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Background: Plasma phosphorylated tau217 (p-tau217) is a robust biomarker of Alzheimer's disease (AD) pathology. However, its full potential as a dynamic marker has still not been verified in very old persons, i.e., those with the highest incidence of AD. Objective: To examine the cross-sectional and longitudinal associations between plasma p-tau217 concentration and cerebrospinal fluid (CSF) AD b
Suicide in children and young adults is a leading cause of premature mortality, and there is a need to develop a more profound understanding of the factors that contribute to these deaths. This study is part of the nationwide Retrospective Investigation of Health Care Utilization in Individuals who died by Suicide in Sweden 2015, conducted at Lund University, Sweden. The aim was to examine symptomSuicide in children and young adults is a leading cause of premature mortality, and there is a need to develop a more profound understanding of the factors that contribute to these deaths. This study is part of the nationwide Retrospective Investigation of Health Care Utilization in Individuals who died by Suicide in Sweden 2015, conducted at Lund University, Sweden. The aim was to examine symptom
Autoimmune diseases occur due to the abnormal response of the adaptive immune system towards the body's tissues, recognizing them as foreign and leading to chronic inflammation and harm to the tissues. Toxicologists and other scientists believe that factors such as genes, surroundings, and lifestyle can make autoimmune diseases more likely. Xenobiotics, such as chemical pollutants, drugs, microbes
Background: Having overweight is increasingly recognized as a risk factor for poor breast cancer (BC) outcomes. Previous studies have linked high body mass index (BMI) to an increased risk of recurrence and higher mortality. While most research has focused on patients treated with adjuvant chemotherapy, this study examines the impact of overweight on recurrence-free survival (RFS) in BC patients t
Background: Pain in childhood is common, but there is an information gap on initial care seeking. Our aim was to determine trends and variations in the consultation prevalence and incidence of musculoskeletal pain, and most common sites of pain, in children and young people presenting to UK primary care. Methods: A national UK primary care database (CPRD Aurum) was used to determine annual prevale
A survey on vaccinations was conducted among patients with chronic inflammatory diseases (CIDs), including inflammatory bowel disease, inflammatory rheumatological diseases, and dermatological diseases (DDs). The objective was to identify differences between established vaccination guidelines and actual practices in healthcare as experienced by patients. Among eligible responders (n = 1434), 57% w
Background Colorectal cancer (CRC) remains a major global health challenge with high morbidity and mortality despite advances in detection and treatment. Dietary polyphenols are secondary metabolites widely found in plant-derived foods and beverages, and have gained attention for their potential in CRC prevention and therapy due to their diverse biological activities. Methods This review synthesiz
Background: Japan lacks efficient assessment tools for occupational balance (OB) in people with mental illness (MI). Aims/objectives: We investigated the test–retest reliability and construct validity of a Japanese version of the Satisfaction with Daily Occupations and Occupational Balance (SDO-OB-J) for people with MI. Methods: SDO-OB-J interviews were conducted twice at a 2-week interval. Result
Our planet is inhabited by an estimated 2.5 million species of fungi, of which fewer than 10% have been scientifically described. Some of the most understudied yet remarkable fungal species are those capable of parasitizing arthropods, notably insects and spiders. Here, we explore the hidden diversity of a spider-attacking (araneopathogenic) fungus and its associated microbiome in one of the world
Offshore carbon capture and storage (CCS) deployment has been hailed as a game changer in the ever-changing climate game in the era of Paris Agreement. In the European Union (EU), rigorous regulation within a legal framework governs cross-border offshore CCS projects, while China adopts a flexible policy-oriented approach. This article employs a multi-method research approach, combining legal doct
Over the years, demand-responsive transport (DRT) and similar concepts have been implemented and tested in different environments and in different configurations. However, many of these transport services have been abandoned, for various reasons. Previous research shows that some of the most important success factors for a DRT service to sustain over the years are low-cost solutions adjusted to a
The Dirichlet–Neumann alternating method is a common domain decomposition method for nonoverlapping domain decompositions without cross-points, and the method has been studied extensively for linear elliptic equations. However, for nonlinear elliptic equations, there are only convergence results for some specific cases in one spatial dimension. The aim of this manuscript is therefore to prove that
The integrated sensing and communication (ISAC) technique has recently gained significant attention in both academic and industrial sectors, as it can provide both sensing and communication functions using the same transmission and frequency spectrum. In this paper, a geometrically based statistical ISAC channel model for vehicle-to-vehicle (V2V) scenario is established, based on the ray tracing s
Experience of abuse as a life event is common among men in a psychiatric care context. Systematically charting life events and abuse plays a central role within psychiatric and mental health nursing and could improve the understanding of the patient’s life situation. The aim of the study was to explore the life course of male psychiatric patients who had experienced domestic abuse as victims and a
Background: The accelerating global ageing phenomenon has given rise to a growing concern regarding cognitive decline in older adults. Research shows that spouse health is closely linked to individual well-being, as the physical and emotional health of one partner significantly affects the other. Although the connection between spousal health and older adults’ cognitive function has been recognize
Introduction: Assessing work capacity and determining appropriate sick leave is a complex process. Despite the importance of fair and consistent assessments, evidence suggests that evaluations may vary. However, previous studies have been inconclusive and have mainly focused on whether sick leave should be recommended or not. The present study examined the medical reliability and consistency of ph
In this paper, we show that the set of torsion elements of a topological group admitting a branch pro-p quotient has Haar measure zero.
Using newly digitised colonial medical time-series data, this study makes a first attempt to provide an overview of the development of Western healthcare in Northern Rhodesia. The data is used to elaborate on the extent of the Christian missionary medical outreach to the African populace and the involvement of the African medical workers in establishing and expanding the Western healthcare system
