Search results

Temperature, a key environmental stressor, can induce changes at the molecular levels in the body of living beings, which are necessary for adaptation and survival under altered conditions. We investigated the effects of acute cold (3 °C) and heat (32 °C) shocks on hemolymph protein profiles in marbled crayfish. Results showed that cold shock induced a metabolic shift toward glucose production by

INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevention of ischemic stroke. PATIENTS AND METHODS: Oral faCtor Eleven A iNhibitor asundexian as novel ant

In parallel with the exponential increase in extractivism around the world, comes social movements resisting such processes and advocating for alternative forms of development. Extractivism - a mode of accumulation associated with capitalism - is problematic due to the socio-ecological destruction that is embedded in its logics. Opposition to extractivism has intensified and in many instances, wom

Volume 3 of the FCC Feasibility Report presents studies related to civil engineering, the development of a project implementation scenario, and environmental and sustainability aspects. The report details the iterative improvements made to the civil engineering concepts since 2018, taking into account subsurface conditions, accelerator and experiment requirements, and territorial considerations. I

Volume 1 of the FCC Feasibility Report presents an overview of the physics case, experimental programme, and detector concepts for the Future Circular Collider (FCC). This volume outlines how FCC would address some of the most profound open questions in particle physics, from precision studies of the Higgs and EW bosons and of the top quark, to the exploration of physics beyond the Standard Model.

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful risk factors, population growth, and population aging. Objectives: We report estimates of global, national, and subnational CVD burden, including

As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related disease research, the impact of the field on human health now and in the future, and what challenges need to be addressed to ensure sustained progress. © Springer Nature America, Inc. 2026.

Temperature variability and long-term warming are increasingly threatening agricultural sustainability in southern Rwanda, where smallholder farmers rely on climate-sensitive crops. However, comprehensive spatiotemporal assessments of temperature extremes and their impacts on agriculture remain limited. This study used daily minimum and maximum temperature data from 1983 to 2021 for Huye District,

The effect of periodate oxidation and borohydride reduction on arabinoxylan (AX) in aqueous solution was investigated using 13C NMR spectroscopy and small-angle X-ray scattering (SAXS). AX consists of a xylose backbone, which is mono- or di-substituted with arabinose. We show that at a ring-opening modification degree of 21%, periodate oxidation occurs predominantly on arabinose, and shows a prefe

Inverted perovskite solar cells (IPSCs) have emerged as promising photovoltaic technologies due to excellent photoelectric properties and solution processing advantages. However, the traditional preparation process based on inert atmosphere annealing of perovskite films faces key challenges, including high energy consumption, strict crystallization control, and the presence of stresses. The study

Background: Blood cultures (BCs) are key diagnostic elements for sepsis patients. Accurate preanalytical procedures are substantial, and results should be available as soon as possible to guide adequate antimicrobial treatment. This study aimed to evaluate BC collection practices and diagnostic capacity across European hospitals. Methods: This cross-sectional survey investigated BC diagnostics in

This paper examines the influence of the Efficient Markets Hypothesis (EMH) on financial regulation, using a perspective drawing on arguments from the Philosophy of Science discipline.The paper aims to show that, prior to the global financial crisis, there already existed a large body of empirically observed asset price anomalies, which may be seen to contradict the notion of elastic demand curves

Efficient and clean production of electrical and mechanical energy for use in industry, transportation and propulsion is currently a concern. The transition from fossil fuels to biofuels involves challenges related to the fuel composition and combustion, as well as methods to increase engine fuel flexibility. One potentially useful tool under development is Plasma Assisted Combustion (PAC), where

Background Advances in medical and surgical care have improved survival in patients with transposition of the great arteries (TGA), shifting focus toward quality of life (QoL). In this study we evaluate QoL in adults with TGA, including congenitally corrected TGA (ccTGA) and patients with dextro-TGA (d-TGA), by comparing patients with a systemic right ventricle (sRV) and systemic left ventricle (s

This paper studies whether central bank collateral frameworks play a stabilising role during large redemption shocks to investment funds. Using the “dash-for-cash” of 2020 as a case study, we find that funds with a higher share of ECB-eligible corporate bonds experienced lower redemption volumes, especially those with close affiliation to banks. We also find that asset managers followed a liquidat

Renewable diesel fuels may reduce greenhouse gas emissions and particulate matter compared to fossil diesel, but the toxicity of their combustion products remains unclear. This study assessed pulmonary effects of renewable diesel exhaust particles in female C57BL/6NTac mice after single intratracheal instillation (6, 18, or 54 µg/mouse). Particles were generated from renewable fuels (rapeseed meth

Like many cities worldwide, Amsterdam has ambitious plans around sustainability transitions. The city has oriented towards an alternative economic development model called “Doughnut Economics” and has attempted to implement ideas from the work of economist Kate Raworth on the ground through a “Doughnut Strategy” and the Amsterdam Doughnut Coalition. This paper explores the evolution of Amsterdam's

Introduction: Turnover rates among health-care personnel are rising, which could jeopardise patient safety and the quality of care. One contributing factor to the high turnover is the prevalence of mental distress. Stress of conscience among healthcare personnel has been shown to affect them negatively, and feeling that they cannot provide the care their patients need increases their stress levels

Abstract – Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of na

Context. Super-Earths and mini-Neptunes are missing from our Solar System, yet they appear to be the most abundant planetary types in our Galaxy. A detailed characterization of key planets within this population is important for understanding the formation mechanisms of rocky and gas giant planets and the diversity of planetary interior structures. Aims. In 2019, NASA’s TESS satellite found a tran