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Purpose: To investigate whether the reduced retinal function and morphological retinal changes previously demonstrated in ABCA4 carriers had remained stationary or had deteriorated over time at 5-year follow-up to further explore if carriers of an autosomal recessive trait also express a weak phenotype, although this is not expected for an autosomal recessive disorder. Methods: Thirteen ABCA4 carr

Pulmonary hypertension (PH) is a risk factor for morbidity and mortality in patients undergoing surgery and anesthesia. This document represents the first international consensus statement for the perioperative management of patients with pulmonary hypertension and right heart failure. It includes recommendations for managing patients with PH being considered for surgery, including preoperative ri

Ultrafast electron dynamics in quantum cascade lasers hold enormous potential for the implementation of intense, compact mode-locked terahertz sources, squeezed terahertz light, frequency mixers, and comb-based metrology systems. Yet the important sub-cycle dynamics have been notoriously difficult to access in operational terahertz quantum cascade lasers. Here we show the first field-resolved two-

A large share of growth in the sharing or platform economy is driven by peer-to-peer (P2P) accommodation providers such as Airbnb. The literature argues for both positive and negative socio-cultural, economic and environmental impacts emanating from the tourism and hospitality businesses and value chains that are dependent on AirBnB and other online platforms. These impacts are felt in terms of co

In the context of the exponential growth of data, the Covid 19 pandemic and the need for quick adaptation faced by companies, as well as by society at large, the concept of organisational learning is flourishing and becoming an even more critical component of organisational survival and growth. This study applies a socio-technical lens to shed light on the organisational learning processes taking

Vaccinations are one of the most significant interventions to public health, but vaccine hesitancy creates concerns for a portion of the population in many countries, including Sweden. Since discussions on vaccine hesitancy are often taken on social networking sites, data from Swedish social media are used to study and quantify the sentiment among the discussants on the vaccination-or-not topic du

We report the discovery of a novel neo-sex chromosome in an African warbler, Sylvietta brachyura (northern crombec; Macrosphenidae). This species is part of the Sylvioidea superfamily, where four separate autosome–sex chromosome translocation events have previously been discovered via comparative genomics of 11 of the 22 families in this clade. Our discovery here resulted from analyses of genomic

With air-photonics THz platform, we investigated photo-induced carrier dynamics of single and multilayer 2D perovskite single crystals. Interesting novel features and physics are revealed with effective conductivity spectrum up to 12 THz and 40-fs time resolution.

Background purpose: A substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort. Materials and methods: Analyses relied upon imaging and clinical data from the international MRI-GENIE study. Imaging data comprised both Fluid-attenuated inversion recovery (FLAIR) for white

We consider a spectral problem associated with steady water waves of extreme form on the free surface of a rotational flow. It is proved that the spectrum of this problem contains arbitrary large negative eigenvalues and they are simple. Moreover, the asymptotics of such eigenvalues is obtained.

It has long been known that the story of Barlaam and Ioasaph - or Barlaam and Iosafat as it was known in the Latin West - despite being a Christian legend is really a Buddha life that has gone through several transformations. From a probably Sanskrit original, the story passed through a Manichaean version, was turned into an Ismaelitic Muslim legend; from there it passed into a Georgian Christian

Abstract in Danish:En nærmere undersøgelse af baggrunden for de reformer, som Manuel I Komnenos (1118-80) forsøgte at indføre mod slutningen af sin regeringstid, viser at disse forsøg udsprang af en tidligere knæsat holdning i Byzans over for Islam. Hvad Manuel ønskede at gøre var at bringe sin religionspolitik i tråd hermed og med den der blev ført i det konkurrerende emirat i Ikonium (Konya), me

Background: Gallbladder cancer (GBC) is an aggressive, uncommon malignancy, with variation in operative approaches adopted across centres and few large-scale studies to guide practice. We aimed to identify the extent of heterogeneity in GBC internationally to better inform the need for future multicentre studies. Methods: A 34-question online survey was disseminated to members of the European-Afri

Parkinsons sjukdom är en kronisk neurodegenerativ sjukdom karaktäriserad avtypiska motoriska symtom i form av långsamma rörelser, muskelstelhet ochvilotremor. Dessa symtom orsakas av en brist på signalsubstansen dopamin i deområden av hjärnan som kontrollerar rörelser (hjärnbarken, basala ganglierna ochthalamus). Parkinsonmedicin, varav det mest effektiva är levodopa, mildrarsymtomen genom att ökaParkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. Thiscompound exerts its motor effects by stimulating dopamine D1 and D2 receptors,whose expressio

Syftet med den här rapporten är att bidra till en ökad förståelse av handelns innovativa förmåga och att bidra till ett för handeln anpassat sätt att leda och organisera innovation. Tillsammans med de företag som har varit delaktiga i forskningsprojektet vill vi dela med oss av de utmaningar och lösningar som vi har identifierat, diskuterat och analyserat i relation till den existerande kunskapen

New approaches based on -omics technologies can identify biomarkers and processes regulated in response to xenobiotics, and thus support toxicological risk assessments. This is vital to meet the challenges associated with “cocktail effects”, i.e. combination effects of chemicals present simultaneously in a product, our environment, and/or our body. For plant protection products (PPPs), investigati

Background: Little is known about how PFAS concentrations in human milk change over the course of lactation, although this is an important determinant of cumulative infant exposure from breastfeeding.Objective: To estimate changes in PFAS concentrations in human milk over the course of lactation in a population with a wide range of exposure from background-to high-exposed.Methods: We measured PFAS