometry; strength in abduction and adduction; range of motion; balance; and vibrat

The stability of single crystals and monolayers of Mn-12 single molecule magnets under the influence of X-ray radiation and other possibly disruptive influences has been investigated by means of synchrotron radiation. Clear evidence for radiation induced sample degradation was found for both single crystals and monolayers. The comparison with spectra obtained after damaging the molecules by Ar+ sp

A tree t-spanner T of a graph G is a spanning tree of G whose max-stretch is t, i.e., the distance between any two vertices in T is at most t times their distance in G. If G has a tree t-spanner but not a tree (t - 1)-spanner, then G is said to have max-stretch of t. In this paper, we study the Max-Stretch Reduction Problem: for an unweighted graph G = (V, E), find a set of edges not in E original

Dragon is a word oriented stream cipher submitted to the ECRYPT project, it operates on key sizes of 128 and 256 bits. The original idea of the design is to use a nonlinear feedback shift register (NLFSR) and a linear part (counter), combined by a filter function to generate a new state of the NLFSR and produce the keystream. The internal state of the cipher is 1088 bits, i.e., any kinds of TMD at

Methylation is a reversible modification of DNA participating in epigenetic regulation of gene expression. It is now clear that atherosclerosis is associated with aberrant DNA methylation patterns in the vascular tissue and peripheral blood cells, but the origin of this anomaly is poorly understood. Based on evidence that global DNA hypomethylation coexists with hyperhomocysteinemia in advanced hu

The technique of molecular imprinting allows the formation of specific recognition sites in synthetic polymers through the use of templates or imprint molecules. These recognition sites mimic the binding sites of antibodies and other biological receptor molecules. Molecularly imprinted polymers can therefore be used in applications relying on specific molecular binding events. The stability, ease

Natural killer (NK) T lymphocytes are a subpopulation of T lymphocytes regarded as early regulators of immune responses. The majority of NKT cells are restricted by the CD1d molecule. NKT cells have mostly been studied in one single mouse strain, C57BL/6 (B6), because of the absence of NK1.1 in other common mouse strains, and the lack of other reliable surface markers for CD1d-restricted cells. To

In this paper, the marginal or incremental consequences of increased parental participation in a day-care surgery unit are analysed. Information about the parental role and instruction concer treatment caused parents to assume a greater share of their child's postoperative care. This advantages for the involved participants. Children and their parents spent a shorter time at the attributable to nu

Mutations in the CYLD gene cause tumors of hair-follicle keratinocytes. The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation. Here we show that mice lacking Cyld are highly susceptible to chemically induced skin tumors. Cyld-/- tumors and keratinocytes treated with 12-O-tetradecanoylphorbol-13 acetate (TPA) or UV

Three issues characterise the background to the MECCA study: A) Throughout Europe, most patients with severe forms of psychotic disorders are cared for in the community. The challenge now is to make processes in community mental health care more effective. B) There are widespread calls to implement regular outcome measurement in routine settings. This, however, is more likely to happen, if it prov

Anionic graft copolymers were prepared through ring-opening anhydride reactions between poly(ethylene oxide) monomethyl ethers (MPEG) and copolymers of maleic anhydride and styrene (SMA), methyl vinyl ether (MEMA) and ethylene (EMA), respectively. The carboxylic acid groups in the graft copolymers were neutralized with KOH, and films were prepared by solution casting. The materials were characteri

Hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) are two highly allergenic compounds used in the chemical industry. A method was developed for quantification of protein adducts of HHPA and MHHPA in human plasma. The plasma was dialysed and the anhydrides were hydrolysed from the proteins at mild acidic conditions. The released hexahydrophthalic acid (HHP acid) and m