Pancreatic cancer is a devastating disease with a dismal prognosis. Despite profound medical advances in systemic therapies for other types of aggressive tumours during recent years, a diagnosis of pancreatic cancer is still often synonymous with a fatal outcome. The term periampullary cancer includes pancreatic cancer and applies to the group of tumours found in proximity to the ampulla of Vater.

https://www.lupop.lu.se/article/chemotherapy-host-response-and-molecular-dynamics-periampullary-cancer-champ-study - 2025-08-25

The real burden of human cystic echinococcosis (CE) remains elusive, due to the peculiar characteristics of the disease and the heterogeneous and incomplete data recording of clinical cases. Furthermore, official notification systems do not collect pivotal clinical information, which would allow the comparison of different treatment outcomes, and thus circumvent the difficulty of implementing clin

https://www.lupop.lu.se/article/european-register-cystic-echinococcosis-erce-state-art-five-years-after-its-launch - 2025-08-25

Sex offender registries (SORs) were established due to policies and practices intended to protect the public from individuals who commit sexually violent acts, and yet the empirical literature does not show that public SORs reduce or prevent sexual crimes. Given that politicians prominently influence SOR policies, the current study explores the views of SORs by 26 political decision-makers from Ca

https://www.lupop.lu.se/article/sex-offender-registries-exploring-attitudes-and-knowledge-political-decision-makers - 2025-08-25

We evaluated a structured education- and exercise-based self-management program for patients with knee or hip osteoarthritis (OA), using a registry-based study of data from 44,634 patients taken from the Swedish “Better Management of Patients with Osteoarthritis” registry. Outcome measures included a numeric rating scale (NRS), EuroQol five dimension scale (EQ-5D), Arthritis self-efficacy scale (A

https://www.lupop.lu.se/article/better-management-patients-osteoarthritis-program-outcomes-after-evidence-based-education-and - 2025-08-25

High-quality clinical research of resuscitations in a pediatric emergency department is challenging because of the limitations of traditional methods of data collection (chart review, self-report) and the low frequency of cases in a single center. To facilitate valid and reliable research for resuscitations in the pediatric emergency department, investigators from 3 pediatric centers, each with ex

https://www.lupop.lu.se/article/videography-pediatric-emergency-research-establishing-multicenter-collaborative-and-resuscitation - 2025-08-25

International research has found changes in how today’s young people evaluate themselves. The present Swedish research contributes with new findings by distinguishing different patterns of change in self-evaluation in two age groups. The study investigates generational and gender differences in five self-evaluation dimensions in two samples, one from 1983 (N = 3052 10–16-year-old students) and one

https://www.lupop.lu.se/article/self-evaluation-differences-among-swedish-children-and-adolescents-over-30-year-period - 2025-08-25

Pain treatment post orthopaedic care in the elderly is complicated and requires careful follow-up. Current guidelines state all patients prescribed opioids should have a plan for gradual reduction, with the treatment progressively reduced and ended if any pain remains after more than three months. How this works in primary care remains to be explored. The aim was to describe pain treatment and its

https://www.lupop.lu.se/article/descriptive-study-pain-treatment-and-its-follow-primary-care-elderly-patients-after-orthopaedic-care - 2025-08-25

Most participants reported their overall physical and mental health as good (60 [72%] and 50 [60%], respectively) and said they could access medical care (69 [83%]). Fifty (60%) participants had access to food, 72 (87%) had access to basic water, and 55 (66%) lived in housing adequate for their health. Most participants had studied in school (74 [89%]) but only 27 (33%) of the participants were wo

https://www.lupop.lu.se/article/access-basic-needs-and-health-care-malawian-prosthetic-and-orthotic-users-lower-limb-physical - 2025-08-25

Different methods can be used to define healthy vascular ageing (HVA). In this prospective cohort study, we explored three different definitions in order to provide guidance for which to use. 2718 subjects were included from the Cardiovascular (CV) arm of the Malmö Diet Cancer Study (MDCS; median age 71.9 years, 62.2% females). Three different definitions of HVA were used: HVA-1 (<15th percentile

https://www.lupop.lu.se/article/exploring-and-comparing-definitions-healthy-vascular-ageing-population-characteristics-and - 2025-08-25

The present study investigated the potential moderating role of physical activity on the relationship between parental rejection and poor body image perceptions. Late adolescents and young adults from Turkey (N = 373; 256 females/117 males) reported their memories of upbringing (Egna Minnen Beträffande Uppfostran/EMBU) related to both their mother and father, respectively, levels of physical activ

https://www.lupop.lu.se/article/role-physical-activity-parental-rejection-and-body-image-perceptions - 2025-08-25

