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Objective: To describe arterial stiffness, ankle-brachial index (ABI), advanced glycation end products (AGE) and glycosylated hemoglobin (HbA1c) in middle-aged people with cervical and upper thoracic SCI, and compare findings with the general population. Design: Cross-sectional study with matched controls. Setting: Tertiary outpatient SCI unit in southern Sweden. Participants: Participants (n = 25

Sexual selection in simultaneous hermaphrodites can act through male–male competition and female choice, often favouring male-biased traits, yet remains understudied relative to gonochorists. We tested how sex-limited experimental evolution alters mating behaviour and the male copulatory organ (the stylet) in Macrostomum lignano. After more than 40 generations of selection for male- or female-spec

Biological strategies for manipulating light have revealed new concepts in light scattering, inspiring the design of sustainable photonic materials. While iridescent optical systems have been extensively studied, many applications require noniridescent structural colors which are much more difficult to achieve. Photonic glasses, comprising randomly arranged dielectric spheres, offer a promising so

Nitrogen availability is thought to be a key factor that modifies the strength and direction of plant-soil feedback (PSF), but how nitrogen availability and PSF interact in forests remains unresolved. For example, PSF is one of the drivers underpinning the well-known nursing effect in the Atlantic forests of the UK and Ireland. In these systems, the nursing effect occurs when Scots pine ( Pinus sy

We show the following hardness results for monotone learning and approximation of monotone circuit size: 1. Under the Randomised Exponential-Time Hypothesis (rETH), it requires time nΩ(log n) to PAC-learn monotone formulas with n input bits and size s(n) = n by monotone circuits of size n(log n)1−ϵ, for every ϵ > 0. 2. Under the Randomised Exponential-Time Hypothesis (rETH), for any δ > 0, there i

Objective: Suture-mediated closure devices have enabled totally percutaneous endovascular aneurysm repair (EVAR). Although hemorrhagic access-site complications are well recognized, closure-device related common femoral artery (CFA) stenosis or dissection is less well described. We report the use of an endovascular bailout strategy for these complications and assess midterm outcomes. Methods: Betw

Through Arctic amplification, global climate change is projected to disproportionally affect high-latitude environments. Additionally, the geographical heterogeneity and complex terrain of mountains promote climate-driven ecological change on fine spatial scales. We used a high-resolution convection-permitting regional climate model (HCLIM) and a state-of-the-art dynamic vegetation model (LPJ-GUES

Public debate is central to most theories of democracy, yet few cross-national studies have examined its association with democratic satisfaction. This article identifies three features of national public spheres – pluralism, information, and respect – and presents annual measures of these features for 175 countries from 2000 to 2020. Among electoral democracies, pluralism remained stable, but the

The Telychian Age (Llandovery, Silurian) is marked by significant radiation among marine organisms, a faunal turnover, and palaeoenvironmental changes, collectively known as the Valgu Bioevent (Valgu BE), Valgu Carbon Isotope Excursion (Valgu CIE), and the Valgu Oxygen Isotope Excursion (Valgu OIE). However, the environmental drivers of these changes remain debated. Here we investigate the middle

The Self-Concordance Model posits that autonomously motivated goal pursuit is a primary driver of well-being, yet standard measurement practices often conflate the presence of autonomy with the absence of external pressure via relative difference scores. Using a high-powered dataset (N = 429), this study tested a Balance Model against an Autonomous-Primary Model. Using Bayesian structural equation

Background: Individuals with diabetes have an increased risk of cardiovascular disease, infection, hospitalization, and premature mortality. However, less is known about how diabetes shapes the broader pattern of emergency department (ED) presentations, acute care use, clinical complexity, and short-term mortality in an unselected ED population. We aimed to describe ED presentation patterns and ou

DNA methylation deregulation is an essential feature of tumor biology, influencing cancer formation and pathogenesis. Analyses of DNA methylation in bulk cancer specimens are challenging due to the high data dimensionality, noise, and mixture of different cell types. Here, we characterized methylation dynamics in cancer by investigating the variance structure of bulk tumor DNA methylation data thr

BACKGROUND: Pheochromocytomas and paragangliomas (PPGLs) are rare and mostly non-metastatic tumors originating from adrenal medulla and paraganglia. Metastatic PGLs have a worse prognosis, but currently, there are no established criteria to determine PPGL metastatic potential.AIM: The aim of this study was to investigate whether SDHB and CDK1 expression is associated with metastatic capacity in PP

Background: Uterine sarcomas are rare and high-quality evidence regarding optimal treatment is limited and difficult to produce. Methods: A total of 618 patients with uterine sarcoma were identified in the Swedish Quality Registry for Gynecologic Cancer (SQRGC) from 2010 to 2020. Survival was analyzed according to stage, histology and treatment modality. Results: The incidence of uterine sarcoma w

Obesity-related type 2 diabetes (T2D) is currently defined by insulin resistance and impaired insulin secretion. Sulfonylureas, thiazolinediones, and insulin are effective at lowering glycemia yet have not consistently translated into improved long-term outcomes. In contrast, recent interventions often produce metabolic benefits that exceed expectations based on glucose lowering alone. These contr

This paper investigates collaborative mobile edge computing (MEC) servers for large language model (LLM) inference under soft deadline constraints. In this system, to improve the quality of service, computations are expected to be completed within their deadlines. However, due to dependencies among tasks or subtasks, any missed deadline can lead to catastrophic consequences for the entire request.

Context. Star formation (SF) remains an incompletely understood concept essential to many fields of astrophysics. Observations show that star-forming giant molecular clouds (GMCs) form around 1 per cent or less stars per free-fall time. This trend is observed over all nearby galaxies observed to date by the Physics at High Angular resolution in Nearby GalaxieS ALMA Survey (PHANGS-ALMA) collaborati