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Gastrointestinal stromal tumors (GISTs) are predominantly initiated by KIT mutations. In this study, we observed that discoidin domain receptors 1 and 2 (DDR1 and DDR2) exhibited high expression in GISTs, were associated with KIT, and enhanced the activation of both wild-type KIT and primary KIT mutants. Inhibition of DDR1/2 led to a reduction in the activation of KIT and its downstream signaling
Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient representatives, addresses the challenges of clinical axillary lymph node management, from diagnosis to l
This study investigates binomial consumer brand engagement (vs. advertising avoidance) in the social media context. Grounded in social exchange theory, the relationships between personalized advertising, information control, privacy concerns, advertising avoidance, and consumer brand engagement are analyzed by drawing on a survey comprising n = 429 participants. The findings reveal that personaliz
Photosensitizers for sensitized triplet-triplet annihilation upconversion (sTTA-UC) often rely on precious heavy metals, whereas coordination complexes based on abundant first-row transition metals are less common. This is mainly because long-lived triplet excited states are more difficult to obtain for 3d metals, particularly when the d-subshell is only partially filled. Here, we report the first
Tuberculosis (TB) is the most common cause of death among people with HIV (PWH). PWH often have atypical clinical manifestations of TB, and TB disease can therefore be missed. Better screening markers could identify individuals with high likelihood of TB disease. Furthermore, the mechanisms underlying the immunopathogenesis of TB disease in PWH remain incompletely understood.This thesis is based o
We experimentally observe longer than long trajectory influence in high-order harmonic generation (HHG) by varying the peak intensity of the driving laser field either through direct attenuation or by chirping the laser pulse. Using a theoretical Gaussian beam model to simulate spatial interference resulting from quantum path interference, we show that the measured interference patterns cannot be
The self avoiding walk (SAW) model of the polymer has been extended to study the equilibrium properties of double stranded DNA (dsDNA) where two strands of the dsDNA are modeled by two mutually attracting self-avoiding walks (MASAWs) in the presence of an attractive surface. We study simultaneous adsorption and force induced melting transitions and explore different phases of DNA. It is observed t
We present state-of-the-art high-precision theory predictions for the dominant angular coefficients parametrizing the spin-correlations in the production and decay of a W-boson produced at transverse momentum larger than 30 GeV. The computation at NNLO QCD and NLO EW accuracy are combined to obtain differential distributions in the W-boson transverse momentum and rapidity. The found results show u
Implementing solar photovoltaic systems in the built environment (BEPV) is critical for the construction sector’s contribution to mitigating climate change. While previous studies give various insights into innovation implementation, the challenges to value co-creation by construction actors remain underexplored. By studying the alignment of business ecosystems implementing BEPV in the Swedish bui
Abstract in GermanDas Thema dieses Beitrags ist die Übersetzung deutscher Partizipialkonstruktionen ins Schwedische – ein Thema, dem die bisherige Forschung kaum Aufmerksamkeit geschenkt hat. Die Studie ist sowohl quantitativer als auch qualitativer Natur. Als Korpus dienen deutsche Sachprosatexte und ihre schwedischen Übersetzungen, von denen anzunehmen ist, dass sie im Einklang mit den entsprech
Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be class
