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Molecular pathological epidemiology research provides information about pathogenic mechanisms. A common study goal is to evaluate whether the effects of risk factors on disease incidence vary between different disease subtypes. Read the paper at https://academic.oup.com/ije/article/50/3/1030/6114706
New research at Lund University shows that the biological parents’ genes affect the child's insulin function and capacity to regulate blood sugar levels and blood lipids in different ways. Such knowledge may be used to develop preventive treatments that reduce the child's risk of developing type 2 diabetes and cardiovascular disease. Previous research by diabetes researcher Rashmi Prasad has shown
https://www.ludc.lu.se/article/new-study-parents-metabolic-traits-can-affect-childs-health-over-time - 2025-10-07
The results of an observational study from Lund University in Sweden are clear: up to the age of two, a more fibre-rich diet seems to reduce the risk of coeliac disease. A particularly clear link was seen when children had eaten fibre-rich foods before the age of one. “This is the first time the risk of coeliac disease has been studied based on fibre in children’s diets. But a clinical trial is al
Type 2 diabetes is a chronic disease that usually requires lifelong treatment. A central goal for many diabetes researchers is to develop new cell therapies that can cure the disease. The Bo and Kerstin Hjelt Diabetes Foundation provides support to two diabetes researchers at Lund University Diabetes Centre who contribute with new knowledge to this research field. Type 1 diabetes is a condition wh
https://www.ludc.lu.se/article/hjelt-diabetes-foundation-supports-research-can-pave-way-new-cell-therapies - 2025-10-07
International researchers who study islets of Langerhans met for a conference in Malmö in June. Studies of insulin-producing cells help us understand disease mechanisms in diabetes. Lund University Diabetes Centre and the strategic research area EXODIAB hosted the event. Lund University Diabetes Centre (LUDC) and the strategic research are EXODIAB (Excellence of Diabetes Research in Sweden) hosted
https://www.ludc.lu.se/article/international-islet-cell-researchers-met-conference-malmo - 2025-10-07
Congratulations to Charlotte Ling who, together with Katarina Fagher and Alice Maguolo, has been awarded a grant of five million Danish kroner by the Novo Nordisk Foundation. The funding will support clinical research in precision medicine, focusing on epigenetic analysis of blood samples from 13,000 individuals. Charlotte Ling, a professor in diabetes research with a particular focus on epigeneti
https://www.ludc.lu.se/article/charlotte-ling-receives-major-grant-clinical-diabetes-research - 2025-10-07
An international research team led from Lund University, has identified epigenetic biomarkers that can predict which people with type 2 diabetes are at risk of cardiovascular disease. The study is now published in Cell Reports Medicine. People with type 2 diabetes are up to four times more likely to have heart attacks, strokes, anginas and other coronary heart diseases than healthy people. Therefo
https://www.ludc.lu.se/article/biomarkers-reveal-risk-cardiovascular-disease-type-2-diabetes - 2025-10-07
Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world. In a review in Science, Mark McCarthy, professor at the University of Oxford, UK, and Paul Franks, professor at Lund University, Sweden, examine the knowledge of the actual causes and the interplay between genetics and lifestyle factors. By studying how our genes express themselves in response
https://www.ludc.lu.se/article/review-type-2-diabetes-and-obesity-what-do-we-really-know - 2025-10-07
Lund University Diabetes Centre has entered into a collaboration with the Regeneron Genetics Center LLC (RGC) and the University of Helsinki involving exome-sequencing and whole genome array genotyping of greater than 9,000 individuals. The collaboration will involve the largest sequencing study in diabetes families to date and aims to help generate knowledge about how to predict diabetes, causes
Research from Lund University in Sweden can explain why type 2 diabetes is inherited to a greater extent from an individual’s mother. The heredity of a previously known risk gene, THADA, has proven to be dominant if it comes from the mother, whereas it has little or no effect on the child’s risk of disease if it originates from the father. “Our research contributes to increased knowledge about the
https://www.ludc.lu.se/article/thada-new-findings-role-mother-type-2-diabetes - 2025-10-07
