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Mutations causing Parkinson’s disease (PD) give diverse pathological phenotypes whose cellular correlates remain to be determined. Those with PRKN mutations have significantly earlier selective vulnerability of dopamine neurons, those with SNCA mutations have increased alpha-synuclein deposition, while those with LRRK2 mutations have additional deposition of tau. Yet all three mutation types are i
This study aimed to investigate the potential impact of neighborhood deprivation on the incidence of type 2 diabetes mellitus (T2DM) among individuals with asthma. This nationwide, open cohort study conducted in Sweden from 1997 to 2018 included asthma patients of all ages (n = 1,051,240) to assess their subsequent risk of developing T2DM. The study compared asthma patients residing in highly depr
This work presents an alternative cetane rating method using a production compression ignition (CI) engine, offering an accessible approach for preliminary fuel evaluation without the need for specialized equipment. As part of this work, an empirical correlation was developed linking ignition delay (ID) to both the cetane number (CN) and intake oxygen concentration. The test method follows the pri
The Eocene period experienced several hyperthermal events with the Paleocene-Eocene Thermal Maximum being the most significant. During this event, global mean surface temperatures were 5–6 °C higher and latitudinal temperature gradients were reduced compared to the late Paleocene. Unlike marine temperature records, terrestrial archives are limited, posing challenges for testing climate model compe
Dietary fibers are recognized for their health benefits, yet cancer patients undergoing pelvic radiotherapy are often advised to reduce fiber intake. This may negatively impact their bowel health. To evaluate the effects of dietary fibers on bowel health post-irradiation, male C57BL/6 mice were fed diets containing either 0 or 15% fiber with varying proportions of readily fermentable bioprocessed
Introduction: Generalised anxiety disorder (GAD) in older adults involves excessive worry and cognitive challenges. Verbal memory impairments is associated to hippocampal dysfunction, with cortisol and brain-derived neurotrophic factor (BDNF) being important in hippocampal integrity. Research on hippocampal volume and verbal memory in older adults with GAD is limited, with mixed findings. This stu
Background: Countries around the world have committed to universal health coverage (UHC), a global vision that affirms the right for all people to access essential healthcare, when and where they need it and regardless of their ability to pay. UHC, as a political commitment, developed as part of the Sustainable Development Agenda in 2015 and, more recently, at the United Nations High-Level meeting
We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns’ abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother–child pairs from the Treatment of Obese Pregnant women (TOP) study. Fasting maternal insulin at 18-20gw was associated with abdominal/total fat mass ratio in newborns inde
Stabell and Fjeldstad (1998) proposed three value configurations; the value shop, the value chain and the value network based on Thompson’s (1967) three technologies as a typology. However, that Thompson’s technologies constitute a typology has been criticized (cf Barbini and Neri, 2017). Also, research has highlighted increased shifts in value configurations and hybrid forms. Thus, the question a
Objective: To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians. Methods: We conducted in silico data mining of previously published proteomic results using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and PHENOPEDIA databases. Results: Sixteen autoimmune disease-related proteins were identified within the proteomi
Background: To investigate a patient-level single imputation approach for patient reported outcomes (PROs) that express similar contents or associated PROs, where a PRO whose value is missing at a particular timepoint is substituted by another PRO whose value is available at the same timepoint. Methods: We performed a simulation study on registry-based spondyloarthritis data to explore the potenti
There is scientific consensus that limiting warming in line with the Paris Agreement goals requires reaching net zero CO2 emissions by mid-century and net negative emissions thereafter. Because of the entrenchment of current fossil fuel energy and feedstock demand estimated in almost all global modelled scenarios, 'abated' fossil fuel and industrial process and product use (IPPU) CO2 emissions, us
Background: The impact of air pollution and road traffic noise on depression remains inconclusive. This study examined long-term residential exposure to air pollutants and road traffic noise in relation to dispensed antidepressant medications. Methods: A cohort study was conducted using the Swedish Malmö Diet and Cancer Study, with the outcome defined as a first dispensed antidepressant (ATC: N06A
Introduction Ischaemia-reperfusion (I/R) injury remains a major challenge in heart transplantation, with mortality risk increasing significantly when allograft ischaemic time exceeds 4 hours. Non-ischaemic heart preservation (NIHP), using continuous hypothermic perfusion, has shown promise in preliminary studies for reducing I/R injury and improving outcomes. This randomised controlled trial aims
Objectives: To quantify the influence of lifestyle factors on tumour necrosis factor inhibitor (TNFi) treatment response, in axial spondyloarthritis (axSpA). Methods: Data on biologics-naïve adults with axSpA were captured from European rheumatology registries. Information on lifestyle factors (smoking, overweight/obesity, and/or alcohol consumption) were identified ± 30 days of commencing their f
The investigation of carbon monoxide (CO) adsorption on the unreconstructed Ir(100)-(1 × 1) surface under ultra-high vacuum (UHV) conditions is studied with scanning tunneling microscopy (STM), low-energy electron diffraction (LEED), and high-resolution core-level spectroscopy (HRCLS). At a low coverage of 0.5 ML (monolayer), CO molecules adopt a previously documented c(2 × 2) structure, having CO
A novel approach combining 3D printing, phase inversion, and microwave plasma-enhanced chemical vapor deposition is presented. This technique enables the creation of carbon-based electrodes with precise micro- and nanoscale control, offering potential for sustainable and high-performance wastewater treatment applications. The synthesized 3D carbon scaffolds, enriched with B,N-doped carbon nanostru
Over the last century, district heating (DH) has only achieved global market shares of around 10 %. To reach its potential market shares of 25–50 % in Europe by 2050, growth must drastically accelerate. But deployment of DH is hindered by barriers, potentially slowing this fast-paced transition of the heat system. In this paper, we identify barriers to the deployment of DH through manual and GPT-a
