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Linkage analysis of F-2 crosses has led to identification of large numbers of quantitative trait loci (QTL) for complex diseases, but identification of the underlying genes has been more difficult. Reasons for this could be complications that arise from separation of interacting or neighboring loci. We made a partial advanced intercross (PAI) to characterize and fine-map linkage to collagen-induce

Restenosis is a major problem after balloon angioplasty and stent implantation. The aim of this study is to introduce gadolinium neutron capture brachytherapy (GdNCB) as a suitable modality for treatment of stenosis. The utility of GdNCB in intravascular brachytherapy (IVBT) of stent stenosis is investigated by using the GEANT4 and MCNP4B Monte Carlo radiation transport codes. To study capture rat

PURPOSE: Nitric oxide (NO) and carbon monoxide (CO) have been suggested to relax smooth muscle by activating soluble guanylate cyclase (sGC), binding to the same site of the enzyme. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) (Cayman Co., Malmö, Sweden) increases the catalytic rate of sGC by binding to an allosteric site. We investigated whether YC-1 can modulate the relaxant responses o

In this study, we examined the onset and duration of local analgesic effects of bupivacaine incorporated into biodegradable microcapsules (extended-duration local anesthetic; EDLA) administered as subcutaneous infiltrations in different doses in humans. In 18 volunteers, the skin on the medial calf was infiltrated with 10 mL of EDLA, and the opposite calf was infiltrated with 10 mL of aqueous bupi

I examined the costs of producing and maintaining floral structures in Nigella degenii (Ranunculaceae). To test for such costs, I subjected plants of two populations to flower or perianth removal and then evaluated allocation to subsequently produced flowers, fruits, and seeds. Based on data from a flower removal experiment, the amount of resources allocated to flowers during the staminate and pis

We analyze the propagation of electromagnetic waves in nonlinear, bianisotropic, nondispersive, homogeneous media using simple waves and six-vector formalism. The Maxwell equations are formulated as an eigenvalue problem, whose solutions are equivalent to the characteristic propagation directions. We solve the oblique incidence of plane waves in vacuum on a half space of nonlinear material, and pr

An experimental design was used to determine optimal conditions for refolding of a recombinant thermostable and alkaline active xylanase from Bacillus halodurans in PEG-phosphate two-phase system. The influence of different experimental variables on the enzyme recovery has been evaluated. To build the mathematical model and minimize the number of experiments for the design parameters, response sur

Populärvetenskaplig artikel om missbruket av fribrevsrätter inom den svenska statsförvaltningen 1643-1719.

Evaluation of various methods in clinical practice is often based on interpretations by two or more observers. Such data need to be analysed with correct statistics, or the results and conclusions may be misleading. In this study, the use of measures of agreement for ordinal data in five international nursing journals is reviewed and various methods for measuring agreement are presented and discus

The processes of multiplication of electronic excitations (MEE), connected with the creation of secondary excitons or electron-hole (e-h) pairs by hot conduction electrons, are realized in wide-gap metal halides and oxides. In oxides, secondary e-h pairs can be also formed by 27-40 eV photons due to L 1 VV Auger transitions (with the participation of 2s oxygen holes). The excitation spectra of lum

PURPOSE: To evaluate radiologic findings and clinical data in patients with spontaneous spinal epidural hematoma (SSEH). MATERIALS AND METHODS: Thirteen patients (10 men aged 28-71 years; three women aged 40-65 years) with SSEH from 1986 to 1995 underwent magnetic resonance (MR) imaging; six also underwent spinal angiography. Patients with minor trauma, anticoagulant therapy, increased bleeding te

Serum and urinary concentrations of NCl, the non collagenous globular domain of collagen IV, were used as markers for turnover of basement membranes. NCl levels were studied in membranous glomerulonephritis and diabetic nephropathy. Thirteen patients with membranous glomerulonephritis and 8 insulin-dependent diabetic patients with diabetic nephropathy were compared to 16 apparently healthy control

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The heat transfer from turbulent diffusion flames between vertical walls has been computed for different wall and burner configurations. The buoyancy-modified k- model was used to study the turbulent characteristics of the flow. The flamelet concept, coupled to a prescribed probability density function, was employed to model the nonpremixed combustion process. With the nucleation, surface growth,

The regioselectivity in the Rh catalysed 1,4-hydrosilylation of isoprene was investigated. Variation of solvents and temperature did not significantly affect the isomer distribution between tail-product (I) and head-product (II). The choice of ligands had the greater influence, where Rh-I-based catalysts with the strong electron withdrawing ligand CO favoured production of isomer II, while Rh-I ca

In Sweden the use of wooden boards and sca’boards as binding material was custom until the middle of the 19th century. Sca’boards are found in all kinds of more or less expensive bindings with different covering materials; silk, parchment, leather and paper. During the 19th century they were mainly used in simple and cheap retail bindings destined for the peasantry. In this article the reasons for