A new experimental and clinical study from Lund University in Sweden shows that the sleep hormone melatonin impairs insulin secretion in people with a common gene variant. “This could explain why the risk of type 2 diabetes is greater among, for instance, overnight workers or people with sleeping disorders”, says Professor Hindrik Mulder who is responsible for the study. Melatonin is a naturally
https://www.ludc.lu.se/article/new-findings-explain-connection-between-melatonin-and-type-2-diabetes - 2025-10-07
One in three people with diabetes will face some form of renal impairment in the course of their lives. Studies conducted by researchers at the Lund University Diabetes Centre may lead to the development of an entirely new principle for treating type 2 diabetes and preventing kidney damage in the future. Previous analyses have not been able to identify genetic causes as to why some people have a h
https://www.ludc.lu.se/article/new-findings-can-lead-new-principle-treating-diabetic-kidney-damage - 2025-10-07
One in three people with diabetes will face some form of renal impairment in the course of their lives. Studies conducted by researchers at the Lund University Diabetes Centre may lead to the development of an entirely new principle for treating type 2 diabetes and preventing kidney damage in the future. Previous analyses have not been able to identify genetic causes as to why some people have a h
https://www.ludc.lu.se/article/new-findings-can-lead-new-principle-treating-diabetic-kidney-damage-0 - 2025-10-07
The European Research Council makes a large investment in diabetes research. A project led by Professor Paul Franks at Lund University Diabetes Centre is to develop methods that can be used in the design of preventive treatment for type 2 diabetes and cardiovascular disease. - Through this project we will use functional genomics and epidemiology to identify novel molecular mechanisms that underlie
https://www.ludc.lu.se/article/focus-personalized-treatment-type-2-diabetes-and-cardiovascular-disease - 2025-10-07
Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world. In a review in Science, Mark McCarthy, professor at the University of Oxford, UK, and Paul Franks, professor at Lund University, Sweden, examine the knowledge of the actual causes and the interplay between genetics and lifestyle factors. By studying how our genes express themselves in response
https://www.ludc.lu.se/article/type-2-diabetes-and-obesity-what-do-we-really-know - 2025-10-07
Obesity is associated with reduced muscle mass and impaired metabolism. Epigenetic changes that affect the formation of new muscle cells may be a contributing factor, according to new research from Lund University, Sweden. In a new study, doctoral student Cajsa Davegårdh has studied so-called DNA methylation in muscle stem cells in both obese and non-obese individuals. DNA methylation is an epigen
https://www.ludc.lu.se/article/obesity-reprogrammes-muscle-stem-cells - 2025-10-07
BEAt-DKD (“Biomarker Enterprise to Attack Diabetic Kidney Disease”), a unique public private partnership funded by the Innovative Medicines Initiative (IMI), member companies from the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Juvenile Diabetes Research Foundation (JDRF) and the state of Switzerland has announced the launch of a 5-¬¬year project (total budget 28
https://www.ludc.lu.se/article/innovative-medicines-initiative-project-precision-medicine-dkd - 2025-10-07
Almost 0.5 billion people have diabetes globally, many of whom are unaware of their condition; within the next two decades, this number is expected to double, largely owing to a growing, ageing, and increasingly industrialized global population. Lund University receives 100 million SEK from The Swedish Foundation of Strategic Research to help stop this development. “This is excellent news and a fa
https://www.ludc.lu.se/article/100-million-sek-personalized-medicine-diabetes - 2025-10-07
Throughout our lives, our genes are affected by the way we live. Diet, exercise, age and diseases create imprints that are stored in something called methylome. Now, for the first time, researchers at the Lund University Diabetes Centre in Sweden have been able to map the entire methylome in the pancreatic islets which produce insulin, and the researchers have made several important discoveries. U
https://www.ludc.lu.se/article/unique-mapping-methylome-insulin-producing-islets - 2025-10-07
Den 13 februari genomfördes den första stamcellstransplantationen i studien STEM-PD. Det är den första av åtta patienter med Parkinsons sjukdom som får nya dopaminproducerande stamceller transplanterade och det är första gången cellerna testas kliniskt i patienter. Transplantationen genomfördes vid Skånes universitetssjukhus och produkten som transplanterades har utvecklats av forskare vid Lunds u
https://www.medicin.lu.se/artikel/milstolpe-stamcellsbaserad-terapi-vid-parkinson-forsta-patienten-transplanterad-1 - 2025-10-07
