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The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeostasis. This study investigates the consequences of VSMC-specific YAP/TAZ deletion and its relevance to atherosclerosis. Using bulk and single-cell RNA sequencing data, we demonstrate that gene expression changes following two (2-week YT) and eight w

Background and purposeHYPO-RT-PC was the first phase 3 trial showing the long-term efficacy and safety of extremely hypofractionated radiotherapy schedules (ultra-hypofractionation or stereotactic body radiotherapy) compared with standard radiotherapy in localised prostate cancer. We aimed to verify their safety in the context of a clinical trial, by comparing events of potentially radiotherapy-re

Increasing evidence suggests that microRNAs (miRNAs) contribute to pancreatic β-cell compensation during type 2 diabetes (T2D) pathogenesis. To examine miRNA-mRNA interactions in human islets and their roles in β-cell insulin secretion and T2D, we performed small-RNA sequencing on pancreatic islets from nine individuals with T2D and 52 non-diabetic controls. We identified 70 differentially express

While pregnancy clearly reduces the risk for Alcohol Use Disorder (AUD) onset, we know less about the impact on AUD risk of having young children and how these effects vary across maternal age and level of maternal AUD genetic risk. Therefore, in 1.2 million parous Swedish women born 1960-1995, we examined those with a first registration for AUD between ages 15-40 while first pregnant, or while ra

BACKGROUND: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on dise

This thesis explores how femininity is constructed within the soft girl trend, using Butler’s theoretical framework of the heterosexual matrix and theory of (gender) performativity. By combining digital ethnography, multimodal critical discourse analysis, and a critical feminist perspective, this study aims to contribute to a deeper understanding of how femininity is expressed, reproduced and aest

β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycans (GAG) that transfers the first galactose unit to xylose in the linker region. Searching for new inhibitors of the GAG biosynthesis, we used saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopy to evaluate the binding interactions between β4GalT7 and several pentosides in

BACKGROUND: This systematic review and meta-analysis aimed to assess the diagnostic test accuracy of blood-based biomarkers (BBMs) for detecting Alzheimer's disease (AD) pathology in cognitively impaired individuals in specialized care settings. The overarching goal is to inform the development of a clinical practice guideline, led by the Alzheimer's Association, for use in clinical practice. METH

We study the role of self-promotion and career advice in sustaining gender differences in labor market outcomes. We conduct an online experiment in which “advisers” advise “workers” to choose between a more ambitious and a less ambitious task based on the worker’s subjective self-assessment. We find that women have lower self-assessments and receive less ambitious career advice as a result. We als

Vi har sedan 2009 ordnat seminarier som ger klara och handfasta besked på centrala fastighetsrättsliga ämnen. Denna gång är ämnet Grannelagsrätt. Rättsförhållanden mellan grannar i 3 kap jordabalken utgör grunden för grannelagsrätten, men grannelagsrättsliga frågor regleras även i miljöbalken och plan- och bygglagen.

Due to the lower radiative fraction and typically higher storage pressures, gas temperatures can often result in longer safety distances compared to radiative heat transfer for hydrogen jet flames. The high temperatures, however, also lead to a low density causing the flow to rise at a certain distance from the release. Unfortunately, a model to determine this distance, similar to what is availabl

Fire retardants are extensively used to reduce the flammability (combustibility) of wood–based construction materials in an effort to improve fire safety of buildings. However, little is known of the composition and potential risks to human health of smoke emissions produced from combustion of fire retardant treated wood. To help understand the risk to human health, fire smoke emissions produced f

This study investigates “stiffness” optimization of path-dependent elasto-plastic structures by comparing the traditional secant stiffness formulation with a novel tangent stiffness formulation. Design updates are generated using the gradient-based Method of Moving Asymptotes (MMA), and the material behavior is modeled and limited to small-strain elasto-plasticity and isotropic hardening. Numerica

Vision impairment increases risks such as social isolation, mobility challenges, and falls. Wearable Augmented Reality (AR) devices with Artificial Intelligence (AI) can enhance sensory perception by enabling real-time recognition of obstacles, assisting visually impaired individuals during street navigation, aiming to reduce the risk of falls. In this paper, we propose a Federated Learning (FL) f

The fire behaviour of bio-based insulation materials is studied by comparing results from Cone Calorimeter and small-scale furnace tests. Clear differences in fire behaviour were observed between wood fibre and hemp fibre insulation. The analysis reveals that smouldering plays a critical role, particularly in furnace tests. Limitations of current fire resistance tests are highlighted, particularly

Bio-based insulation materials, such as wood fiber, offer sustainable alternatives to conventional insulation but pose challenges due to their combustibility, particularly their smouldering behavior. This study investigates the heat release characteristics of wood fiber insulation using a combination of Simultaneous Thermal Analysis (STA) and Microscale Combustion Calorimetry (MCC) to assess both

Background: Various plasma phosphorylated tau species have been shown to be associated with amyloid-β (Aβ) PET and Tau PET in Alzheimer’s disease (AD), but whether APOE ε4 affects the interaction between glial fibrillary acidic protein (GFAP) and phosphorylated tau (pTau), and whether a three-way interaction exists among APOE ε4, GFAP, and pTau that influences AD progression remain unclear. Method

Despite significant progress in oncology research, pancreatic cancer remains inherently difficult to treat, and the mechanisms underlying therapeutic resistance remain unresolved. Decorin (DCN), a member of the family of small leucine-rich proteoglycans, has emerged as a versatile actor in various malignant diseases. The aim of this study was to further explore the potential clinical significance