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Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, and heme- and radical-binding properties. We studied matched knee synovial fluid
Background: Children born very preterm (PT) after fetal growth restriction (FGR) exhibit cognitive impairment at early school age. The relationship between neurodevelopmental impairment and attained regional brain volumes is unknown. Methods: We studied 23 preterm children with FGR (PT-FGR), 24 matched preterm children AGA (PT-AGA), and 27 matched term AGA children (T-AGA) by measuring brain volum
Powder materials containing copper ions supported on ZSM-5 (Cu-Zeolite Socony Mobil-5) and SSZ-13 (Cu-Standard Oil synthesised zeolite-13), and predominantly CuO nanoparticles on amorphous SiO2 were synthesised, characterised, wash-coated onto ceramic monoliths and, for the first time, compared as catalysts for direct conversion of methane to methanol (DCMM) at ambient pressure (1 atm) using O2, N
We measured direct photons for pT<5GeV/c in minimum bias and 0%–40% most-central events at midrapidity for Cu+Cu collisions at √sNN=200GeV. The e+e− contribution from quasireal direct virtual photons has been determined as an excess over the known hadronic contributions in the e+e− mass distribution. A clear enhancement of photons over the binary scaled p+p fit is observed for pT<4GeV/c in Cu+Cu d
Human carbonic anhydrase IX (CA IX) is a multi-domain membrane protein that is therefore difficult to express or crystalize. To prepare crystals that are suitable for neutron studies, we are using only the catalytic domain of CA IX with six surface mutations, named surface variant (SV). The crystallization of CA IX SV, and also partly deuterated CA IX SV, was enabled by the use of microseed matrix
Stricter building regulations have resulted in the construction of buildings with a low energy use during the operation phase. It has now become increasingly important to also look at the embodied energy, because it might, over the lifespan of the building, equal the energy used for operating the building. One way to decrease the embodied energy is to reuse building materials and components or to
Aims: Chronic left atrial enlargement (LAE) increases the risk of atrial fibrillation. Electrocardiogram (ECG) criteria might provide a means to diagnose LAE and identify patients at risk; however, current criteria perform poorly. We seek to characterize the potentially differential effects of atrial dilation vs. hypertrophy on the ECG P-wave. Methods and results: We predict effects on the P-wave
This paper presents a procedure to derive a thermal lumped-parameter grey-box model of an electric machine built for traction. The procedure includes experimental data logged under overload conditions for accurate temperature prediction at high currents, and features a relatively simple loss estimation approach. Validation of the model shows a good fit between measured and simulated results. Possi
This article presents a concept of direct cooled windings for electrical machines, pumping air through hollow rectangular copper windings. The thermal constraints pose a serious limitation in the performance of many applications of electrical machines, not least in electrical vehicles. The difference between temporary maximum output and continuous output is often substantial. This difference can b
This paper explores and assesses power loss generation and heat extraction in a stator with directly air-cooled laminated winding. An electrical machine winding made of an electric conducting sheet, which have slotted structure for accommodating a magnetic core, is denoted a laminated winding. A space is introduced between the conducting sheets so that the heating power is removed right where it i
This paper presents and assesses the cooling integration of electrical machines with concentrated windings. A conventional coil in a concentrated winding with forced cooling applied on the exterior coil surfaces is replaced by an alternative solution where the coil is opened up in a laminar structure with the intention of the coolant fluid penetrating the coil and removing the interior heat. This
This paper explores the urban form, demographic and socio-economic dependencies of walking, cycling and e-biking in Beijing based on a survey (N = 1427) of daily travel among residents in eight neighborhoods, enriched with urban form variables. The results show that walking is most frequently used, followed by cycling, which in turn is more frequent than e-biking. Walking and cycling are preferred
The ISO 22400 has defined a set of Key Performance Indicators (KPIs) to evaluate the performance of manufacturing operation. Though the calculation formulas and tendency analysis of KPIs are given in the standard, it is important to evaluate how the standard performs when implemented in an industrial setting. Based on analyzing the production process in Volvo car, an aggregation KPI evaluation sys
Cities around the world are constructing bicycle infrastructure to increase cycling. However, identifying efficient design solutions and determining how bicycle infrastructure planning knowledge can be integrated into comprehensive policy remains a challenge. The objective of this paper is to shed light on the strengths and weaknesses of current bicycle infrastructure planning in both an experienc
University teachers’ engagement in teaching is a crucial aspect for the quality of student learning. In this article, we explore where such engagement comes from. We use a sociocultural perspective to investigate how teachers’ colleagues and leaders, in what we call academic microcultures, influence such engagement. A microculture can be a working group such as a teaching team, an educational progUniversity teachers’ engagement in teaching is a crucial aspect for the quality of student learning. In this article, we explore where such engagement comes from. We use a sociocultural perspective to investigate how teachers’ colleagues and leaders, in what we call academic microcultures, influence such engagement. A microculture can be a working group such as a teaching team, an educational prog
Controlled experiments on software variants enable e-commerce companies to increase sales by providing user-adapted functionality. Our goal is to understand how the context of experimentation influences tool support. We performed a case study at Apptus that develops algorithms for e-commerce. We investigated how the case company uses experiments through five semi-structured interviews. We identifi
