Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer
Background: Standard anti-proliferative chemotherapy is relatively ineffective against slowly proliferating androgen-independent prostate cancer cells within metastatic sites. In contrast, the lipophilic cytotoxin thapsigargin, which causes apoptosis by disrupting intracellular free Ca2+ levels, is effective against both proliferative and quiescent (i.e., G(0)-arrested) cells. However, thapsigargi
