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Aging is accompanied by progressive physiological declines in body functions. However, the molecular mechanisms of aging remain poorly understood in decapod crustaceans, a diverse group of invertebrates. We investigated age-related differences in the hemolymph proteomes of marbled crayfish using label-free protein quantification (LC-MS/MS), applying a significance threshold of p < 0.05 and a fold

We investigated dynamic changes in nicotinamide adenine dinucleotide (NAD+) metabolism in the human occipital lobe using ultra-high field 31P functional magnetic resonance spectroscopy (fMRS) at 7 T. Twenty-five healthy volunteers (mean age 24 ± 4 years, 10 females) performed a visual task alternating between fixation and flashing checkerboard stimuli. 31P MRS spectra were acquired from a visual c

We derive an explicit link between Gaussian Markov random fields on metric graphs and graphical models, and in particular show that a Markov random field restricted to the vertices of the graph is, under mild regularity conditions, a Gaussian graphical model. This graphical model has a distribution which is faithful to its pairwise independence graph, that coincides with the neighbor structure of

Drawing on a playful notebook entry from Hans Jonas’s student years, this article examines why Jonas consistently sidestepped Friedrich Schelling’s Naturphilosophie in his writings on philosophical biology. It begins by outlining the many affinities between the two thinkers, as noted in previous scholarship: both articulate an asubjective teleology, both understand or­ganisms as self-individuating

Introduction: Irritable bowel syndrome (IBS) has been linked to poor health, high stress and diminished quality of life. Previous findings about associations between IBS and cardiovascular disease are, however, contradictory. Our objective was to examine 10-year cardiovascular risk, lifestyle factors, and self-rated health in people with IBS compared to a reference group. Methods: Sweden's souther

Accessing high-spin configurations of transition metal phosphides defines a dividing line that prevents common properties of solid-state materials from being replicated within multiple-bonded molecular analogs. Here, we report the synthesis of a VIII phosphaethynolate complex, [(pyrNdipp)2V(PCO)] (2) in a halide metathesis with Na(OCP). Exposure of 2 to Lewis-basic ligands induces a one-electron r

The imaging capabilities of an in-house X-ray setup for micro computed tomography, consisting of a photon-counting detector and a liquid target source, are reported here. The effect of the finite X-ray source spot size on the image resolution is measured using the slanted edge method at different sample-to-detector distances, and the energy response of the detector is probed using clinically relev

This study investigates how decision makers at the fire service responds to different types of information and how it can enhance fire service operations during incidents. Semi-structured interviews were conducted with 47 incident commanders from three countries (Sweden, Finland and USA) to assess the influence of pre-planned, real-time, and predictive information on decision-making. The results i

Background The distal forearm fracture is the most common fracture in children. To allocate health care resources and evaluate if prevention strategies have been successful, it is essential to monitor changes in the epidemiology of common fractures. Methods Our hospital serves a city in which year 2006 included 276,244 inhabitants (49,664 <17 years of age). Through the hospital archives, we identi

This report has been prepared with funding from the Nordic Council of Ministers by experts at HEUNI, Fafo and Lund university. The report is a response to a call by the Nordic Work Environment Committee in early 2024 seeking research on the relationship between labour market crime and work environment risks, with the aim of generating more knowledge and practical recommendations and solutions. The

Ultralow-cross-linked microgels serve as powerful model systems for investigating structure–rheology relationships in soft colloidal suspensions. Using precipitation polymerization, we obtain both self-cross-linked microgels with a weakly cross-linked core, surrounded by an ultrasoft corona (ULC), and regular cross-linked (RC) microgels. ULC microgel suspensions exhibit distinctive rheological res

Epigenome-wide studies of pancreatic islets provide valuable insights into type 2 diabetes (T2D) but lack methylomes from individual cell types. Here we show changes to alpha and beta cell-specific methylomes and transcriptomes from people with or without T2D, using whole-genome bisulfite sequencing and RNA sequencing. We discover 22,544 differentially methylated regions annotated to 7,975 genes i

Background: Dementia is a growing public health concern, and although diet is a modifiable potential risk factor, the role of free sugar intake remains unclear. Excess sugar has been linked to metabolic and cardiovascular dysfunction, both associated with cognitive decline, but evidence regarding specific sugar sources is limited. Objectives: This study aimed to investigate the associations betwee