In blood, complement proteins are a major component and perhaps therefore most of these were identified already decades ago. However, only in recent years it has become apparent that complement not only plays a major role in innate defense against pathogens but also identifies foreign materials and removes waste (immune complexes and dying cells). The physiological relevance of complement is demon

https://www.protein-chemistry.lu.se/projects - 2025-06-21

We are studying an unexpected role of complement – in the physiology and metabolism of pancreatic beta-cells. Surprisingly, this is related to intracellular functions of complement and therefore changes the way we perceive this “blood” system and will likely inspire discovery of many other intracellular effects of complement. We study the role of intracellular complement factor C3 and membrane bou

https://www.protein-chemistry.lu.se/projects/insulin-and-immunity-when-complement-takes-control - 2025-06-21

As a first line of defense against pathogens and a mediator between innate and adaptive immunity, complement is a particular focus of evasion strategies developed by pathogens.  We showed that one common strategy is to bind complement inhibitor C4BP, which leads to decreased opsonisation of bacteria with C3b impairing phagocytosis and allowing bacterial survival. It appears that binding of C4BP is

https://www.protein-chemistry.lu.se/projects/bacterial-complement-evasion-strategies - 2025-06-21

  Myriam Martin, Rebecca Trattner and Anna Blom Misguided or excessive complement activation is involved in many common diseases such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis and age-related macula degeneration. In collaboration with clinicians we are studying molecular mechanisms of complement involvement in these diseases. Joint inflammation in rheumatoid arthritis (RA),

https://www.protein-chemistry.lu.se/projects/pathologic-complement-activation-diseases - 2025-06-21

Expression of COMP in breast cancer tissue Complement-dependent cytotoxicity is one of the mechanisms by which therapeutic monoclonal antibodies are toxic to cancer cells. Also, complement is currently undergoing re-appreciation of its role in the immune surveillance of tumors. The majority of human tumors are low immunogenic and complement may be involved in their recognition via direct “danger s

https://www.protein-chemistry.lu.se/projects/complement-and-cancer - 2025-06-21

Complement has recently gained substantial worldwide attention, as it was discovered that several common diseases such as age-related macular degeneration (blindness in elderly) are related to deregulation of the balance between complement activation and inhibition. Full complement deficiencies lead to severe infectious and autoimmune diseases but are uncommon while it appears that we are just beg

https://www.protein-chemistry.lu.se/projects/inherited-deficiencies-complement-inhibitors - 2025-06-21

Myriam Martin, Rebecca Trattner and Anna Blom  You can reach us by mailor by calling 040-33 78 30 and 040-33 15 20Vaishnavi Dandavate, postdoctoral fellowE-mail: vaishnavi [dot] dandavate [at] med [dot] lu [dot] se (vaishnavi[dot]dandavate[at]med[dot]lu[dot]se)Daniel Chacón Arguedas, postdoctoral fellowE-mail: daniel [dot] chacon_arguedas [at] med [dot] lu [dot] seAlexander Ekström, PhD studentE-m

https://www.protein-chemistry.lu.se/members-our-research-group - 2025-06-21

Here you can find description of open positions and internships in our research group. MSc StudentsWe often can offer thesis projects for Masters students within the projects conducted in our group. Please, contact Anna Blom (Anna [dot] Blom [at] med [dot] lu [dot] se (Anna[dot]Blom[at]med[dot]lu[dot]se)) directly for more details.PhD StudentsWe are always interested in reviewing PhD students appl

https://www.protein-chemistry.lu.se/open-positions - 2025-06-21

Research funding supporting projects conducted in our research group: Swedish Research Council Cancerfonden Torsten Söderberg Foundation ALF Knut and Alice Wallenberg Foundation Novo nordisk fonden Erling-Persson Family Foundation Alfred Österlund Foundation  Grants for clinical research from Skåne University Hospital (including cancer) King Gustav Vth, 80-years Anniversary Foundation Diabetesfond

https://www.protein-chemistry.lu.se/research-funding - 2025-06-21

Medical Protein Chemistry Group. Who are we? Professor Anna Blom leads the Medical Protein Chemistry group Projects conducted in our research group Open positions Lund University Diabetes Centre Department of Translational Medicine

