Compression algorithm for pre-simulated Monte Carlo p-value functions: Application to the ontological analysis of microarray studies
Monte Carlo simulation is frequently employed to compute p-values for test statistics with unknown null distributions. However, the computations can be exceedingly time-consuming, and, in such cases, the use of pre-computed simulations can be considered to increase speed. This approach is attractive in principle, but complicated in practice because the size of the pre-computed data can be prohibit
