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Background: Cardiovascular risk factor control reduces the risk of recurrent events after acute coronary syndrome (ACS). Long-term post-ACS management is poorly studied. Objectives: To assess frequency of low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP) monitoring and target achievement during 3 years post-ACS. Methods: Data from all patients hospitalized for ACS in Up

Bacteriophages must overcome diverse bacterial immune systems, yet the molecular principles enabling such escape remain poorly understood. Here, we show that the phage homing endonuclease SegB facilitates immune evasion by promoting the segmental amplification of anti-defense loci. The antiphage defense Septu inhibits phage T6 replication by cleaving the variable loop of tRNATyr. We show that SegB

In 2024, the European Academy of Paediatrics (EAP) published a list of 10 low-value practices in paediatric care. Embedded in the Choosing Wisely framework, this list is a step towards promoting targeted and evidence-based care. However, no single recommendation can change prescription habits and we need to acknowledge that overuse of the available resources has multiple causes. Among them, the ph

Software applications can be described using a computational model. These Models of Computation (MoCs) define rules governing application behaviour and properties that are enforced during execution. This thesis focuses on an actor-based MoC, known as dataflow-with-firing, where applications are modelled as actors connected by buffered channels. This model yields a concurrent application descriptio

If asset prices have no jumps it is known that the growth optimal Kelly strategy lies on the local efficient frontier, that is has maximal instantaneous Sharpe ratio. In this paper we show that, when asset prices have jumps, this property ceases to hold. However, the discrepancy is small for jumps with magnitude less than 25%. Our results further indicate that a Kelly trader fears market crashes b

Consolidation of dwellings in self-help settlements is directly dependent on the generation of surplus resources beyond that required for subsistence. A significant proportion of households in such settlements are reliant on income generated within the home for household subsistence as well as to finance the construction of the dwelling itself. There is therefore a close interrelationship between

Sammanfattning Kapitel 2 Presentation av ett nytt tumör-behandlingskoncept med ”Pre-kirurgisk intermittent ultrahypofraktionerad strålbehandling” (PSiRT) ”kombinerad med immunterapi” (PSiRIT), särskilt immun¬kontrollpunktshämmare (anti-CTLA4 och anti-PD-1).Intermittent ultrahypofraktionerad strålbehandling innebär:• Optimal absorberad dos 6–8 Gy per fraktion • Doser >10 Gy kan öka immunosuppressiv

Land markets in African cities are characterised by the co-existence of different modes of supply that originate from the different stages of their development. Customary land tenure remains important in many of these cities, although its future is widely disputed. This paper discusses the implications of the co-existence of customary land tenure and state involvement in the land market in peri-ur

Critical events frequently occur in hospital settings. Cinematic portrayals of medicine and medical environments can illuminate historical developments and perspectives on healthcare, medical professions, and specialisations. This article aimed to explore the interplay between structural framework, professional, and relational factors when facing critical events and their management in a hospital

We develop a theory and perform an experiment to study the effect of performance thresholds on effort and risk-taking in economic decisions. We find that effort unambiguously increases compared to the ``status quo" level, but that optimal effort varies non monotonically with the threshold level. The effect of a threshold on risk-taking in instead ambiguous, as risk taking increases for thresholds

The aim of this dissertation is to map out and illustrate particularly troublesome and central areas in grammar learning. The point of departure is Josefsson and Lundin’s three suggested threshold concepts within grammar: to be able to distinguish between meaning, form and function, to be able to distinguish between a linear and a hierarchical dimension and to be able to identify and segment claus

We study attitudes toward offering monetary payments for vaccination. We develop the Policy Lab, an experimental paradigm to characterize policy preferences in which participants decide whether to implement actual interventions to influence others' real-world behavior. In two studies with representative samples of the Swedish population (N=2,010) and one with Swedish policymakers (N=2,008), partic

Background: Helicobacter pylori (Hp) and its virulence factor Cytotoxin-associated gene A (CagA) have been linked to myocardial infarction (MI), but the mechanisms are unknown. This study aims to test if Hp infection and CagA are associated with pre-specified inflammatory and vascular biomarkers in patients with MI and to explore whether a broader biomarker panel can predict infection. Furthermore

Understanding the physical properties and flow behaviour of foods is essential for designing reliable processing equipment. In this thesis, the rheological properties and flow behaviour of Pasta Filata cheese are investigated to improve the understanding of the flow-distribution inside a Tetra Pak Cheese Extruder. Uneven flow-rates have been observed during production, which lead to inconsistent d

Detta kandidatarbete undersöker transformationen av den historiska Marieholms Yllefabrik till ett modernt kontorshotell. Syftet är att genom arkitektonisk återanvändning väcka liv i ett industriarv som stått sysslolöst sedan 2002 och därmed bidra till lokal vitalisering och hållbarhet.Visionen fokuserar på mötet mellan gammalt och nytt, där fabrikens befintliga betongstruktur och tegelfasader beva

Objective Transcriptomic subtyping is not yet standardized for prognostic use in epithelial ovarian cancer (EOC). This study aims to validate RNA sequencing (RNAseq) from formalin-fixed, paraffin-embedded (FFPE) tissues and to evaluate survival-associated transcriptomic subtypes and differentially expressed genes (DEGs) in a clinical trial cohort. Methods An exploratory post hoc analysis was condu

We present the design and implementation of a portable transfer system equipped with an integrated electrochemical cell that enables the controlled transfer of samples between an electrochemical environment and an ultrahigh vacuum (UHV) system without air exposure. This setup allows for the preparation of well-defined model surfaces, their electrochemical modification, and subsequent structural an

This study presents high-fidelity Large Eddy Simulations (LES) of supersonic combustion in a Mach 2 cavity flameholder over the full stable fueling region from 40 to 200 slpm. The simulations employ Finite Rate Chemistry LES with the Z70 ethylene-air mechanism, the Localized Dynamic k-equation model, Partially Stirred Reactor turbulence-chemistry interaction model, conjugate heat transfer, and the