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The effect of alertness and visual attention on optokinetic nystagmus (OKN) and optokinetic after-nystagmus (OKAN) was studied in 20 volunteers. Electroencephalographic (EEG) activity was recorded over the occipital lobe. Exposure to sound and vibration caused a significant increase in the mean slow-phase velocity of OKN, whereas its maximum slow-phase velocity remained unaffected. Vibration tende
Saccadic eye movements provide important information about the neuron system at several levels. In recent years computer analysis of saccades has been adapted for use in clinical work. The most common detection methods do not always function without the user's control and aid. In the present paper a digital filter is described for the detection of saccades. This non-recursive filter unscrambles sa
The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness and vertigo and on caloric and postrotatory nystagmus were evaluated in healthy volunteers. TTS-scopolamine was administered transdermally (delivering approximately 10 micrograms X h-1 scopolamine base) and 100 mg dimenhydrinate orally. Lidocaine and tocainide were administered intravenously (average plasma
Peak velocity of saccade, maximum velocity of smooth pursuit, and peak velocity of slow phase of vestibular and optovestibular nystagmus were measured three times daily on three separate days in 6 healthy subjects in order to estimate the intra-individual variation of the results of oculomotor tests. Analysis of variance revealed that the oculomotor performance of the individual subjects varied sy
The effect of transdermally administered scopolamine (TTS scopolamine) (release rate 5 micrograms/h) and dimenhydrinate (100 mg) was examined on optovestibular nystagmus in 16 volunteers in a randomized double-blind trial. A statistically significant decrease in the optokinetic part of nystagmus was observed during all treatments. Most profound reduction was found during treatment with two TTS sco
The maximum velocity gain of smooth pursuit and optokinetic, vestibular, and optovestibular slow phases was examined in 15 patients with pontine, 10 with medullary, 10 with cerebellar, and 5 with combined cerebello-brain stem disorders. Marked dissociations were observed between smooth pursuit and optokinetic slow phases, especially in medullary disease. A cerebellar deficit enhanced slow phase ve
Utopia – the word is simultaneously evocative of hope and dread. As a concept it is stupendously problematic, and yet despite its alleged passing into irrelevance, utopia still remains a household word. Why is this so?Utopia has been reduced to a category. We place a solution in the category of the utopian or, conversely, the not-utopian. Without fail, discussions involving utopia will eventually
The molecular characterization of recurrent chromosome aberrations in the early 1980s laid the foundation for gene fusion detection in cancer. This approach remained the unrivalled method to identify fusion genes for a quarter of a century and led to the detection of more than 700 neoplasia-associated fusion genes. The advancement of deep sequencing in the mid-2000s revolutionized the search for c
Several recent studies of solar twins in the solar neighbourhood have shown a tight correlation between various elemental abundances and age, in particular [Y/Mg]. If this relation is real and valid for other types of stars as well as elsewhere in the Galaxy, it would provide a very powerful tool to derive ages of stars without the need to resort to determining their masses (evolutionary stage) ve
In recent years, we have witnessed an intensive scholarly discussion about the limitations of traditional inward looking regional innovation strategies. New policy approaches put more emphasis on promoting the external connectedness of regions. However, the institutional preconditions for collaboration across borders have received little attention so far. The aim of this paper is to investigate bo
I denna diakroniska studie undersöker jag vilken skönlitteratur som ingått som kurslitteratur i grundutbildningen i spanska vid Lunds universitet från år 1970 fram till 2015. Den korpus av skönlitterära verk som utgör studieobjekt undersöks utifrån tre antaganden, nämligen att ämnet spanska har en mer samtida än klassisk-kanonisk profil, att kurslitteraturen fram till ungefär 1980 dominerades av lThis diachronic study investigates the works of fiction that were listed in the reading lists for graduate courses in Spanish at Lund University between the years 1970 and 2015. The study focuses on the role of Spanish as a literary gatekeeper and analyzes the literary corpus from three assumptions: that the literature listed has a contemporary profile, rather than a classical-canonical one; that
Background: Secondary hyperparathyroidism increases the risk for fractures. Despite improvement in medical therapy, surgical parathyroidectomy (PTX) often becomes necessary, but its effect on risk of fractures is not clear. Our aim was to study the effect of parathyroidectomy on the risk of hip fractures in patients on dialysis or with a functioning renal graft at time of parathyroidectomy.Design:
Background: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-sign
Purpose: Tyrosine kinase inhibitors (TKIs) have well-characterized immunomodulatory effects on T and NK cells, but the effects on the humoral immunity are less well known. In this project, we studied TKI-induced changes in B cell-mediated immunity. Methods: We collected peripheral blood (PB) and bone marrow (BM) samples from chronic myeloid leukemia (CML) patients before and during first-line imat
Objectives: We wanted to investigate the effects of postoperative pulmonary hypertension (PHpostop: mean pulmonary artery pressure [MPAP] ≥ 25 mmHg), diastolic pressure gradient (DPG), pulmonary vascular resistance (PVR), and repeated hemodynamic measurements on long-term survival after heart transplantation (HT). Design: Eighty-nine patients who underwent HT at Skåne University Hospital in Lund i
Purpose: To present data from an interim analysis of a Phase II trial designed to determine the feasibility, safety, and efficacy of individualising treatment based on renal dosimetry, by giving as many cycles as possible within a maximum renal biologically effective dose (BED). Method: Treatment was given with repeated cycles of 7.4 GBq 177Lu-DOTATATE at 8-12-week intervals. Detailed dosimetry wa
