Deficient production of anti-viral interferons (IFNs) may be involved in causing viral-induced asthma exacerbations. Hence, drugs inducing lung IFN production would be warranted. Azithromycin may reduce asthma exacerbations but its modus operandi is unknown. Here, we investigated if azithromycin induces IFNβ expression in vitro in rhinovirus-infected bronchial epithelial cells from asthmatic donor

Virtually all animal cells express heparan sulfate proteoglycans on the cell surface and in the extracellular matrix. Syndecans are a major group of transmembrane proteoglycans functioning as receptors that mediate signal transmission from the extracellular microenvironment to the cell. Their heparan sulfate chains, due to their vast structural diversity, interact with a wide array of ligands incl

Introduction: Assay discrepancy in factor VIII activity between the one-stage and the chromogenic assays has been described in approximately one third of patients with non-severe haemophilia A. Whether assay discrepancy may also occur in patients with haemophilia B remains unknown. Aim: This study compared the results from the one-stage and the chromogenic assays in patients with haemophilia B. Me

The use of a graphical system for the programming of industrial robots offers a number of advantages. Graphical systems employ an interface that is much easier to use. The resulting motion trajectories can be simulated and tested for collisions or singular points. Contemporary graphical systems use the geometry of the objects that are to be handled or processed in order to generate robot motion tr

This article adopts an evolutionary framework to the study of industrial resilience. We present a study on European regions and assess the extent to which the capacity of their economies to develop new industrial specializations is affected by the global economic crisis of 2008. We compare levels of industry entry in European regions in the period 2004–2008 and 2008–2012, i.e. before and after a m

Welding robots that use sensors to compensate for variations in their environment pose new requirements for programming systems and for controller architectures. Tracking sensors must be programmed with the geometry of the welds and the motions of the robot. The process monitoring system must be programmed with the required process tolerances and the type of weld. Finally, the controller must be pWelding robots that use sensors to compensate for variations in their environment pose new requirements for programming systems and for controller architectures. Tracking sensors must be programmed with the geometry of the welds and the motions of the robot. The process monitoring system must be programmed with the required process tolerances and the type of weld. Finally, the controller must be p

Approximately 5-10 % of all melanoma patients have close relatives with melanoma. 5-20% of melanoma families have germline mutations in the CDKN2A gene. Swedish CDKN2A mutation carriers have a young median age of onset of melanoma, increased risks of multiple primary melanoma and of tobacco-associated cancers in respiratory and upper digestive tissues, and also worse survival compared to non-carri

Aims: To examine whether genetic influences on the development of alcohol use disorders (AUD) among men during emerging adulthood through mid-adulthood are stable or dynamic. Design: A twin study modeling developmental changes in the genetic and environmental influences on AUD during three age periods (18-25, 26-33 and 33-41) as a Cholesky decomposition. Setting: Sweden. Participants: Swedish male

Computational tools are widely used for ranking and prioritizing variants for characterizing their disease relevance. Since numerous tools have been developed, they have to be properly assessed before being applied. Critical Assessment of Genome Interpretation (CAGI) experiments have significantly contributed toward the assessment of prediction methods for various tasks. Within and outside the CAG

Anaplastic large cell lymphomas (ALCLs) are rare CD30+ peripheral T-cell lymphomas (PTCLs) classified according to the expression of the anaplastic lymphoma kinase (ALK+) protein or not (ALK-). We have analysed the outcome and risk factors for survival in a population-based bi-national cohort of patients with systemic ALK+ ALCL. A total of 122 adult (≥18 years) patients diagnosed with ALK+ ALCL be

Few studies have assessed acute dynamic risk repeatedly among paroled offenders to investigate the relationship between changes in acute dynamic risk and recidivism in crime. The present study investigates whether one-month changes in ten stress-related acute dynamic risk factors, collected through automated telephony while the participants were still in prison and over 30 consecutive days followi