Alloreactive memory T cells are major barriers to transplantation acceptance due to their capacity to accelerate rejection. Here, we investigated the effects of combined treatment with arsenic trioxide (As(2)O(3)) and blocking monoclonal antibodies (mAb) against CD154 and LFA-1 (anti-CD154/LFA-1) on graft survival as well as changes in pathology and immunological responses in mice with adoptively

This paper investigates how hyperspectral reflectance (between 350 and 1800 nm) can be used to infer ecosystem properties for a semi-arid savanna grassland in West Africa using a unique in situ-based multi-angular data set of hemispherical conical reflectance factor (HCRF) measurements. Relationships between seasonal dynamics in hyperspectral HCRF and ecosystem properties (biomass, gross primary p

This study describes an atrial fibrillation (AF) detector whose structure is well-adapted both for detection of subclinical AF episodes and for implementation in a battery-powered device for use in continuous long-term monitoring applications. A key aspect for achieving these two properties is the use of an 8-beat sliding window, which thus is much shorter than the 128-beat window used in most exi

We present a non-incremental approach to structure from motion. Our solution is based on robustly computing global rotations from relative geometries and feeding these into the known-rotation framework to create an initial solution for bundle adjustment. To increase robustness we present a new method for constructing reliable point tracks from pairwise matches. We show that our method can be seen

The use of direct oral anticoagulants (DOACs) in patients undergoing elective direct current (DC) cardioversion of non-acute atrial fibrillation (AF) can potentially shorten the time from initiation of anticoagulation treatment to cardioversion, compared with warfarin. The safety of this strategy needs to be investigated. Data from subgroup analysis from clinical trials with DOAC do not clarify wh

SEM-EDS techniques are used to study minute-sized crystals of HFSE minerals in an evolved batch of fluorine-rich granite. The batch separated due to buoyancy from the bulk magma before fluid separation was reached. Fluorine acted as the main complexing agent in the magma, facilitating the transport of many elements. Enhanced concentrations of elements like Nb, Y, REE, Th and possibly Be gave the g

This study investigates agglomeration effects for classical music production in a wide range of cities for a global sample of composers born between 1750 and 1899. Theory suggests a trade-off between agglomeration economies (peer effects) and diseconomies (peer crowding). I test this hypothesis using historical data on composers and employ a unique instrumental variable - a measure of birth centra

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565

Hepatic fibrosis is considered as a physiological wound-healing response to liver injury. The process involves several factors, such as the hepatocyte growth factor (HGF), which restrain hepatic injury and facilitate the reversibility of the fibrotic reaction in response to an acute insult. Chronic liver injury and sustained inflammation cause progressive fibrosis and, ultimately, organ dysfunctio

The 'trade-off' hypothesis for virulence evolution assumes that between-host transmission rate is a positive and saturating function of pathogen exploitation and virulence, but there are as yet few tests of this assumption, in particular for vector-borne pathogens. Here, I show that the infectivity (probability of transmission) of the tick-borne bacterium Borrelia afzelii from two of its natural r

The aim of this study is to evaluate the prevalence and severity of low back pain (LBP) and the influence of sciatica and neurological deficits in old men.

This pioneering study aimed to investigate social disparities in breast cancer (BC) and ovarian cancer (OC) incidence rates among women across Iran's provinces from 2003 to 2009.

Impaired systemic hormonal activity caused by hypothalamic and pituitary injury may contribute to neuropsychological disturbances and poor quality of life following aneurysmal subarachnoid hemorrhage (SAH). This prospective study was designed to longitudinally evaluate long-term clinical outcome and pituitary function after SAH, using dynamic tests for adrencorticotropic and somatotropic secretory

Budburst models have mainly been developed to capture the processes of individual trees, and vary in their complexity and plant physiological realism. We evaluated how well eleven models capture the variation in budburst of birch and Norway spruce in Germany, Austria, the United Kingdom and Finland. The comparison was based on the models performance in relation to their underlying physiological as

Purpose: This study was intended to evaluate a multi-professional health-promoting and disease-preventive intervention organized as multi-professional senior group meetings, which addressed home-dwelling, independently living, cognitively intact elderly persons (80 +/-), by exploring the participants' experiences of the intervention. Method: The focus group methodology was used to interview a tota

A large number of studies have shown that friends’ smoking behavior is strongly associated with an individual’s own risk for smoking. However, few studies have examined whether other features of social networks, independently or conjointly with friends’ smoking behavior, may influence the risk for smoking. Because it is characterized by the growing importance of friendship networks, the transition

A search for resonant production of high-mass top-quark pairs is performed on 2.05 fb(-1) of proton-proton collisions at root s = 7 TeV collected in 2011 with the ATLAS experiment at the Large Hadron Collider. This analysis of the lepton+jets final state is specifically designed for the particular topology that arises from the decay of highly boosted top quarks. The observed t (t) over bar invaria

The Storo greenstone belt in Godthabsfjord, southern West Greenland consists of juxtaposed rock units of different age and origin, and hosts gold mineralisation that is associated with arsenopyrite along a contact between lithological units and along the axial plane of a large fold core. The age and origin of the gold is debatable, but in this paper, we present new arsenopyrite Re-Os and zircon U-