People with ID who were ≥55years old and alive at the end of 2012 (n = 7936; ID cohort) were identified through a national register of people with ID who received social services in Sweden to optimise the individual's opportunity for good living conditions in daily life. An equally large reference cohort from the general population (gPop cohort) was matched by year of birth and sex. Cancer diagnos

https://www.lupop.lu.se/article/cancer-diagnoses-among-older-people-intellectual-disability-compared-general-population-national - 2025-08-25

Children diagnosed with right ventricle outflow tract (RVOT) anomalies require surgical repair early in life, reoperations and lifelong follow-up. The aim is to comprehensively describe their health related quality of life (HRQoL) and to assess the agreement in this regard between children and parents. New publication in Front. Cardiovasc. Med.

https://www.lupop.lu.se/article/health-related-quality-life-children-earlier-surgical-repair-right-ventricular-outflow-tract - 2025-08-25

Charnley, McKee and Ling, arguably the pioneers of Total Hip Replacement (THR), all recommended that there should be some sort of register for hip replacements. Perceptively, Sir John wrote in 1972: “Serious consideration should be given to establishing a Central Register to keep a finger on the pulse of total implant surgery on a nation-wide basis.” However, it was Peter Herberts and Lennart Ahnf

https://www.lupop.lu.se/article/how-registry-data-can-improve-outcomes-joint-replacement-seminal-paper - 2025-08-25

Women with lower levels of serum selenium (Se) may have a worse survival in breast cancer than women with higher levels, despite no difference in incidence of the disease. Our study was conducted to test whether Se is associated with the aggressiveness of breast tumors. Both the risk of having a tumor characteristic associated with worse prognosis, as well as the overall and breast cancer‐specific

https://www.lupop.lu.se/article/prediagnostic-serum-selenium-levels-relation-breast-cancer-survival-and-tumor-characteristics - 2025-08-25

Patients were significantly better (p < 0.001) than their physicians in estimating the average probability of heart failure compared with actual outcome data (14% vs. 24%, outcome 15%), AMI (16% vs. 26%, outcome 8%), and stroke (15% vs. 25%, outcome 11%). Patients were significantly worse (p < 0.001) at estimating the average probability of death (10% vs. 18%, actual outcome 20%). Neither the pati

https://www.lupop.lu.se/article/do-patients-or-their-physicians-more-accurately-assess-long-term-risk-associated-hypertension - 2025-08-25

This study used multiple national register data from Sweden. During the 11-year follow-up period between 2005 and 2015, data from 1,167,449 men and 542,606 women, aged 20–55 years, were accessible for inclusion in this analysis. Incidence of obesity was identified based on a diagnosis of obesity during the follow-up period derived from clinical register data. Neighborhood availability of fast-food

https://www.lupop.lu.se/article/fast-food-outlets-physical-activity-facilities-and-obesity-among-adults-nationwide-longitudinal - 2025-08-25

A total of 413 000 people with T2D aged <66 years, comprising 4.9 million person‐years, was included. The crude proportion with any absence was higher among those with T2D compared to controls (47% vs. 26%) in the index year, and the median (IQR) number of days was higher (223 [77;359] vs. 196 [59;352]) if any absence. Regression analyses showed that complications per se were a key driver of days

https://www.lupop.lu.se/article/days-absent-work-result-complications-associated-type-2-diabetes-evidence-20-years-linked-national - 2025-08-25

The term “fracture cascade” refers to the sequence of fragility fractures resulting from the increased fracture risk that occurs with aging and following fractures. Here, we evaluate the sequence of previous fractures in women aged 55 to 90 years presenting with a fragility fracture and subsequent (12 to 24 months) fracture incidence. In this retrospective, observational study, women aged 55 to 90

https://www.lupop.lu.se/article/history-previous-fracture-and-imminent-fracture-risk-swedish-women-aged-55-90-years-presenting - 2025-08-25

Socioeconomic status is an important determinant of health, the measurement of which is of great significance to population health research. However, individual-level socioeconomic factors are absent from much health administrative data, resulting in widespread use of area-level measures in their place. This study aims to clarify the role of individual- and area-level socioeconomic status in Ontar

https://www.lupop.lu.se/article/agreement-between-area-and-individual-level-income-measures-population-based-cohort-implications - 2025-08-25

This was a retrospective cohort study carried out in eight health facilities in two regions of Ethiopia. Adolescents (age 10–14 and 15–19 year) and children (age 0–9 year) enrolled in chronic HIV care between 2005 and 2013 constituted the study population. We reviewed the individual patient charts between March and June 2014 and updated the data on the status of each patient through December 2015.

https://www.lupop.lu.se/article/adolescents-living-hiv-are-higher-risk-death-and-loss-follow-care-analysis-cohort-data-eight-health - 2025-08-25