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Introduction: Long-term pelvic floor symptoms after childbirth may impair women's quality of life. The aim of this study was to assess the prevalence of self-reported pelvic floor symptoms 1 year postpartum in primiparous women by degree of perineal tear, with a focus on minor and major second-degree tears, and their association with quality of life. Material and Methods: This prospective cohort s

The unusually broad and intense visible (Vis) absorption band observed in naphthalenediimide–bithiophene (NDI-T2) co-polymers reflects complex electronic and vibronic interactions between donor and acceptor units. While the charge-transfer character arising from electronic coupling across the moieties likely contributes to the red-shifted absorption, the pronounced spectral broadness may also orig

Background: L-DOPA-induced dyskinesia is attributed to opposite activity changes mediated by D1 and D2 dopamine receptors in the two striatal output pathways. Whereas the causal role of direct-pathway D1 receptors is well established, the specific involvement of indirect-pathway D2 receptors in dopaminergic dyskinesias has remained elusive. Objectives: We used conditional knockout approaches in mi

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a multifactorial disorder involving gut-brain axis dysregulation, altered barrier integrity, microbial imbalance, and stress-related mechanisms, with limited nutritional strategies targeting these pathways. Tannin-rich extracts may exert barrier-protective, microbiota-modulating, and stress-related effects. In a prospective before-after pilo

Background: Treatment of brain injuries and neurodegenerative disorders is a critical challenge due to poor regenerative capabilities of the central nervous system. The current therapeutic strategies are primarily focussed on treating the symptoms than addressing the core issue of loss of neurons. Despite advances in stem cell therapies and surgical alternatives, they are not always successful due

Introduction: Prolonged intense physical activity, such as long-distance running, may lead to systemic inflammation and cause organ injury, particularly to the kidneys. This study aimed to assess the impact of trail race running on kidney and muscle injury and gut inflammation biomarkers, and the potential mitigating effects of Lactiplantibacillus plantarum 299v (Lp299v) supplementation. Methods:

Utvecklingen av de strukturella egenskaperna hos metaller är kritisk för en effektiv användning av naturtillgångar och en cirkulär ekonomi. På senaste tid har en ny klass material med imponerande strukturella egenskaper visats sig vara väldigt intressanta, nämligen harmoniskt strukturerade material. I den här rapporten analyseras en simulering av ett dragprov för att synliggöra de essentiella mekaThe improvement of the structural properties in crystalline materials is of critical importance for an efficient use of natural resources and a circular economy. It has been found that these properties can be altered through severe plastic deformation. Bimodal harmonic structured (bHS) materials is a new class of materials having specified topological arrangement of coarse- and ultra-fine grains.

I detta arbete undersöks möjligheten att införa ett webbaserat alternativ till den nuvarande Qt-baserade gränssnittsdelen i kursen VSMN20, Programutveckling för tekniska tillämpningar, vid Lunds Tekniska Högskola. Bakgrunden är en tydlig rörelse på programvarumarknaden mot webbaserade och molnbaserade lösningar, och frågan om hur man skulle kunna få in den förändringen i en kurs där studenter arbeThis study evaluates three Python-based frameworks for developing web applications for finite element analysis: Dash, Streamlit, and NiceGUI. The evaluation focused on interactivity, usability, and suitability for inclusion in a course at LTH about software development for technical applications. To compare the frameworks, the final course project was recreated in each of them while keeping the un

The International Bladder Cancer Group (IBCG) has proposed a prognostic model for intermediate risk (IR) non-muscle invasive bladder cancer (NMIBC) for clinical decision-making. We applied the IBCG IR model in a population-based Swedish setting in patients with primary IR NMIBC diagnosed 2013-2014 in BladderBaSe 2.0. Patients were stratified into low-risk (unifocal and tumour size < 3 cm) and inte

Fixed-target platforms provide convenient support for microcrystals during serial X-ray crystallography studies using synchrotron radiation. Here, we describe a simple user-friendly 3D-printed support where the crystals are sandwiched between two layers of thin X-ray-transparent membrane resulting in very low scattering background. The platform is compatible with magnetic mounting onto the standar

Rising global temperatures and compound climatic extremes outpace avian thermoregulatory capacity. Yet, heat tolerance has been studied in only 1–2% of birds, mostly from the southern subtropics. The field requires research in two main areas. First, temperature and humidity must be considered in unison, and we provide a guiding, biophysical, framework for how these factors interact across climates

Background/Objectives: Contemporary healthcare systems are characterised by rapid change, high workload, and staff shortages, creating conditions that may compromise care quality and generate turbulence in nursing. Turbulence has been discussed in nursing research. However, greater conceptual clarity is needed regarding its underlying factors and implications for nursing work. The aim of this stud

AIMS: To investigate the prevalence of diastolic dysfunction and associated risk factors in pre-diabetes and diabetes in the general population.METHODS: Diastolic function was assessed by transthoracic echocardiography in a cross-sectional sample of 3840 men and women aged 50-64 years from the Swedish CArdioPulmonary bioImage Study. Anthropometry, medical history, blood pressure, biochemistry and

Cells must recycle stalled ribosomes while preventing the accumulation of aberrant nascent chains. In bacteria, this is achieved by overlapping pathways with distinct substrates: ribosome-rescue systems act mainly on non-stop mRNAs, whereas ribosome-associated quality control (RQC) targets mid-ORF arrests. Work in Gram-positive bacteria defined an RQC mechanism that appends C-terminal degrons to s

Background & Aims Microscopic colitis (MC) is a leading cause of chronic diarrhea, particularly in older adults. Although many patients respond to budesonide, refractory and dependent cases pose major therapeutic challenges. Although the off-label use of advanced inflammatory bowel disease therapies is expanding, robust real-world data remain scarce. Methods Through the ECCO CONFER network, we

Our point of departure has been that, by using the language of solidarity, we - consciously or not - participate in the politics of it. The group of authors coming together in this volume contribute analyses of solidarity as a norm, a process, a practice, or a vocabulary creating polyperspectivity. In so doing, we let the course of our analysis be directed by the actors we investigate over a span

Waste sorting is a cognitively demanding task with high environmental stakes. To support research on the categorisation and decision processes underlying waste sorting behaviour, this paper introduces an evaluated stimulus set of 790 images of naturally occurring waste items. The images were sampled from Danish and Swedish household waste, visually standardised, and evaluated by 526 Swedish partic