Popular Abstract in Swedish Personer med insulinbehandlad diabetes saknar, eller har kraftigt försämrad, kroppsegen förmåga att reglera blodsockernivån genom utsöndring av hormonet insulin, och måste därför ta flera injektioner insulin dagligen. De flesta injektioner tas i samband med måltid, och individen bestämmer normalt sina måltidsdoser utifrån aktuell blodsocker- och hälsostatus i kombinatioDiabetes is a disease characterized by insufficient capacity to regulate the blood glucose level. In insulin-dependent diabetes, multiple daily injections of insulin have to be administered. In-between scheduled visits to the care provider, the patient has to manage the glucose control independently. Insulin dosing is a non-trivial task and many patients find it difficult. This is reflected in the

The aim of this article was to present juxtavisceral aortic occlusive disease with particular reference to a novel therapeutic approach, namely protected stenting by means of so called chimney grafts. The juxta renal aortic occlusion is the last aortoiliac occlusive lesion not to be stented routinely because of the risk for trash and/or need for overstenting of vital aortic side branches. The risk

Recently, the anticancer activity of human a-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive native bovine alpha-lactalbumin (BLA) protein. In this study, atomic force microscopy resolved membrane distortions and annular oligomers (AOs) produced by HAMLET when deposited

Dendrochronological analysis was applied to subfossil remains of Scots pine (Pinus sylvestris L.) buried in a South Swedish peat deposit. In combination with peat stratigraphy, this approach was explored for its potential to provide information on the local hydrological and depositional history at the site, forming the basis for a regional palaeohydrological analysis. A 726-year ring-width chronol

We explore the emergence of two contemporary mega water projects in Turkey that are designed to meet the demands of the country's major urban centers. Moreover, we analyze how policy makers in the water sector frame problems and solutions. We argue that these projects represent a tendency to depoliticize water management and steer away from controversial issues of water allocation by emphasizing l

Our existing urban environment has a significant potential to increase the use of renewable energy, mainly by using solar irradiation for heat and electricity. Quantification of the solar potential by means of a solar map is the first step in the acceleration process for using more solar energy in our urban environments. A solar map is a GIS system providing the annual solar irradiation on buildin

Background: The next-to-next-to-next-to-leading order ((NLO)-L-3) nuclear energy density functional extends the standard Skyrme functional with new terms depending on higher-order derivatives of densities, introduced to gain better precision in the nuclear many-body calculations. A thorough study of the transformation properties of the functional with respect to different symmetries is required as

Bisphosphonates (BP) prevent, reduce, and delay cancer-related skeletal complications in patients, and have substantially decreased the prevalence of such events since their introduction. Today, a broad range of BP with differences in potency, efficacy, dosing, and administration as well as approved indications is available. In addition, results of clinical trials investigating the efficacy of BP

In order to increase the understanding of suicidal behaviour, the general aim of the thesis is to gain a profound knowledge of the suicidal individual, and hence to find and ensure a preventive strategy. This will be accomplished by finding and trying new methods for evaluation of suicide risk. The Suicide Assessments Scale, SUAS, and a new self-rating version, SUAS-S were tested. These scales ar

Vid direkt anföring uppvisar såväl anföringssats som anförd sats huvudsats¬egenskaper och det är inte uppenbart hur förhållandet mellan satserna i en anförd mening ska förstås. I denna uppsats undersöks det hierarkiska förhållandet mellan anföringssats och an¬förd sats ur såväl semantisk/pragmatisk som syntaktisk synvinkel. Undersökningens utgångs¬punkt är tre antaganden om huvud- och bisatser: 1)

Introduction A recent genome-wide association study in European systemic sclerosis (SSc) patients identified three loci (PSORS1C1, TNIP1 and RHOB) as novel genetic risk factors for the disease. The aim of this study was to replicate the previously mentioned findings in a large multicentre independent SSc cohort of Caucasian ancestry. Methods 4389 SSc patients and 7611 healthy controls from differe

Studies on beta cell metabolism are often conducted in rodent beta cell lines due to the lack of stable human beta cell lines. Recently, a human cell line, EndoC-βH1, was generated. Here we investigate stimulus-secretion coupling in this cell line, and compare it with that in the rat beta cell line, INS-1 832/13, and human islets.

The learning parity with noise (LPN) problem has recently proved to be of great importance in cryptology. A special and very useful case is the Ring-LPN problem, which typically provides improved efficiency in the constructed cryptographic primitive. We present a new algorithm for solving the Ring-LPN problem in the case when the polynomial used is reducible. It greatly outperforms the previous al

BACKGROUND: Certain immune-mediated diseases (IMDs), such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to cardiovascular disorders. We examined whether there is an association between 32 different IMDs and risk of subsequent hospitalization for coronary heart disease (CHD) related to coronary atherosclerosis in a nationwide follow up study in Sweden. METHODS AND FIND

Obese and/or diabetic patients have elevated levels of free fatty acids and increased susceptibility to gastrointestinal symptoms. Since the enteric nervous system is pivotal in regulating gastrointestinal functions alterations or neuropathy in the enteric neurons are suspected to occur in these conditions. Lipid induced intestinal changes, in particular on enteric neurons, were investigated in vi

ApolipoproteinA-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis. During reverse cholesterol transport, HDL transitions between an array of subclasses, differing in size and composition. This process requires ApoA-I to adapt to changes in the shape of the HDL particle, transiting from an apolipoprotein to a myri