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Idiopathic Parkinson’s disease (PD) is a complex disease caused by multiple, mainly unknown, genetic and environmental factors. The Ventral root avulsion 1 (Vra1) locus on rat chromosome 8 includes the Glutathione S-transferase alpha 4 (Gsta4) gene and has been identified in crosses between Dark Agouti (DA) and Piebald Virol Glaxo (PVG) rat strains as being associated to neurodegeneration after ne
Here, we introduce a novel scFv antibody, G2-D11, specific for two adjacent Tn-antigens (GalNAc- Ser/Thr) binding equally to three dimeric forms of the epitope, Ser-Thr, Thr-Thr and Thr-Ser. Compared to other anti-Tn reagents, the binding of G2-D11 is minimally influenced by the peptide structure, which indicates a high degree of carbohydrate epitope dominance and a low influence from the protein
Molecules often fragment after photoionization in the gas phase. Usually, this process can only be investigated spectroscopically as long as there exists electron correlation between the photofragments. Important parameters, like their kinetic energy after separation, cannot be investigated. We are reporting on a femtosecond time-resolved Auger electron spectroscopy study concerning the photofragm
Detta paper är en del i en fallstudie som undersöker vad musikhögskolestudenter lär sig genom att delta i amatörorkesterverksamhet och vad det tillför utbildningen. Studien består av åtta intervjuer, fyra med utbildningsledning för en musikhögskola och fyra med dirigenter för amatörorkestrar där musikhögskolestudenter deltar. Här presenteras endast den del som rör relationen mellan musikhögskolan
It is well known that Franz Liszt was fond of the harp as an instrument, and his use of the harp in the orchestra is innovative. He also befriended and worked with prominent harpists of his time, such as Elias Parish-Alvars, Wilhelm Posse, Jeanne Pohl and Rosalie Spohr. The transcriptions he once made for harp are now lost. However, a recent finding in a collec- tion in a Swedish museum, Murberget
Operating systems code is often developed according to principles like simplicity, low overhead, and low memory footprint. Schedulers are no exceptions. A scheduler is usually developed with flexibility in mind, and this restricts the ability to provide real-time guarantees. Moreover, even when schedulers can provide real-time guarantees, it is unlikely that these guarantees are properly quantifie
The large spatial variability in Arctic tundra complicates the representative assessment of CO2 budgets. Accurate measurements of these heterogeneous landscapes are, however, essential to understanding their vulnerability to climate change. We surveyed a polygonal tundra lowland on Svalbard with an unmanned aerial vehicle (UAV) that mapped ice-wedge morphology to complement eddy covariance (EC) fl
We present a comprehensive investigation of the charge-transfer (CT) effect in weakly interacting organic semiconductor mixtures. The donor-acceptor pair diindenoperylene (DIP) and N,N′-bis(2-ethylhexyl)-1,7-dicyanoperylene-3,4/9,10-bis(dicarboxyimide) (PDIR-CN2) has been chosen as a model system. A wide range of experimental methods was used in order to characterize the structural, optical, elect
The paper explores the impact of El Niño-Southern Oscillation (ENSO) on rainy season precipitation properties over the Yangtze River Basin. The multi-scale moving t-test was used to determine the onset and withdrawal of the rainy season. Results showed the following: (1) Onset and withdrawal of the averaged rainy season over the Yangtze River Basin showed a similar distribution and both progressed
The small-disturbance electro-mechanical dynamics of a power system can be translated to an equivalent circuit model with inductances and capacitances. Damping control of active power in proportion to local frequency as with a VSC-HVDC link or an energy storage then corresponds to introducing a resistor in the circuit model. This letter shows that impedance matching can be used to select resistor
Optimal currents on arbitrarily shaped radiators with respect to the minimum quality factor are found using a simple and efficient procedure. The solution starts with a reformulation of the problem of minimizing quality factor Q as an alternative, so-called dual, problem. Taking advantage of modal decomposition and group theory, it is shown that the dual problem can easily be solved and always res
Level crossing sampling (LCS) is a power-efficient analog-to-digital conversion scheme for spikelike signals that arise in many Internet of Things-enabled automotive and environmental monitoring applications. However, LCS scheme requires a dedicated time-to-digital converter with large dynamic range specifications. In this paper, we present a compressed LCS that exploits the signal sparsity in the
To obtain better fluid mixing and higher heat transfer rate in the low Reynolds number regime, various types of fins have been employed for electronic cooling applications. However, previous works showed that there are no remarkable differences in the thermal performance of a straight-plate and a channel with louvered-fins when the Reynolds number is low or moderate. In this paper, the Constructal
The Scandinavian countries have a long history of active labour market policy, using activation to promote work among those with no problems besides unemployment. However, activation policy is now permeating social policies providing economic protection for young adults who cannot work for health reasons, which has been legitimised through a strong emphasis on paid work as the main source of socia
The current paper addresses the implications of doing research on socially assistive robots in real homes. In contrast to laboratory studies, studies of robots in their intended natural environments can provide insights into people’s experiences of robots, and if and how a robot becomes embedded and used in people’s everyday life. However, moving robots out of the lab and into real life environmen
Understanding and managing coupled human and natural systems (CHANS) is a central challenge of the 21st century, but more focus is needed to pursue the most important questions within this vast field given limited research capacity and funding. We present 40 important questions for CHANS research, identified through a two-part crowdsourcing exercise within the CHANS community. We solicited members
