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BackgroundMultigene expression assays for molecular subtypes and biomarkers can aid clinical management of early invasive breast cancer. Based on RNA-sequencing we aimed to develop single-sample predictor (SSP) models for conventional clinical markers, molecular intrinsic subtype and risk of recurrence (ROR).MethodsA uniformly accrued breast cancer cohort of 7743 patients with RNA-sequencing data

As retail is becoming increasingly digitised in its operation and consumer relationships, much faith is put into automation, prediction and insights drawn from consumer data to shape consumer experiences and expectations. Under the umbrella of data-collection and artificial intelligence (AI), this chapter studies the role of consumer trust in retail personalisation. We draw empirical insights from

We celebrate Govindjee, Professor Emeritus of Plant Biology, Biochemistry, and Biophysics, University of Illinois at Urbana-Champaign, on the occasion of his 90th birthday. He is renowned for his pioneering work in the discovery of the two-light reactions and two photosystems, PSI and PSII, leading to the Z-scheme of the electron transport chain; and for breakthrough advances in oxygenic photosynt

In the passive solar water heater, temperature stratification is a valuable thermodynamic parameter for horizontal water storage tanks. This investigation aims to optimize the deflector and numerically study the effects of various deflector lengths and materials on temperature stratification of a horizontal water storage tank during natural convection. Firstly, comparative thermal performances of

Background: Chronic or recurrent rhinosinusitis without polyps (CRSsNP) is characterized by a persistent inflammation of the sinonasal mucosa. The underlying cause is unclear but increasing interest has been directed toward changes in the sinonasal microbiome as a potential driver. Methods: Twenty-two patients diagnosed with CRSsNP were treated with antibiotics for 13 days, followed by 5 consecuti

Dyspnea is a common and highly distressing symptom in patients with advanced illnesses. Many patients continue to experience chronic dyspnea despite optimal management of underlying disease(s) and various non-pharmacologic interventions, necessitating the consideration of pharmacologic therapies for palliation of dyspnea. One commonly asked question by clinicians is whether benzodiazepines have a

Olfactory loss is a common non-motor symptom of Parkinson’s disease (PD), often preceding the cardinal motor symptoms of the disease. The aim of this thesis was to: (a) evaluate whether olfactory examination can increase diagnostic accuracy, and (b) study the structural and functional neural basis of olfactory dysfunction in PD with different applications of Magnetic Resonance Imaging (MRI).Paper

IntroductionThe development of neutralising (inhibitors) and non-neutralising antibodies (NNAs) is a complication to factor replacement therapy in haemophilia. The diagnostic methods available lack standardisation, have high inter-laboratory variation, and false-negative as well as false-positive results may affect treatment. Both functional inhibitors and NNAs may be detected with higher reproduc

Does media history really start with a bang? More than just newspapers, television, and social networks, media are the means by which any information is communicated, from cosmic radiation traces to medieval church bells to modern identity documents. Cultures are held together as much by bookkeeping and records as they are by stories and myths.From Big Bang to Big Data is a long history of the med

Functional overlap among species (redundancy) is considered important in shaping competitive and mutualistic interactions that determine how communities respond to environmental change. Most studies view functional redundancy as static, yet traits within species—which ultimately shape functional redundancy—can vary over seasonal or spatial gradients. We therefore have limited understanding of how

Purpose: The aim of this study was to explore how women experienced sexuality after radical cystectomy due to bladder cancer. Methods: We performed an interview study with qualitative design with content analysis. Inclusion criteria were age below 75 years. In total 10 women, with a median age of 64 years at surgery, were interviewed at median 24 months post radical cystectomy. Results: The 10 wom

Crises are a major driving force behind cooperation in the European Union. During severe crises, cooperation has been enlarged and intensified. The Ukrainian war and the covid-19 pandemic are two examples of this pattern, not least when it comes to the conduct of stabilization policies in the EU. In this chapter, we discuss the implications for the EU of a move towards increased fiscal federalism.

Governments exercise power over the public in many ways. One clear example is during societal crises when government agencies engage in purposeful strategic communication, issue restrictions and recommendations, and rely on people’s compliance to reach response objectives and meet needs in society. Here, issues of authority and legitimacy are crucial. In this study, we are interested in how this p