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Reduced aortic wall stress in diabetes mellitus

Objective. Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be all etiologic factor in the formation, gr

Landau level structures and semimetal-semiconductor transition in strained InAs/GaSb quantum wells

Using Burt's envelope function theory and the scattering matrix method, we investigate the hybridized electron-hole Landau levels in strained InAs/GaSb quantum wells sandwiched between wide-gap AlSb barrier layers under electric and a quantizing magnetic fields applied perpendicular to interfaces. At zero magnetic field, in the structures studied here, the lowest electron level in the InAs layer l

Normal coronary flow reserve after arterial switch operation for transposition of the great arteries: an intracoronary Doppler guidewire study.

BACKGROUND: Recent studies performed with positron emission tomography have suggested that coronary flow reserve (CFR) is moderately to severely reduced after the arterial switch operation (ASO). These findings are of great concern but have not been confirmed by other methods. METHODS AND RESULTS: Eleven symptom-free children were studied between 4 and 11 (median 6.0) years after the ASO. Flow vel

A longitudinal cohort study on the prevalence of Helicobacter pylori antibodies in Swedish children and adolescents.

The aim of this study was to monitor the Helicobacter pylori antibody seroprevalence of an asymptomatic cohort between the ages of 4 and 18 y. The H. pylori antibody titres in a longitudinally followed cohort of 168 native Swedish children (born between 1972 and 1974) were established at 4, 8, 12, 16, and 18 y of age. Seventeen children (10.1%) were found positive on at least one occasion when a p

Natural selection on immune responsiveness in blue tits Parus caeruleus

What is the form of natural selection on immune responsiveness? For a population at evolutionary equilibrium, there are two different scenarios. First, it is generally assumed that immune defense has both benefits and costs. If variation in immune responsiveness is due to variation in how individuals trade off these costs and benefits, one would expect immune responsiveness to be subject to stabil

A fibronectin-binding protein from Streptococcus equi binds collagen and modulates cell-mediated collagen gel contraction

The N-terminal fragment (FNZN) of the fibronectin-binding protein FNZ from Streptococcus equi subspecies zooepidemieus was investigated as to effects on murine cell interactions with extracellular matrix proteins, FNZN bound to immobilized fibronectin (FN) and native, but not denatured, collagen type I. FNZN had no effect on primary adhesion of cells from the murine myoblastic C2C12 cell line to i

Ny strategi vid typ 2-diabetes prövas i kliniska studier. Glukagonlik peptid 1 (GLP-1) påverkar sjukdomens grundorsaker

GLP-1 (glukagonlik peptid 1) är ett inkretinhormon som frisätts vid varje måltid. GLP-1 stimulerar insulinsekretionen, hämmar glukagonsekretionen, förlångsammar ventrikeltömningen och ger mättnadskänsla. Sammantaget har GLP-1 en glukossänkande effekt. GLP-1 sänker blodglukos och HbA1c när det ges till patienter med typ 2-diabetes. Risken för hypoglykemi är mycket liten. GLP-1 bryts snabbt och effeA novel therapy for type 2 diabetes is based on the gut hormone, glucagon-like peptide-1 (GLP-1). GLP-1 is released from the gut during a meal intake and stimulates insulin secretion. The hormone also inhibits glucagon secretion, delays gastric emptying and induces satiety. It has been shown to reduce circulating glucose both under fasting conditions and after meal intake in subjects with type 2 d

The Escherichia coli ftsK1 mutation attenuates the induction of sigma(s)-dependent genes upon transition to stationary phase

A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of

Antimicrobial susceptibility pattern of Helicobacter pylori strains isolated from adult dyspeptic patients in Tikur Anbassa University Hospital, Addis Ababa, Ethiopia

Presently, there is no published information on the antimicrobial susceptibility pattern of H. pylori strains in Ethiopia to guide the choice of drug for therapy. Therefore, it is becoming clinically relevant to test the in vitro susceptibility of H. pylori clinical isolates prior to treating patients. Susceptibility testing was performed on 50 clinical H. pylori isolates obtained from adult dyspe

Nattsänkning av temperatur i flerbostadshus

Rapporten redovisar en undersökning av energibesparing vid sänkning av temperaturen nattetid i flerbostadshus. Mätningarna visar att en 4-procentig energibesparing har uppnåtts mot en enligt beräkningar förväntad 11-procentig besparing. Utvärdering i 30 hus på fem orter och ingående i internationellt forskningssamarbete genom IEA.

Dikter av Mahmoud Darwish i översättning.

Mahmoud Darwish's senaste diktsamlingar är skrivna inifrån Palestina 1997 och 2001, den sista sedan den andra intifadan brutit ut. Vi (Henry Diab & Kerstin Eksell) har förvärvat rättigheterna till dem från författaren. Översättningarna här är hämtade från vårt arbetsmaterial.

Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy

Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below the age of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorour

Network protection by single and failure-dependent backup paths - modelling and efficiency comparison

The paper deals with traffic recovery in IP/MPLS network carrying traffic of different priority classes. Two off-line network design problems are presented employing two different recovery mechanisms – single backup path and failure-dependent backup path protection. Also, two routing strategies are studied in this paper. A network design problem with failure-dependent path protection mechanism com

Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study

OBJECTIVE: To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. DESIGN: Multicentre, prospective cohort study. SETTING: Nine European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, United Kingdom). PARTICIPANTS: 74,607 men an

Cellular and Molecular Pathways Governing Hematopoietic Stem Cell Fate

Popular Abstract in Swedish Stamcellsbiologi är ett vetenskapligt, kliniskt och politiskt aktuellt ämne idag. Nuförtiden används blodstamceller för att behandla patienter med blod-cancer, bröstcancer eller andra immun-försvarssjukdomar. Blodstamceller finns i benmärgen och är viktiga för blodbild-ning som pågår kontinuerligt genom hela livet hos en individ. Det finns olika slags mogna celler: rödaHematopoietic Stem Cells (HSCs) have been defined to have abilities of both self-renewal and multi-lineage differen-tiation. The balance between these abilities is rigorously controlled under steady-state status (homeostasis) and when the normal processes of self-renewal and differentiation become deregulated, a disorder of blood system (such as leukemias) can occur. HSCs are enriched in lineage n

Great Britain, the United States, and the Security of the Middle East: The Formation of the Baghdad Pact

Popular Abstract in Swedish Anglo-amerikanska relationer efter andra världskriget bestod både av samarbete och konflikt. Ett exempel på det första var Pentagondiskussionerna 1947 då ett amerikanskt uttalande betonade det generella målet att upprätthålla säkerheten i Mellanöstern genom att stödja de brittiska politiska, ekonomiska och strategiska positionerna i området. Ett exempel på det senare vaAnglo-American post-Second World War relations in the Middle East included cases of close cooperation and conflict. An example of the former was the Pentagon Talks in 1947 when an American statement pointed out the general objective of maintaining the security of the Middle East by retaining the British political, economic, and strategic position in areas supported by the United States. An example

Ny avhandling - ägglavar i västra Nordamerika.

För den som vill ha något att bita finns det många angelägna projekt inom lavsystematiken. Ett släkte som inte har rönt någon större uppmärksamhet de senaste 50 åren är Candelariella, ägglavarna, med sin svårbegripliga arttaxonomi. Nu finns en avhandling som förhoppningsvis kan kasta lite ljus på systematiken inom detta släkte. Martin Westberg, en av våra redaktörer, är författare till denna och s