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Laminin-211 is a major constituent of the skeletal muscle basement membrane, exerting its biological functions by binding to cell surface receptors integrin α7β1 and dystroglycan (the latter is part of the dystrophin-glycoprotein complex). The importance of these molecules for normal muscle function is underscored by the fact that their respective deficiency leads to different forms of muscular dy

Objective To compare the experience and attitude of obstetricians in Europe towards late termination of pregnancy and the factors affecting their responses. Design Cluster sampling cross-sectional survey. All neonatal intensive care unit (NICU)-associated maternity units were recruited (census sampling) in Luxembourg, the Netherlands and Sweden. In France, Germany, Italy, Spain and the UK, units w

Background: Empowerment is essential for gender equity and health. The city of Malmö, Sweden, has formulated a development plan for gender equity integration (GEIDP). A 'Policy Empowerment Index' (PEI) was previously developed to assess the empowerment potential of policies. Objectives: To pilot-evaluate the GEIDP's potential for empowerment and to test the PEI for future policy evaluations. Desig

Despite advances in anti-platelet treatments, there still exists an early increase in both ischemic as well as bleeding events following primary PCI in patients with ST-elevation myocardial infarction (STEMI). Platelet inhibition data of different anti-platelet treatments in the acute phase of a myocardial infarction might offer some insight into these problems. The aim of this study was to evalua

Due to the recent interest in enzymatic biofuel cells (BECs), sugar oxidizing enzymes other than the commonly used glucose oxidase are gaining more importance as possible bioelements of implantable microscale-devices, which can, for example, be used in biosensors and pacemakers. In this study we used rational and semi-rational protein design to improve the catalytic activity of the enzyme pyranose

In untreated patients with Alzheimer disease (AD) the functional ability is gradually lost. What happens to the patients after continuous long-term cholinesterase inhibitor (ChEI) treatment is less investigated. The objective of this study was to describe the longitudinal functional outcome and analyze factors affecting the outcome in ChEI-treated patients. In an open, 3-year, nonrandomized, prosp

The Price of Democracy and the Value of Literature : Books, Politics, and the Literary Market with Respect to the 2002 Reduction in VAT on Books in Sweden In 2002 the VAT (value added tax) on books in Sweden was reduced from 25% to 6 %. The reduction was effected in response to a cultural policy, whose aim was to ”improve the conditions for literature and reading” and ”stimulate a diversifed out

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases affecting photoreceptors and causing blindness in humans. Previously, excessive activation of enzymes belonging to the poly-ADP-ribose polymerase (PARP) group was shown to be involved in photoreceptor degeneration in the human homologous rd1 mouse model for RP. Since there are at least 16 different PARP isoforms, we inves

Feminisation of the HIV/AIDS epidemic in sub-Saharan Africa is an important public health concern. Therefore, it is crucial that we understand the various risk factors that shape unsafe sexual behaviours among young people in Uganda. The overall aim of this thesis was to gain a deeper understanding of the various factors that have an association with risky sexual behaviours among Ugandan universit

NGC 2419 is a peculiar Galactic globular cluster off set from the others in the size-luminosity diagram, and showing several chemical abundance anomalies. Here, we present Stromgren uvby photometry of the cluster. Using the gravity-and metallicity-sensitive c(1) and m(1) indices, we identify a sample of likely cluster members extending well beyond the formal tidal radius. The estimated contaminati

Context: To treat or not to treat is one of the most difficult dilemmas facing prostate cancer patients, especially elderly men with early prostate cancer or small cancer that is contained within the prostate. Objective: The primary objective of this review is to analyse the treatment options for patients with localised prostate cancer. This information can be considered alongside other important

Popular Abstract in Swedish I vår egen tid finns ett stort intresse för släktforskning och historia hos många. Men man tänker sällan på att även människor i gångna tider kunnat blicka tillbaka på sitt förflutna och fundera på sin egen plats i släktleden. Vad var de ville minnas och hur mindes de i en tid utan skriv- och läskunnighet? Det är frågor som ställs i avhandlingen och där svaren söks i deThis thesis examine how farm-dwellers in the Mälaren region during the late Iron Age and early Middle Ages created, transferred, and preserved memory by deliberately placing new houses and graves on the houses and graves of previous generations. Focus is on memory as a social phenomenon and culture-specific resource created by these deliberate practices. The culture-specific element is oral cultur

By virtue of their undisputed role in allergy, the study of airway mast cells has focused on nasal and bronchial mast cells and their involvement in allergic rhinitis and asthma. However, recent mechanistic and human studies suggest that peripheral mast cells also have an important role in asthma, as well as chronic obstructive pulmonary disease, respiratory infections and lung fibrosis. Pathogeni

Land development usually induces large changes in flood peak and infiltration properties, thus affecting the entire hydrological environment of the area. In order to evaluate such negative effects caused by land-use change, it is necessary to estimate the changes in surface runoff and groundwater recharge rate. The effects of land-use changes on the parameter values of a groundwater recharge model