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A Swedish family with choroideremia and a deletion of the CHM gene has been studied with ophthalmological examination, full-field electro-retinography, and DNA analysis in order to characterize the phenotype of the disease. Although all four patients studied had a complete deletion of the gene, they showed a considerable variability regarding the phenotype, including the electroretinogram tracings
Histone H I conjugated superparamagnetic nanoparticles were assessed for their ability to work as magnetic tracers in conjunction with the relative magnetic permeability metre (MPM-100) for the detection and quantification of DNA (deoxyribonucleic acid). The method employed was based on the electrostatic adsorption of DNA (analyte) to amino group derivatised silica (carrier) and subsequent binding
InP nanowires are fabricated by organo-metallic vapour phase epitaxy and studied via photoluminescence measurements performed on single nanowires, finding evidence of state filling with increasing excitation power density. To increase flexibility in fabrication technology we developed a wet chemical procedure to grow a CdS shell on these wires. In these InP-CdS wires the luminescence efficiency wa
1. A new methodological approach for detailed study of the organization of the cerebellar corticonuclear projection was evaluated in barbiturate-anaesthetized cats. Extracellular field potentials were simultaneously recorded in nucleus interpositus anterior and in the forelimb area of the C3 zone, at the cerebellar surface. On electrical and natural stimulation of the forelimb skin, the evoked pos
We propose a scheme for a complete reconstruction of one- and two-particle orbital quantum states in mesoscopic conductors. The conductor in the transport state continuously emits orbital quantum states. The orbital states are manipulated by electronic beam splitters and detected by measurements of average currents and zero frequency current shot-noise correlators. We show how, by a suitable compl
The aim was to study if neural grafts placed brain infarcts could improve functional recovery. The middle cerebral artery was occluded (MCAO) in 19 spontaneously hypertensive rats. Nine rats were sham operated. Twelve to 16 days after the ischemic insult, 9 of the MCAO rats received transplants of dissociated fetal neocortical tissue (MCAO-T) and 1, 3 and 6 months after transplantation surgery, th
In the first part of this thesis, measurement and registration procedures of occlusal interferences and their inter and intraobserver variability were evaluated. In the second part of this thesis, the short and long-term effect of occlusal adjustment therapy was prospectively assessed in a controlled clinical trial in a selected group of 50 patients with myogeneous craniomandibular disorders (CMD)
This article deals with how Swedish welfare authorities, governmental as well as municipal, performed personal case studies during the period 1940 to 1970. The visits at home are focused, as a mean of the authorities to generate truth of the inquired woman. The home visit was part of a personal case inquiry, perhaps initiated from the authorities to create basic data for decision-making. The examp
The article presents two Matlab-based tools for analysis andsimulation of real-time control systems: Jitterbug andTrueTime.Jitterbug allows the user to compute aquadratic performance criterion for a linear control system undervarious timing conditions. The control system is described using anumber of continuous- and discrete-time linear systems. Astochastic timing model with random delays is used
Several poly (dimethylsiloxanes) (PDMS) copolymers of dimethylsiloxane (DMS) with ethylene or propylene oxide were tested as artificial carriers for the delivery of oxygen to biological systems. Copolymers with a DMS content of 33% or lower enhanced glucose oxidation by 200% in contrast to the 25% increase produced by the same concentration of perfluorodecalin. When 0.05% of the copolymer with 18%
Salivary mucins are known to play important roles in the formation of oral salivary films. The aims of the present study were to investigate the behaviour of salivary mucins at solid surfaces with different wettabilities, as well as the influence of electrolyte on the adsorption behaviour. A pure preparation of human salivary MUC5B was used together with a commercial one of bovine submaxillary muc
BACKGROUND: Insulin resistance was found in some but not in all previous studies of non-diabetic first degree relatives of Type 2 diabetic patients. Small study groups, ethnic differences and/or non-optimal techniques may explain the conflicting results. AIM: To study the impact of a family history of Type 2 diabetes on insulin action in a large group of non-diabetic Europeans using the 'gold stan
The prime objective of this study is to investigate if radioluminescence (RL) from carbon-doped aluminum oxide (Al2O3:C) crystals potentially can be used for absorbed dose-rate measurements during proton radiotherapy. The RL from two separate (2 mg) Al2O3:C crystals attached to optical-fiber cables were recorded during irradiations in water in a 175 MeV clinical proton beam. The RL response for lo
Dispersal is of prime importance for many evolutionary processes and has been studied for decades. The reproductive consequences of dispersal have proven difficult to study, simply because it is difficult to keep track of dispersing individuals. In most previous studies evaluating the fitness effects of dispersal, immigrants at a study locality have been lumped into one category and compared to ph
We report abundance excesses of 1.2 and 2.6 dex, respectively, for vanadium and bromine in the hot, peculiar star 3 Cen A. Abundances for these two odd-Z elements have not been previously reported for this star. Taken with previous work, they strengthen the case of the origin of the abundance peculiarities by diffusion.