https://www.protein-chemistry.lu.se/protein-chemistry - 2025-06-21

The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö. The group is focused on the complement system in health and disease. Our ambition is to make high quality basic science based on clinically relevant questions and yielding novel diagnostic approaches and clinical interventions. Our research is su

https://www.protein-chemistry.lu.se/anna-blom-research-group - 2025-06-21

Leading research in psychological defence About the institute... The Lund University Psychological Defence Research Institute (Forskningsinstitutet för psykologiskt försvar) is a multidisciplinary research unit within the Department of Communication. Our work focuses on the theory and practice of psychological defence, with a focus on research into analyzing and countering hostile information infl

https://www.psychologicaldefence.lu.se/start - 2025-06-21

The Lund University Psychological Defence Research Institute (Forskningsinstitutet för psykologiskt försvar) is a multidisciplinary research unit within the Department of Communication. Our work focuses on the theory and practice of psychological defence and research into analyzing and countering hostile information influence operations and hybrid threats. The purpose of psychological defence is t

https://www.psychologicaldefence.lu.se/about-institute - 2025-06-21

Attribution – Data – Analysis – Countermeasures. InterOperability ADAC.io is a Horizon project coordinated by the Psychological Defence Research Institute As of 1 February 2024, the Psychological Defence Research Institute coordinates the Horizon project ADAC.io, engaging seven partners in a three-year-long project. Based on the concept of Foreign Information Manipulation & Interference (FIMI) as

https://www.psychologicaldefence.lu.se/adacio - 2025-06-21

Below are some of the main publications by the Psychological Defence Research Institute and our affiliates. 2025Pamment, J. & Tsurtsumia, D. (2025). Beyond Operation Doppelgänger: A Capability Assessment of the Social Design Agency. MPF Report Series, 8/2025, 1-194.Ördén, H. (2025). A genealogy of Swedish psychological defence: Information influence as a shifting problem for democratic governance.

https://www.psychologicaldefence.lu.se/research - 2025-06-21

Researcher profiles feature researchers connected to the Psychological Defense Research Institute as affiliates, visiting researchers, or employees. Hilkka Grahn Rolf Fredheim Elsa Hedling

https://www.psychologicaldefence.lu.se/researcher-profiles - 2025-06-21

Följ det Vetenskapsrådsfinansierade forskningsprojektet ”Döden på Vipeholm – en undersökning om vården av ’osnygga obildbara sinnesslöa’ och möjlig medveten dödssvält”. Om projektet Under några av 1940-talets första år dog 200 av de patienter som bodde på Vipeholms sjukhus. Vad berodde det på, att så många dog under de här åren? Kan det ha handlat om eutanasi – vilket har framförts men aldrig lett

https://www.vipeholm.lu.se/vipeholm - 2025-06-21

Artikel av Kristina Engwall i Nordic Journal of Educational History”… äro absolut obildbara”: Barnen på Vipeholm 1935–1963DOI: https://doi.org/10.36368/njedh.v11i1.456Abstract: Hospital in Sweden was the only institution for the ’uneducated, difficult to care for feebleminded’. Although it was designed for adults, a fifth of those admitted were under the age of 15. The article focuses on the child

https://www.vipeholm.lu.se/om-projektet/publicerat - 2025-06-21

Elin Bommenel skriver om sjukhuschefen och överläkaren Hugo Fröderberg Under sitt långa yrkesliv fick Hugo Fröderberg (1897–1986) följa utvecklingen av vad som då kallades ”sinnesslövården”. För eftervärlden kom han att bli känd som sjukhuschef och överläkare på Vipeholms sjukhus – Europas största i sitt slag med plats för nästan 1000 ”svårskötta, obildbara sinnesslöa”. Hugo Fröderberg föddes i Bä

https://www.vipeholm.lu.se/vem-var-hugo-froderberg-och-vad-var-vipeholms-sjukhus - 2025-06-21

Ett tvärvetenskapligt forskningsprojekt om Vipeholm Under krigsåren 1941–1943 dog ett ovanligt stort antal intagna på Vipeholm. Varför vet vi inte med säkerhet ännu. Genom tvärvetenskaplig arkivforskning arbetar fyra forskare med att ta reda på vad som egentligen hände. Hur tar ett välfärdssamhälle hand om sina marginaliserade, mest sårbara invånare? Och hur har synen förändrats på de människor so

https://www.vipeholm.lu.se/om-projektet - 2025-06-21